Abstract:Objective To study the clinical effect of Lyophilized Recombinant Human Brain Natriuretic Peptide combined with Levosimendan in patients with acute heart failure.Methods Ninety-two patients with acute heart failure admitted to the First People's Hospital of Hechi City from April 2017 to April 2018 were selected as the data subjects.According to the random number table method,they were divided into study group(n=46)and control group(n=46).Patients in the control group were treated with Levosimendan alone,while those in the study group were treated with Lyophilized Recombinant Human Brain Natriuretic Peptide combined with Levosimendan.The clinical treatment efficiency of the two groups was compared.The changes of B-type natriuretic peptide level,serum uric acid level and cardiac function indexes (left ventricular ejection fraction [LVEF]and left ventricular end-diastolic diameter[LVEDD])before and after treatment in the two groups were compared.Results The total effective rate in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in B-type natriuretic peptide level,serum uric acid level,LVEF and LVEDD between the two groups(P>0.05).After treatment,the level of B-type natriuretic peptide and serum uric acid in the study group were significantly lower than those in the control group,and LVEF and LVEDD were significantly higher than those in the control group,with statistically significant differences(P<0.05).After treatment,the level of B-type natriuretic peptide and serum uric acid in the two groups were significantly lower than those before treatment,and LVEF and LVEDD were significantly higher than those before treatment,with statistically significant differences (P<0.05).Conclusion The application of Lyophilized Recombinant Human Brain Natriuretic Peptide combined with Levosimendan in the treatment of acute heart failure is beneficial to the improvement of clinical treatment.
杨理会. 冻干重组人脑利钠肽联合左西孟旦治疗急性心力衰竭的临床效果[J]. 中国当代医药, 2019, 26(3): 120-122.
YANG Li-hui. Clinical effect of Lyophilized Recombinant Human Brain Natriuretic Peptide combined with Levosimendan in the treatment of acute heart failure. 中国当代医药, 2019, 26(3): 120-122.