Abstract：Objective To explore the clinical value of B-type natriuretic peptide（BNP）and serum carbohydrate antigen 125（CA125）in the diagnosis of acute heart failure.Methods 60 patientswith acute heart failure in our hospital from January to December 2015 were selected.According to New York Heart Association（NYHA）classification，all patients were divided into cardiac functionⅡ，Ⅲ，Ⅳgroup.Another group of 20 participants for physical examinations during the same period was selected.The level of BNP and CA125 from each group was compared.Correlation analysis was based on the values of BNP and CA125 and echocardiographic parameters.The correlation between these indexes and adverse cardiovascular events including refractory heart failure，malignant arrhythmia，cardiogenic shock，and sudden cardiac death within three-month follow-up visits aswell as re-hospitalization due to acute heart failure were observed.Resu lts In comparison with the control group，the level of BNP and CA125 in these heart failure patientswere greatly improved and were gradually increased following NYHA classification elevating，with statistical differences（P＜0.01）.The level of BNP and CA125 have negative correlationswith left ventricular ejection fraction（LVEF），these two indexes have positive correlationswith left ventricular end diastolic diameter（LVEDD），which have positive correlations with pulmonary artery pressure.After analyzing the specificity and sensitivity of BNP and CA125 in predicting the prognosis of heart failure，CA125 could better predict the prognosis in comparison with that by BNP.Conclusion The levels of BNP and CA125 are increasing in acute heart failure.CA125 can be considered as an important index on diagnosing heart failure，which plays important significance on predicting prognosis.
龚初平. BNP与CA 125检测在急性心力衰竭诊断中的临床价值[J]. 中国当代医药, 2016, 23(21): 130-133.
GONGChu-ping. Clinical value of BNP and CA125 detections in the diagnosis of acute heart failure. 中国当代医药, 2016, 23(21): 130-133.
Sharma R，Coats AJ，Anker SD.The role of inflama matory mediators in chronic heartfailure：cytokines，intric oxide，and endothelirr-1［J］.Int JCardiol，2000，72（2）：175-186.
［4］
Kang PM，Izumo S.Apoptosis and heard failure a cirtical review of the literature［J］.Cire Res，2000，86（11）：1107-1113.
Valgimigli M，Curello S，Ceconi C，et al.Neurohormones，cytokinesand programmed cell death in heart failure：a new paradigm for the remodeling heart［J］.Cardiovasc Drugs Ther，2001，15（6）：529-537.
Chun H，Yang J，Mi S，et al.Tumor necrosis factor-alpha G-308A polymorphism and risk of coronary heart disease and myocardial infarction：a case-control study and meta-analysis［J］.JCardiovasc Dis R es，2012，3（2）：84-90.
［10］
Wang TJ，LarsonMG，Levy D，etal.Plasmanatriuretic peptide levels and the risk of cardiovascular events and death［J］.N Engl JMed，2004，350（7）：655-663.
［11］
Yilmaz MB，Nikotaou M，Cohen SoLal A.Tumour biomarkers in heartfailure：is there a role for CA125？［J］.Eur J Heart Fail，2011，13（6）：579-583
［12］
Vizzardi E，D′Aloia A，Cumis A，et al.Carbohydrate antigen 125：a new biomarker in heart failure［J］.Cardiol Rev，2013，21（1）：23-26，
［13］
Ordu S，Ozhan H，Aemdar R，et al.Carbohydrate antigen-125 and N-terminal pro-brain natriuretic peptide levels∶compared in heart-failure prognostication［J］.Tex Heart inst J，2012，39（1）：30-35.
［14］
Huang F，Chen J，Liu Y，et al.New mechanism of elevated CA125 in heart failure：the mechanical stress and inflammatory stimuli initiate CA125 synthesis［J］.Med Hypotheses，2012，79（3）：381-383.
［15］
］Nunez J，Nunez E，Sanchis J，et al.Antigen carbohydrate 125 and brain natriuretic peptide serialmeasurements for risk stratification following an episode of acute heart failure［J］.Int JCardiol，2012，159（1）：21-28.
［16］
Rong X，Yunke Z，Guoping L，et al.Clinical and prognostic value of elevated CA125 levels in patients with coronary heart disease［J］.Herz，2015，40（4）：690-694.
［17］
Hamdy NM.Relationship between pro-anti-inflammatory cytokines，T-cell activation and CA125 in obese patients with heart failure［J］.Med SciMonit，2011，17（3）：174-179.［18］刘迪丹，林丽明，郭谷生.N端脑钠肽前体在心力衰竭诊断价值中的研究［J］.当代医学，2010，16（32）：36-37.
京公网安备 11010502046607号