Clinical effect of high-load dose of Teicoplanin in the treatment of Methicillin resistant Staphylococcus aureus pneumonia
ZHANG Zhi-hui1 FENG Yu-shan2 LI Kong-zheng3
1. Department of Pharmacy, Yangjiang People′s Hospital of Guangdong Province, Yangjiang 529500, China;
2. Department of Infectious Diseases, Yangjiang People′s Hospital of Guangdong Province, Yangjiang 529500, China;
3. Department of Physiotherapy, Yangjiang People′s Hospital of Guangdong Province, Yangjiang 529500, China
Abstract：Objective To analyze the clinical effect of high-load dose of Teicoplanin in the treatment of Methicillin resistant Staphylococcus aureus (MRSA) pneumonia. Methods A total of 252 patients with pneumonia infected with MRSA in Yangjiang People′s Hospital from January 2017 to December 2018 were selected as research subjects, they were divided into a high-load dose group (n=126) and a low loading dose group (n=126) according to the random number table method. Patients in the high-load dose group received high-load Teicoplanin treatment, patients in the low-load dose group received low-load Teicoplanin treatment. The pulmonary inflammatory exudation lesion absorption, clinical treatment effect, bacterial clearance, body temperature (T) and inflammatory indexes before and after treatment were compared between the two groups. Results The absorption of pulmonary inflammatory exudation lesions in the highload dose group was better than that in the low-load dose group, the difference was statistically significant (P＜0.05).The total effective rate of treatment in the high-load dose group was 95.2%, which was higher than 79.4% in the lowload dose group, the difference was statistically significant (P＜0.05). The total bacterial clearance rate of the high-load dose group was 89.7%, which was higher than 64.3% of the low-load dose group, the difference was statistically significant (P＜0.05). The C-reactive protein (CRP) and white blood cell count (WBC) of the high-load dose group were lower than those of the low-load dose group, the differences were statistically significant (P＜0.05). Conclusion Treatment of MRSA-infected pneumonia with high-load dose Teicoplanin can improve the absorption, treatment effect, and bacterial clearance of inflammatory exudation lesions in the lungs, and reduce the inflammatory index of patients.
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