Abstract：Objective To investigate the effect of permissive hypercapnia on Propofol combined with Sufentanil combined intravenous anesthesia.Methods From March 2016 to March 2017,90 cases of general anesthesia were selected in our hospital as study objects,and the patients were randomly divided into the control group(45 cases)and the study group (45 cases)according to the order of admission time.During the period of anesthesia,the arterial carbon dioxide partial pressure(PaCO2)of the control group was between 35～40 mmHg,while the study group was PaCO2 between 50～65 mmHg.The application of Propofol in two groups was compared(the concentration of Propofol and abdominal exploration and the time of postoperative recovery)and the PaCO2 level of 1,2 h after operation.Results①In the study group,the concentration of the effector domain was (2.511±0.206)mg/L at skin incision,and the concentration of the effector domain was(2.146±0.282)mg/L at intraperitoneal exploration,were lower than those of the study group(3.223±0.188)mg/L and(2.883±0.211)mg/L respectively,and the difference was statistically significant(P＜0.05）.The recovery time in control group was(15.35±3.22)min,which was not significantly different from that in the study group(16.68+5.36)min(P＞0.05）.②The PaCO2 levels of 1,2 h in the study group were(57.45±5.33)mmHg and(59.39±5.66)mmHg respectively,which were significantly higher than those in the control group(35.24±4.32)mmHg and(37.56±5.68)mmHg,and the difference was statistically significant(P＜0.05）.Conclusion It is safe and feasible to adopt permissive hypercapnia in patients undergoing general anesthesia.
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