血清同型半胱氨酸水平和甲状腺功能检测在先兆流产和稽留流产中的应用

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摘要目的探讨血清同型半胱氨酸（Homocysteine，Hcy）水平和甲状腺功能检测在先兆流产和稽留流产中的应用。方法回顾性选取2017年3～12月我院诊断为先兆流产63例患者为先兆流产组和诊断为稽留流产76例患者为稽留流产组，同期正常进行妊娠产检妇女57例为对照组，均采用化学发光法进行甲状腺功能和采用酶循环法进行血清Hcy水平检测。结果先兆流产组和稽留流产组血清游离甲状腺素（FT4）水平均高于对照组（P＜0.001），但是血清游离三碘甲腺原氨酸（FT3）水平却均低于对照组（P＜0.05），促甲状腺激素（TSH）血清水平比较，差异无统计学意义（P=0.537）。先兆流产组和稽留流产组间FT3血清水平比较，差异有统计学意义（P<0.05），FT4血清水平和TSH血清水平比较，差异均无统计学意义（P>0.05）；进一步分析各组中TSH≥2.5 mIU/L和TSH≥4.0 mIU/L的发生率，差异均无统计学意义（P>0.05）；先兆流产组和稽留流产组血清Hcy水平均高于对照组（P＜0.001），进一步按不同年龄分组分析显示，在＜30岁患者和≥30岁患者中，各组Hcy水平比较，差异均有统计学意义（P＜0.05）。结论 Hcy血清水平和甲状腺功能与流产存在较为密切的关系，在流产的预测和诊断中有较好的临床价值。

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	刘平
	曾祥兴
	邹春辉
	陈贻继
	李登峰

关键词 ：同型半胱氨酸, 甲状腺功能, 先兆流产, 稽留流产, 流产

Abstract：Objective To explore the application of serum homocysteine(Hcy)level and thyroid function testing in threatened miscarriage and missed abortion.Methods A total of 63 patients diagnosed as threatened miscarriage(threatened miscarriage group)and 76 patients diagnosed as missed abortion (misses abortion group)in our hospital from March to December 2017 were retrospectively selected.During the same period,57 women with normal pregnancy test classified into control group.The thyroid function was tested using the chemiluminescence method and the serum Hcy was tested by enzymatic cycle.Results The serum levels of FT4in the threatened miscarriage group and the missed abortion group were higher than that in the control group (P<0.001),but the serum levels of FT3were lower than that in the control group(P<0.05).The serum levels of thyroid stimulating hormone(TSH)were not displayed statistical significance after comparison (P=0.537).The comparison between the threatened miscarriage group and the missed abortion group,only the serum level of FT3 was in significant difference (P<0.05),and for the rest two indicators,there was no significant difference (P＞0.05).Further analysis indicated the incidence of TSH≥2.5 mIU/L and TSH≥4.0 mIU/L were not in significant difference(P＞0.05).The serum Hcy levels in the threatened miscarriage group and the missed abortion group were higher than that in the control group (P<0.001).Further analysis by different ages showed that patients＜30 years old and≥30 years old,Hcy levels were statistically different(P<0.05).Conclusion Hcy serum levels and thyroid function are closely related with abortion,which have good clinical value in the prediction and diagnosis of abortion.

Key words： Homocysteine Thyroid function Threatened miscarriage Missed abortion Abortion

基金资助:广东省河源市社会发展科技计划项目（2016-54）

引用本文:

刘平;曾祥兴;邹春辉;陈贻继;李登峰. 血清同型半胱氨酸水平和甲状腺功能检测在先兆流产和稽留流产中的应用[J]. 中国当代医药, 2018, 25(21): 130-132转136.
LIU Ping;ZENG Xiang-xing;ZOU Chun-hui;CHEN Yi-ji;LI Deng-feng. Serum homocysteine levels and thyroid function testing in threatened miscarriage and missed abortion. 中国当代医药, 2018, 25(21): 130-132转136.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2018/V25/I21/130

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