阿立哌唑对利培酮所致儿童和青少年精神分裂症患者高催乳素血症的影响

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摘要目的探讨阿立哌唑对利培酮所致儿童和青少年精神分裂症患者高催乳素血症的疗效及安全性。方法收集本院2012年10月～2014年2月符合入组标准的儿童和青少年精神分裂症患者73例，将其分为研究组（37例）和对照组（36例）。两组沿用原有抗精神病药物，研究组加用阿立哌唑5 mg/d治疗，持续8周。分别于入组前、入组第4、8周末检测血清催乳素水平，同时采用阳性和阴性症状量表（PANSS）和治疗副反应量表（TESS）评定精神病性症状及药物不良反应。结果治疗第4、8周末，研究组血清催乳素水平较入组前及对照组显著降低（均P＜0.05）；对照组入组前后血清催乳素水平差异无统计学意义（均P＞0.05）。两组入组前后PANSS、TESS评分比较，差异无统计学意义（均P＞0.05）。结论小剂量阿立哌唑可有效降低利培酮所致儿童和青少年精神分裂症患者血清催乳素水平升高，且未增加药物不良反应。

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	涂亚婷
	陈海波
	梁锋

关键词 ：精神分裂症, 儿童和青少年, 阿立哌唑, 利培酮, 催乳素

Abstract：Objective To explore the effect of Aripiprazole in the treatment of hyperprolactinemia caused by Risperidone in children and adolescent schizophrenics.Methods 73 children and adolescents with schizophrenia in our hospital from October 2012 to February 2014 were divided into study group(n=37)and control group(n=36).Patients in control group continued to receive the previous therapeutic schemes,and patients in study group received Additional aripiprazole(5 mg/d)for 8 weeks.The serum prolactin(PBL)level was measured at baseline and at the end of 4thand 8thweek,and clinical symptoms and adverse reaction were assessed with the positive and negative syndrome scale(PANSS) and the treatment emergent symptom scale(TESS)at the same time.Results At the end of 4thand 8thweek,the levels of serum PRL in study group were significantly decreased than those of baseline and the levels of control group(all P＜0.05).The serum PRL level did not change during the study period in control group(all P＞0.05).Furthermore,no difference was found between the two groups in the scores of PANSS and TESS at each time point(all P＞0.05).Conclusion Aripiprazole can effectively downregulate the increased serum PRL caused by Risperidone in children and adolescent schizophrenic patients without affecting the adverse drug reaction.

Key words： Schizophrenia Children and adolescents Aripiprazole Risperidone Prolactin

引用本文:

涂亚婷；陈海波；梁锋. 阿立哌唑对利培酮所致儿童和青少年精神分裂症患者高催乳素血症的影响[J]. 中国当代医药, 2016, 23(30): 134-136.
TU Ya-ting；CHEN Hai-bo；LIANG Feng. The influence of Aripiprazole on hyperprolactinemia caused by Risperidone in children and adolescent patients with schizophrenia. 中国当代医药, 2016, 23(30): 134-136.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2016/V23/I30/134

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