Abstract：Objective To explore the application effect of premedication of Dexmedetomidine in hypertensive patients undergoing radical gastrectomy.Methods From May 2015 to May 2016,108 patients with hypertension treated by laparoscopic radical gastrectomy in our hospital were selected as study objects and they were randomly divided into control group and observation group,with 54 cases in each group.Patients in the observation group were given Dexmedetomidine (0.6 μg/kg)before the induction of anesthesia,and in the control group,the same volume of saline was provided.Heart rate(HR),mean arterial pressure(MAP)and oxyhemoglobin saturation(SpO2)were observed before anesthesia induction (T0),extubation(T1),5 minutes after extubation(T2),and 10 minitues after extubation(T3).The incidence rate of adverse reactions between two groups was compared.Results There was no significant difference between the two groups in T0period and the difference of SpO2from T1-T3was not significant(P＞0.05).At T1-T3,indexes of HR and MAP in the observation group were both lower than those in the control group (P＜0.05).The incidence rate of adverse reactions in the control group and observation group was 38.89%and 14.81%with a statistical difference(P＜0.05).Conclusion Premedication of Dexmedetomidine can reduce the restlessness and adverse reaction of general anesthesia during recovery period.
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