Effect of Scutellarin on angiokinesis responses in rats with spontaneous hypertension
CHEN Chen1 LI Qing-qing2 ZHANG Xiu-juan1 DU Xiao-hua1 DAI Ze-lan1 RAO Qiang1 DU Ting-yan1 YANG Wei-min1▲
1.School of Pharmacy,Kunming Medical University,Yunnan Key Laboratory of Natural Medicine and Pharmacology,Yunnan Province,Kunming 650500,China;
2.Department of Pharmacy,People′s Hospital of Chengjiang County in Yunan Province,Chengjiang 652599,China
Abstract：ObjectiveTo investigate the effect of Scutellarin (SCU)on angiokinesis responses in rats with spontaneous hypertension(SHR).MethodsIn this study,basilar artery(BA)and coronary artery(CA)vascular rings which were isolated for 14 weeks and 40 weeks respectively from SHR and its control of Wistar-Kyoto rats(WKY)were applied.Wire Myograph vascular tension analysis system was applied,and tension changes of BA and CA vascular rings were measured.The effects of SCU on hypertension induced cardiovascular and cerebrovascular angiokinesis in rats were observed.ResultsIn the vasodilator reaction assay,the angiokinesis effect of blood vessels was significantly enhanced by incubation with SCU(P＜0.001),and 40 weeks vasodilation was stronger than that 14 weeks.In vasocontraction response assay,the maximum contraction rate of blood vessels was decreased with the increase of SCU incubation concentration,and the EC50value in the SCU group was significantly higher than that in the control group(P＜0.05).ConclusionScutellarin has certain influence on the vasodilatation and vasocontraction responses induced by hypertension in rats.
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