Sodium Valproate as a mood stabilizer is widely used in patients with bipolar disorder, which is also effective for rapid cycling and mixed episodes about bipolar disorder.The damage of Sodium Valproate to liver function cannot be ignored.The use of Sodium Valproate in patients with POLG gene mutation will aggravate the damage of liver function, and even cause liver failure, leading to death of the patients.This article reports a case in which POLG gene mutation was detected during the early use of Sodium Valproate in the treatment of bipolar disorder and Sodium Valproate was discontinued in time.And through this case, it is recommended that psychiatrists should perform POLG gene analysis before treatment with Sodium Valproate, especially in patients suspected with mitochondrial disease.
刘 超； 易正辉；吕钦谕；王培涓. 双相情感障碍丙戊酸钠治疗过程中POLG基因突变1例分析[J]. 中国当代医药, 2020, 27(20): 193-196.
LIU Chao1,2 YI Zheng-hui2 LYU Qin-yu2 WANG Pei-juan1▲. Analysis of a case of POLG gene mutation during the treatment of bipolar disorder with Sodium Valproate. 中国当代医药, 2020, 27(20): 193-196.
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