Abstract：Objective To explore the expression level and clinical significance of exhaled nitric oxide (FeNO) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A total of 60 patients with AECOPD who were admitted to Meizhou People′s Hospital from October 2017 to September 2019 were selected as the study group.A tatal of 60 healthy volunteers who underwent physical examination in Meizhou People′s Hospital at the same period were selected as the control group.The FeNO,peripheral serum total immunoglobulin E (IgE),procalcitonin (PCT),C-reactive protein (CRP) and peripheral blood eosinophil levels in the two groups were measured.The levels of FeNO,IgE,PCT,CRP and peripheral blood eosinophil were compared between the two groups.Results The levels of FeNO and IgE in the study group were lower than those in the control group,while the PCT,CRP and peripheral blood eosinophil levels in the study group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion The production and release of nitric oxide increases in patients with acute exacerbation of chronic obstructive pulmonary disease.The increase of FeNO level indicates the presence of airway inflammation.The determination of FeNO level can predict the anti-inflammatory effect.
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