Abstract：Objective To investigate the clinical significance of serum 25-hydroxyvitamin D3 (25-[OH]D3) level determination in bronchiolitis.Methods All of 106 children with bronchiolitis admitted to Yingde Maternal and Child Health Family Planning Service Center from October 2017 to January 2018 were divided into mild group and severe group according to the diagnostic criteria of bronchiolitis, 53 cases in each group selected as the experimental group,while 106 healthy children in the same period in outpatient clinic were selected as the control group.Serum 25-(OH)D3 level of the three groups was detected respectively.Results The serum level of 25-(OH)D3 in severe group was lower than that of normal infants in mild group and control group (P<0.05).The serum level of 25-(OH)D3 in mild group was lower than that of normal infants in control group, and the differences were statistically significant (P<0.05).The insufficiency rate of serum 25-(OH)D3 level in severe group was higher than that in mild group and control group, and the insufficiency rate of serum 25-(OH)D3 level in mild group was higher than that in control group, and and the differences were statistically significant (P<0.05).The positive rate of viral detection in children with serum 25-(OH)D3 level<75 nmol/L in severe group was much higher than that in children with serum 25-(OH)D3 level<75 nmol/L in mild group, and the difference was statistically significant (P<0.05).Conclusion The incidence of bronchiolitis may be related to vitamin D deficiency, but excessive vitamin D can aggravate inflammation.Therefore, vitamin D supplementation in infants and young children should be paid attention during pregnancy, lactation and clinical work, but the way of administration and dosage of vitamin D should be further studied.
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