摘要目的 研究卡前列甲酯栓预防产后出血及改善子宫复旧的效果。方法 选取南京中医药大学沭阳附属医院2016年5月—2018年12月收治的130 例初产妇，采用随机数字表法分为两组，每组各65 例。对照组给予缩宫素治疗，观察组加用卡前列甲酯栓治疗，分析两组产后的临床疗效。结果 观察组的产后10、30、60 min 宫缩强度为（8.20±1.52）、（12.75±1.96）、（37.18±5.66）kPa，高于对照组的（5.98±1.46）、（10.13±2.11）、（29.22±5.41）kPa（P<0.05）；观察组的产后2 h 的出血量为（135.85±24.52）mL，产后24 h 出血量为（251.03±47.55）mL，血红蛋白（Hb）下降量为（5.16±2.55）g/L，红细胞比容（HCT）下降量为（2.96±1.14）%，产后出血率（0%），低于对照组的（218.23±31.63）mL、（411.02±59.68）mL、（15.44±3.96）g/L、（7.45±1.87）%、（6.15%）（P<0.05）；观察组的产后42 d 子宫体大小为（17.25±2.11）cm3，小于对照组的（23.52±3.05）cm3（P<0.05）；观察组的恶露持续时间为（20.86±8.41）d，短于对照组的（27.14±12.02）d（P<0.05）；观察组的产后42 d 宫底高度为（0.35±0.13）cm 与对照组的（0.38±0.11）cm 比较，差异无统计学意义（P＞0.05）。结论 卡前列甲酯栓可有效预防产后出血，加强产后宫缩强度，降低产后出血率，促进子宫复旧。
Abstract：Objective To study the effect of Carboprost Suppositories on preventing postpartum hemorrhage and improving uterine involution.Methods A total of 130 primiparae who were treated in the Shuyang Hospital Affiliated to Nanjing University of Chinese Medicine from May 2016 to December 2018 were selected and divided into two groups according to random number table method,65 cases in each group.In the control group,primiparae were treated with Oxytocin,and in the observation group,they were added with Carboprost Suppositories.These primiparous clinical effects of the two groups were analyzed.Results The intensity of uterine contractions at 10,30 and 60 min in the observation group were(8.20±1.52),（12.75±1.96）and(37.18±5.66)kPa,which were all stronger than those of control group of(5.98±1.46),(10.13±2.11),and(29.22±5.41)kPa(P<0.05).In the observation group,the amount of bleeding at 2 and 24 h after delivery were(135.85±24.52)and(251.03±47.55)mL,hemoglobin(Hb)decrease was(5.16±2.55)g/L,the hematocrit value(HCT)decrease was(2.96±1.14)%,and the postpartum hemorrhage rate was 0%,which were lower than those of the control group of(218.23±31.63)mL,(411.02±59.68)mL,(15.44±3.96)g/L,(7.45±1.87)%,and 6.15%,respectively(P<0.05).The uterine size at 42 d after delivery in the observation was(17.25±2.11)cm3,lower than that of the control group of(23.52±3.05)cm3,the duration in the observation of lochia was(20.86±8.41)d,shorter than that of the control group of(27.14±12.02)d(P<0.05).There was no statistical significance on height of uterine fundus at 42 d after delivery between the observation group of(0.35±0.13)cm and the control group of(0.38±0.11)cm,the difference had no statistical significance(P＞0.05).Conclusion Carboprost Suppositories can effectively prevent postpartum hemorrhage,strengthen the intensity of uterine contractions,reduce the rate of postoperative bleeding,promote uterine involution.
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