Abstract：Objective To investigate the changes of serum prostate-specific antigen(PSA)in patients with benign prostatic hyperplasia(BPH)after anterior lobe preserved transurethral plasmakinetic enucleation of prostate.Methods The clinical data of 85 patients with BPH who received anterior lobe preserved transurethral plasmakinetic enucleation in Nanhai Hospital of Southern Medical University from July 2017 to October 2020 were retrospectively analyzed.According to the size of prostate,they were divided into three groups:small group(<40 mL)20 cases,medium group(40-80 mL)49 cases and large group(>80 mL)16 cases.The serum PSA levels of patients in the three groups were compared before surgery,1,7 days after surgery,1,2 and 3 months after surgery.Results The PSA level of 85 patients on the first day after operation was higher than that before operation,with statistical significance(P<0.05).The PSA levels of the 1,7 day and 1 month after operation were compared with those of the previous time point,and the differences were statistically significant(P<0.05).There were no significant differences in PSA levels between 1,2 and 3 months after operation(P>0.05).The PSA levels before and 1 day after surgery were compared between three groups,and the differences were statistically significant(P<0.05).There were no significant differences in PSA levels between 7 days after surgery and 1,2 and 3 months after surgery(P>0.05).One month after surgery,the 95% value of PSA was 1.46 ng/mL.Conclusion There was no difference in the PSA levels of different volumes of prostate at one month after anterior lobe preserved transurethral plasmakinetic enucleation of prostate,and the PSA levels reached a stable level.The "baseline value" of PSA at one month after surgery was 1.46 ng/mL,which is helpful for the evaluation of the complete degree of BPH resection and the early detection of postoperative new prostate cancer.However,the "baseline value" may vary among patients with different BPH,and further study is needed.
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