Abstract：Objective To explore the application of high flux hemodialysis combined with hemoperfusion in the treatment of uremia. Methods A total of 80 patients with uremia admitted to the Department of Nephrology, the Third Hospital of Nanchang from April 2020 to July 2020 were selected as the research objects and divided into the control group (40 cases) and the observation group (40 cases) according to the random sampling. The control group was given high flux hemodialysis treatment, and the observation group was given hemoperfusion treatment on the basis of the control group, patients of both groups were treated continuously for 12 weeks. The changes of toxin clearance index, inflammatory factors and immune function before treatment and 12 weeks after treatment were compared between the two groups. Results After 12 weeks of treatment, the serum creatinine (Scr), blood urea nitrogen (BUN), parathyroid hormone(Pth), β2-microglobulin (β2-MG) and serum C-reactive protein ( CRP), serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) levels were lower than those before treatment in this group, and the observation group was lower than the control group; while serum immunoglobulin A (IgA) and immunoglobulin G ( IgG), immunoglobulin M (IgM) levels and complement C3, C4 levels were higher than those before treatment in this group, and the observation group was higher than the control group, the differences were statistically significant (P＜0.05). Conclusion High-flux hemodialysis combined with hemoperfusion can effectively remove various toxins in uremic patients, thereby reducing inflammatory factors, improving the immunity of uremic patients, and promoting the improvement of their condition.
阮春芸；刘圣山. 高通量血液透析联合血液灌流在尿毒症治疗中的应用研究[J]. 中国当代医药, 2021, 28(19): 130-133.
RUAN Chun-yun LIU Sheng-shan. Application study of high flux hemodialysis combined with hemoperfusion in the treatment of uremia. 中国当代医药, 2021, 28(19): 130-133.
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