中西医结合治疗糖尿病足感染的效果及对血清炎症因子的影响

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摘要目的探讨中西医结合治疗糖尿病足感染的效果及对血清炎症因子的影响。方法选取2018年2月～2020年3月南昌市洪都中医院收治的178 例糖尿病足感染患者作为研究对象，采用随机数字表法将其分为对照组（n=89）和观察组（n=89）。对照组患者给予西医治疗，观察组患者采用中西医结合治疗，经过1 个月治疗后对患者的治疗效果进行评估。比较两组患者的术后恢复时间、治疗前后中医证候量表评分、足背动脉管径、血流速度、血管细胞黏附分子-1（VCAM-1）、白细胞介素6（IL-6）、肿瘤坏死因子-α（TNF-α）以及C 反应蛋白（CRP）水平。结果观察组患者治疗后的病灶生长肉芽组织时间、足溃疡清创时间以及形成上皮组织时间均快于对照组，差异有统计学意义（P<0.05）。两组患者治疗前的中医证候量表评分、足背动脉管径以及血流速度比较，差异均无统计学意义（P>0.05）；治疗后，两组患者的中医证候量表评分以及血流速度均较治疗前降低，足背动脉管径均较治疗前上升，差异有统计学意义（P<0.05）；治疗后，观察组患者的中医证候量表评分以及血流速度均低于对照组，足背动脉管径高于对照组，差异有统计学意义（P<0.05）。治疗前，两组患者的血清炎症因子水平比较，差异无统计学意义（P>0.05）；治疗后两组患者的血清VCAM-1、IL-6、TNF-α、CRP 水平均较治疗前下降，差异有统计学意义（P<0.01）；观察组患者治疗后的各项血清炎症因子水平均低于对照组，差异有统计学意义（P<0.01）。结论中西医结合治疗在糖尿病足感染中的效果较好，可以促进患者患肢康复，缓解患者症状，改善足背动脉管径，加快血液流速，显著降低患者炎症因子水平，从而促使炎症恢复，对糖尿病足感染的治疗具有重要意义，值得推广应用。

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	李卫
	杨彩云

关键词 ：中西医结合治疗, 糖尿病足, 感染, 血清炎症因子

Abstract：Objective To explore the effect of integrated traditional Chinese and Western medicine in the treatment of diabetic foot infection and its influence on serum inflammatory factors. Methods A total of 178 patients with diabetic foot infection admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine from February 2018 to March 2020 were selected as the research subjects,and they were divided into the control group(n=89)and the observation group(n=89) by the random number table method. The control group was treated with Western medicine, and the observation group was treated with integrated traditional Chinese and Western medicine. After 1 month of treatment, the treatment effect of patients was evaluated. The postoperative recovery time, traditional Chinese medicine syndrome scale score,dorsal foot artery diameter, blood flow velocity, vascular cell adhesion molecule 1 (VCAM-1), interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) levels before and after treatment were compared between the two groups. Results After treatment, the time of granulation tissue growth, foot ulcer debridement and epithelial tissue formation in the observation group were faster than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in the score of traditional Chinese medicine syndrome scale,dorsal foot artery diameter and blood flow velocity between the two groups before treatment (P>0.05). After treatment,the scores of traditional Chinese medicine syndrome scale and blood flow velocity of the two groups were lower than those before treatment, and the dorsal foot artery diameter was increased compared with that before treatment, the differences were statistically significant (P<0.05). After treatment, the score of traditional Chinese medicine syndrome scale and the blood flow velocity of the observation group were lower than those of the control group, and the diameter of the dorsal foot artery was higher than that of the control group, the differences were statistically significant (P<0.05).Before treatment, there were no significant differences in serum inflammatory factor levels between the two groups (P>0.05). The levels of serum inflammatory factors in the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P<0.01). The levels of serum inflammatory factors in the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.01). Conclusion The combination of traditional Chinese and Western medicine is effective in treating diabetic foot infection. It can promote the rehabilitation of the patients′ limbs, relieve the symptoms, improve the diameter of the dorsal artery of the foot, speed up blood flow, and significantly reduce the level of inflammatory factors in the patients,thereby promoting the recovery of inflammation. It is of great significance to the treatment of diabetic foot infection, and it is worthy of promotion and applicatio

Key words： Integrated traditional Chinese and Western medicine treatment Diabetic foot Infection Serum inflammatory factors

引用本文:

李卫；杨彩云. 中西医结合治疗糖尿病足感染的效果及对血清炎症因子的影响[J]. 中国当代医药, 2021, 28(3): 189-192.
LI Wei ；YANG Cai-yun. Effect of integrated traditional Chinese and Western medicine in the treatment of diabetic foot infection and its influence on serum inflammatory factors. 中国当代医药, 2021, 28(3): 189-192.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I3/189

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