Clinical effect of intratracheal instillation of Bovine Pulmonary Surfactant for Injection combined with Budesonide in the treatment of neonatal respiratory distress syndrome
LIU Pan-li1 LUO Hong-bin1 LIAO Zhi-wei1 HU Min2▲ YANG Rui-fen1 LIU Wei-yun1 HU Yu1 XIAO Xiao-xing1
1. Department of Neonatology, Xinyu People′s Hospital, Jiangxi Province, Xinyu 338025, China;
2. Emergency Rescue Center of Xinyu City, Jiangxi Province 338025, China
Abstract：Objective To study the clinical effect of intratracheal instillation of Bovine Pulmonary Surfactant for Injection combined with Budesonide in the treatment of neonatal respiratory distress syndrome (NRDS). Methods Sixty children with NRDS admitted to the Department of Neonatology of Xinyu People′s Hospital from May 2017 to May 2019 were selected as subjects. They were divided into control group (n=30) and observation group (n=30) by lottery. The control group was treated with Bovine Pulmonary Surfactant for Injection, while the observation group was treated with intratracheal instillation of Bovine Pulmonary Surfactant for Injection combined with Budesonide. The blood gas analysis, clinical manifestations, oxygen saturation (SpO2), heart rate, invasive mechanical ventilation rate, mechanical ventilation time, hospital stay, biparietal diameter (BPD) incidence and total complication rate were observed. Results After treatment, arterial oxygen partial pressure (PaO2) and pH value of the observation group were higher than those of the control group, and mechanical blood carbon dioxide partial pressure ( PaCO2) was lower than that of the control group,the differences were statistically significant (P＜0.05). The scores of clinical manifestations including polypnea, groan,three concave signs, and complexion in the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). The SpO2 in the observation group was higher than that in the control group, and the heart rate was lower than that in the control group, the differences were statistically significant (P＜0.05).In the observation group, the invasive mechanical ventilation rate was lower, the mechanical ventilation time and hospital stay were shorter, and the incidence of BPD and the total incidence of complications were lower compared with those in the control group, the differences were statistically significant (P＜0.05). Conclusion Intratracheal instillation of Bovine Pulmonary Surfactant for Injection combined with Budesonide for children with NRDS can effectively improve blood gas analysis and clinical symptoms, reduce the invasive mechanical ventilation rate, the incidence of BPD and complications, and shorten mechanical ventilation time and hospital stay, which is worthy of promotion.
刘盼丽; 罗宏斌; 廖志伟; 胡敏; 杨瑞芬; 刘卫云; 胡渝; 肖小星. 注射用牛肺表面活性剂联合布地奈德气管内滴入治疗新生儿呼吸窘迫综合征的临床效果[J]. 中国当代医药, 2020, 27(7): 121-124.
LIU Pan-li; LUO Hong-bin; LIAO Zhi-wei; HU Min; YANG Rui-fen; LIU Wei-yun; HU Yu; XIAO Xiao-xing. Clinical effect of intratracheal instillation of Bovine Pulmonary Surfactant for Injection combined with Budesonide in the treatment of neonatal respiratory distress syndrome. 中国当代医药, 2020, 27(7): 121-124.
Li C，Zha O GF，He QY，et al.Study on the clinical efficacy of Human Urinary Kalllikrein in the treatment of acute cerebral infarction according to TOAST classification[J].Pak J Pharm Sci，2015，28（4 Suppl）：1505-1510.
[10]
El-Tatawy H，Gameel T，El-enen MA，et al.Clinical significance of prostatic-urethral angulation on the treatment outcome of patients with symptomatic benign prostatic hyperplasia treated with tamsulosin hydrochloride[J].Arch Ital Urol Androl，2015，87（3）：238-242.
[11]
Schjerning Olsen AM，Fosb l EL，Pallisgaard J，et al.NSAIDs are associated with increased risk of atrial fibrillation in patients with prior myocardial infarction：a nationwide study[J].Eur Heart J Cardiovasc Pharmacother，2015，1（2）：107-114.
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