Effect of emergency mechanical thrombectomy in the treatment of acute moderate to severe cerebral infarction after failure of intravenous infusion of Alteplase
HU Lie-ji
Two areas of Brain，Qingyuan People′s Hospital，Guangdong Province，Qingyuan 511500，China
Abstract：Objective To investigate the effect of emergency mechanical thrombectomy in the treatment of acute moderate to severe cerebral infarction after failure of intravenous infusion of Alteplase.Methods Sixty patients with acute moderate to severe cerebral infarction admitted to our hospital from February 2016 to February 2018 were enrolled in the study.They were divided into control group （n=30）and observation group （n=30）according to random number table method.In the control group，after the treatment of intravenous Alteplase thrombolytic therapy，the blood vessels were not recanalized.After 24 hours，the secondary cerebral hemorrhage was excluded by CT examination，and symptomatic treatment such as lipid-lowering and anti-thrombosis was continued.In the observation group，after failure of intravenous Alteplase thrombolytic therapy，emergency mechanical thrombectomy was performed.After 24 hours，secondary cerebral hemorrhage was excluded by CT examination，and symptomatic treatment such as lipid-lowering and antithrombosis was continued.The Barthel index，national institutes of health stroke scale （NIHSS）score，and post-treatment complications before and after treatment at 14 d and 28 d were compared in the two groups.Results Before treatment，there were no significant difference in Barthel index and NIHSS score between the two groups （P＞0.05）.The Barthel index of the observation group was higher than that of the control group after treatment，and the NIHSS score was lower than the control group at 14 d and 28 d with statistical significance （P＜0.05）.The incidence of complications in the two groups did not display statistically significant（P＞0.05）.Conclusion Emergency mechanical thrombectomy in the treatment of acute moderate to severe cerebral infarction after failure of intravenous Alteplase thrombolysis can obtain a favorable effect and is worthy of extensive promotion in clinical practice.
胡列计. 急诊机械取栓治疗阿替普酶静脉溶栓无效急性中重度脑梗死的效果[J]. 中国当代医药, 2019, 26(4): 83-85转88.
HU Lie-ji. Effect of emergency mechanical thrombectomy in the treatment of acute moderate to severe cerebral infarction after failure of intravenous infusion of Alteplase. 中国当代医药, 2019, 26(4): 83-85转88.
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