Abstract：Objective To investigate the clinical efficacy of early skull repair on patients with skull defect after traumatic brain injury.Methods A total of 50 patients with skull defects after craniotomy were enrolled in our hospital from September 2015 to September 2017.The patients were divided into the early group and the regular group by a random number table method，with 25 cases in each group.In the regular group，the skull repair was performed 3-6 months after decompressive craniectomy，while in the early group，decompressive craniectomy was performed from 40 days to 3 months.The Glasgow outcome scale （GOS）scores were compared between the two groups at 3 months after surgery.The improvement of neurological deficits and postoperative complications were observed in the two groups.Results The total effectiveness rate in the early group was 88.00%，which was higher than that 76.00%in the regular group，with statistical difference （P＜0.05）.There was no significant difference in the preoperative neurological deficit degree expressing as China stroke scale （CSS）score between the two groups （P＞0.05）.The CSS scores of the two groups decreased after surgery （P＜0.05），and the CSS score of the early group was lower than that of the regular group，with significant difference （P＜0.05）.There was no significant difference in the total incidence of postoperative complications between the two groups （P＞0.05）.Conclusion Skull repair in patients with skull injury after brain trauma can improve the recovery of neurological deficits in patients and the prognosis in good safety，which is worthy of further clinical research.
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