Abstract：ObjectiveTo investigate the clinical effect of new oral anticoagulant(Dabigatran)combined with Aspirin in the treatment of nonvalvular atrial fibrillation.Methods One hundred and fifty cases of nonvalvular atrial fibrillation treated in our hospital from February 2014 to August 2016 were selected as the subjects.According to the random number table method,they were divided into control group,research group 1 and research group 2,50 cases in each group.The controlgroupwastreated with Warfarin,and the research group 1 was treated with Dabigatran,and the research group 2 was treated with Aspirin Tablets combined with Dabigatran.The changes of coagulation index and cerebral hemorrhage,upper gastrointestinal bleeding,transient ischemic attack,pulmonary embolism,cerebral embolism and death were compared in the three groups before and after treatment.Results Before treatment,there was no significant difference in coagulation index between the three groups(P＞0.05).After treatment,the coagulation indexes in the three groups were significantly higher than those before treatment,and the differences were statistically significant(P＜0.05),while there was no significant difference in coagulation index in the three groups after treament(P＞0.05).No pulmonary embolism and death were found in all three groups.The incidence of transient ischemic attack,cerebral embolism,cerebral hemorrhage and upper gastrointestinal bleeding of research group 1 and research group 2 were both lower than those in the control group,and the differences were statistically significant(P＜0.05).The incidence of hemorrhage and upper gastrointestinal bleeding of research group 1 were lower than those in the research group 2,and the differences were statistically significant(P＜0.05).Conclusion In the treatment of nonvalvular atrial fibrillation,Dabigatran combined with Aspirin Tablets has no significant improvement in efficacy compared with Dabigatran alone,but increases the risk of bleeding.Compared with warfarin alone,combination therapy can reduce the incidence of transient ischemic attack,cerebral embolism and other events.
黄汉辉； 黄凯. 新型口服抗凝药联合阿司匹林治疗非瓣膜性房颤的临床分析[J]. 中国当代医药, 2018, 25(7): 51-53.
HUANG Han-hui；HUANG Kai. Clinical analysis of a new oral anticoagulant drug combined with Aspirin in the treatment of nonvalvular atrial fibrillation. 中国当代医药, 2018, 25(7): 51-53.
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