Abstract：ObjectiveTo analyze and compare the therapeutic effect of anticoagulant and double antithrombotic therapy in patients with coronary heart disease (CHD)and atrial fibrillation (AF).Methods A total of 100 patients with CHD and AF treated in our hospital from January 2015 to August 2016 were selected as subjects.The patients were divided into research group(n=50)and control group(n=50)according to the double-blind method.In the control group,double antithrombotic therapy was used,while in the research group,anticoagulation was adopted.The situation of follow-up visits,utilization rate of proton pump inhibitor(PPI)and scores of HAS-BLED and CHADS2 were comparatively analyzed.Results There was no significant difference between the two groups in secondary end point events and bleeding events(P＞0.05).The main end point event in the research group was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).The PPI utilization rate in the study group (14.00%)was significantly lower than that in the control group (42.00%),and the difference was statistically significant(χ2=9.722,P=0.001).The CHADS2 score of the two groups was not statistically significant(P＞0.05),and the patients in the research group had a statistically significant difference compared with the control group(P＜0.05).Conclusion For patients with CHD and AF,the anticoagulant effect is better than that of double antithrombotic therapy.The former improves therapeutic effect and reduces the risk of hemorrhage simultaneously,and has a high application value in clinical practice.
崔跃. 抗凝与双联抗栓治疗冠心病合并心房颤动的效果比较[J]. 中国当代医药, 2018, 25(7): 54-56.
CUI Yue. Effect comparison of anticoagulation and double antithrombotic therapy in the analysis of coronary heart disease with atrial fibrillation. 中国当代医药, 2018, 25(7): 54-56.
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