Abstract：Objective To investigate the changes of serum glial fibrillary acidic protein (GFAP)in cerebrospinal fluid(CSF)after severe craniocerebral injury and its correlation with intracranial pressure,so as to provide a basis for improving the diagnosis and treatment of severe craniocerebral injury.Methods A total of 42 cases of severe craniocerebral injury treated in our hospital from October 2016 to August 2017 were selected as the experimental group,and 42 cases of healthy physical examination or volunteers were selected as the control group.The cerebrospinal fluid samples were extracted from 6,12,24,48 and 72 h after injury,and the level of GFAP protein was detected,and the changes of intracranial pressure were monitored continuously,and the level of GFAP protein and intracranial pressure were compared with that of the intracranial pressure.At the same time,the correlation between the change of GFAP protein and the intracranial pressure at each time point after injury in the study group were analyzed.Results①The level of GFAP protein in cerebrospinal fluid in the experimental group was significantly higher than that of the control group(P<0.05）,and the 24 h reached the peak value in the experimental group after brain injury and decreased with the time.②The intracranial pressure increased immediately after injury in the experimental group,and the intracranial pressure at all time points was significantly higher than that of the control group(P<0.05）.The peak of intracranial pressure in the experimental group occurred at 48 h after injury,and the intracranial pressure remained at a high level after 48 h.③The intracranial pressure and cerebrospinal fluid GFAP protein in the experimental group showed an upward trend and a positive correlation (r=6.483,P<0.05）.ConclusionAfter severe craniocerebral injury,GFAP protein and intracranial pressure in cerebrospinal fluid are elevated,and their changes in early stage are consistent.The detection of GFAP protein and intracranial pressure in cerebrospinal fluid can be used for clinical diagnosis,to grasp the evolution of the disease and to provide reference for the treatment.
涂杳然;牛凡;洪德全. 重型颅脑损伤后脑脊液内GFAP蛋白的变化及其与颅内压的相关性研究[J]. 中国当代医药, 2018, 25(28): 39-41.
TU Yao-ran;NIU Fan;HONG De-quan. Changes of GFAP protein in cerebrospinal fluid after severe craniocerebral injury and its correlation with intracranial pressure. 中国当代医药, 2018, 25(28): 39-41.
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