Abstract：Diabetes in pregnancy including pre-gestational diabetes mellitus(PGDM)and gestational diabetes mellitus(GDM)is an important disease which can lead to many adverse pregnancy outcomes.In recent years,the prevalence rate continues to rise,which is attracting more and more attention.Studies have shown that microbes are closely related to the metabolic diseases of pregnancy.The influence of gestation hyperglycemia on maternal body is abnormal glucose metabolism,cardiovascular disease,metabolic syndrome,and postpartum depression.The influence of the offspring is manifested by fetal death,malformation and other adverse pregnancy outcomes as well as the long-term occurrence of abnormal glucose metabolism and obesity.Early diagnosis of GDM has important clinical significance.Blood glucose management should run through the whole course of pre-pregnancy,pregnancy and postpartum.Good blood glucose control can improve the near and long term prognosis of mother and infant.Lifestyle intervention is the basic strategy of blood glucose management.Insulin is the first choice for drug treatment.The selection of basic insulin,which accords with the physiological secretion characteristics,is optimized treatment strategy.In this paper,the relevant research status at home and abroad is reviewed,in order to provide useful reference for clinical diagnosis and treatment.
刘桂萍;张林;张国领. 妊娠合并糖尿病的临床研究现状[J]. 中国当代医药, 2018, 25(26): 46-49.
LIU Gui-ping;ZHANG Lin;ZHANG Guo-ling. Clinical research status of diabetes in pregnancy. 中国当代医药, 2018, 25(26): 46-49.
Xu Y，Wang L，He J，et al.Prevalence and control of diabetes in Chinese adults[J].JAMA，2013，310（9）：948-959.
[5]
Benhalima K，Leuridan L，Calewaert P，et al.Glucose intolerance after a recent history of gestational diabetes[J].Int J Endocrinol，2014，2014：727652.
[1]
Guariguata L，Linnenkamp U，Beagley J，et al.Global estimates of the prevalence of hyperglycaemia in pregnancy[J].Diabetes Res Clin Pract，2014，103（2）：176-185.
[3]
Zhu W，Yang H，Wei Y，et al.Evaluation of the value of fasting plasma glucose in the first prenatal visit to diagnose gestational diabetes mellitus in China[J].Diabetes Care，2013，36（3）：586-590.
[4]
Bassols J，Serino M，Carrerasbadosa G，et al.Gestational Diabetes is associated with changes in Placental Microbiota and Microbiome[J].Pediatric Res，2016，80（6）：777-784.
[6]
Leuridan L，Wens J，Devlieger R，et al.Glucose intolerance in early postpartum in women with gestational diabetes：who is at increased risk?[J].Prim Care Diabetes，2015，9 （4）：244-252.
[7]
Tobias DK，Stuart JJ，Li S，et al.Association of history of gestational diabetes with long-term cardiovascular disease risk in a large prospective cohort of US women[J].JAMA Intern Med，2017，177（12）：1735-1742.
[8]
Goueslard K，Cottenet J，Mariet AS，et al.Early cardiovascular events in women with a history of gestational diabetes mellitus[J].Cardiovase Diabetol，2016，15（1）：15.
[9]
Xu Y，Shen S，Sun L，et al.Metabolic syndrome risk after gestational diabetes：a systematic review and meta-analysis[J].PLoS One，2014，9（1）：e87863.
[10]
Stefanie NH，Germaine MB，Shristi R，et al.A longitudinal study of depression and gestational diabetes in pregnancy and the postpartum period[J].Diabetologia，2016，59（12）：2594-2602.
[11]
Eriksson UJ，Parri W.The status of diabetic embryopathy[J].Ups J Med Sci，2016，121（2）：96-112.
[12]
Popova P，Tkachuk A，Dronova A，et al.Fasting glycemia at the first prenatal visit and pregnancy outcomes in russian women[J].Minerva Endocrinol，2016，41（4）：477-485.
[13]
Sesmilo G，Meler E，Perea V，et al.Maternal fasting glycemia and adverse pregnancy outcomes in a mediterranean population[J].Acta Diabetol，2017，54（3）：293-299.
[14]
Liu B，Geng H，Yang J，et al.Early pregnancy fasting plasma glucose and lipid concentrations in pregnancy and association to offspring size：a retrospective cohort study[J].BMC Pregnancy Childbirth，2016，16（1）：56-63.
[15]
Wang C，Zhu W，Wei Y，et al.The predictive effects of early pregnancy lipid profiles and fasting glucose on the risk of gestational diabetes mellitus stratified by body mass index[J].J Diabetes Res，2016，（8）：1-8.
Liu B，Yun X，Ying Z，et al.Early diagnosis of gestational diabetes mellitus（EDoGDM） study：a protocol for a prospective，longitudinal cohort study[J].BMJ Open，2016，6（11）：e012315.
[22]
Wang C，Yang HX.Diagnosis，prevention and management of gestational diabetes mellitus[J].Chronic Dis Transl Med，2016.2（4）：199-203.
Balsells M，Garcia-Patterson A，Sola J，et al.Glibenclamide，metformin，and insulin for the treatment of gestational diabetes：a systematic review and meta-analysis[J].Bir Med J，2015，70（5）：h102.
[25]
李章芳，沈洁.妊娠合并糖尿病人群如何合理选择降糖药[J].药品评价，2015，（3）：26-29.
[26]
Herrera KM，Rosenn BM，Foroutan J，et al.Randomized controlled trial of insulin detemir versus NPH for the treatment of pregnant women with diabetes[J].Am J Obstet Gynecol，2015，213（3）：426.
[27]
Hod M，Mathiesen ER，Jovanovic L，et al.A random ized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes[J].J Matern Fetal Neonatal Med，2014，27（1）：7-13.
[28]
Kimberly MH，Barak MR，Janelle F，et al.Randomized controlled trial of insulin detemir versus NPH for the treatment of pregnant women with diabetes[J].Am J Obstet Gynecol，2015，213（3）：1-7.
京公网安备 11010502046607号