Abstract：Objective To observe the influence of Liraglutide combined with Metformin treating polycystic ovary syndrome(PCOS)on the morbidity of gestational diabetes mellitus(GDM).Methods Sixty-pregnancy women diagnosed with PCOS who visited the Department of Endocrinology in our hospital from October 2014 to April 2017 were enrolled and divided into the experimental group(n=21)and the control group(n=39)based on whether Liraglutide was used or not before pregnancy.In the experimental group,participants were treated with Liraglutide combined with Metformin for more than 6 months before pregnancy and continued with Metformin after pregnancy.In the control group,oral administration of Metformin alone was adopted for these PCOS women,and did not continue Metformin treatment during pregnancy.All subjects were provided with oral glucose tolerance test(OGTT)during pregnancy.The incidence of GDM,cesarean section rate,premature birth rate and weight change were observed in the two groups.Results The weight loss rate of the experimental group before pregnancy was higher than that of the control group,with significant difference(P＜0.05).The incidence of GDM in the experimental group was lower than that in the control group,with significant difference(P＜0.05).The body weight of the experimental group at weeks 24,32,and 36 weeks of the pregnancy was lower than that of the control group,with significant difference(P＜0.05).Conclusion Liraglutide combined with Metformin can preventively reduce the morbidity of GDM in PCOS women.
胡晓娜. 利拉鲁肽联合二甲双胍治疗多囊卵巢综合征对妊娠期糖尿病发病率的影响[J]. 中国当代医药, 2018, 25(10): 19-22.
HU Xiao-na. Influence of Liraglutide combined with Metformin in the treatment of polycystic ovary syndrome on the morbidity of gestational diabetes mellitus. 中国当代医药, 2018, 25(10): 19-22.
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