替罗非班在急性脑梗死患者支架取栓术中的临床疗效及安全性

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摘要目的探讨替罗非班在急性脑梗死患者支架取栓术中的临床疗效及安全性。方法选取2016年1月～2017年11月我院收治的急性脑梗死患者支架取栓术中应用替罗非班治疗的31例患者临床资料进行回顾性分析，按照术中是否应用替罗非班分为对照组（12例）和观察组（19例），对照组单纯应用支架取栓治疗，观察组在支架取栓术中应用替罗非班治疗。比较两组治疗前后血小板聚集水平，NIHSS、BI评分，不良反应发生率的情况。结果治疗前，两组患者血小板聚集水平的比较，差异无统计学意义（P＞0.05）；两组患者治疗后24 h的血小板聚集水平均显著低于治疗前，且观察组的血小板聚集水平显著低于对照组，差异均有统计学意义（P＜0.05）。术前，两组患者的NIHSS评分、BI评分的比较，差异均无统计学意义（P＞0.05）；术后3周，两组患者的NIHSS评分均低于术前，且术后3个月两组患者的BI评分均高于术前，差异均有统计学意义（P＜0.05）；观察组术后3周NIHSS评分低于对照组，且术后3个月 BI评分均高于对照组，差异均有统计学意义（P＜0.05）。对照组患者出现症状性出血1例，研究组患者出现无症状性出血1例，无死亡病例，两组患者治疗后颅内出血发生率的比较，差异无统计学意义（P＞0.05）。结论替罗非班在急性脑梗死患者支架取栓术中能够降低血小板聚集率，提高血管再通率，改善患者预后，安全性高。

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	黎炳润
	罗赛华
	江庆炎

关键词 ：急性脑梗死, 支架取栓, 替罗非班, 血小板聚集率

Abstract：Objective To investigate the clinical efficacy and safety of tirofiban in patients with acute cerebral infarction undergoing stenting.Methods The clinical data of 31 patients with acute cerebral infarction admitted to our hospital from January 2016 to November 2017 who were treated with tirofiban during stenting were retrospectively analyzed.according to whether tirofiban was used during the operation,they were divided into control group (12 cases)and observation group (19 cases).The control group was treated with stenting alone,while the observation group was treated with tirofiban during stenting.The platelet aggregation level,nihss and bi scores and the incidence of adverse reactions were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in platelet aggregation between the two groups (P＞0.05).The platelet aggregation level of 24 h was significantly lower than that before treatment in two groups,and the platelet aggregation level in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).Before surgery,there was no significant difference in NIHSS score and BI score between the two groups.At 3 weeks after surgery,the NIHSS scores of the two groups were lower than those before surgery,and the BI scores of the two groups were higher than those before surgery 3 months after surgery,the difference was statistically significant(P＜0.05).NIHSS scores in the observation group were lower than those in the control group 3 weeks after surgery,and BI scores were higher than those in the control group 3 months after surgery,the difference was statistically significant(P＜0.05).There was 1 case of symptomatic bleeding in the control group,1 case of asymptomatic bleeding in the study group,and no death.There was no statistical difference in the incidence of intracranial hemorrhage between the two groups after treatment(P＞0.05).Conclusion Tirofiban can reduce platelet aggregation rate,improve vascular recanalization rate,improve the prognosis of patients with acute cerebral infarction during stenting,and has high safety.

Key words： Acute cerebral infarction')" href="#">

Acute cerebral infarction Sent thrombectomy Tirofiban Platelet aggregation rate

基金资助:广东省湛江市非资助科技攻关项目（2017B101）

引用本文:

黎炳润;罗赛华;江庆炎. 替罗非班在急性脑梗死患者支架取栓术中的临床疗效及安全性[J]. 中国当代医药, 2018, 25(23): 50-52.
LI Bing-run;LUO Sai-hua;JIANG Qing-yan. Clinical efficacy and safety of tirofiban in patients with acute cerebral infarction undergoing stenting. 中国当代医药, 2018, 25(23): 50-52.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2018/V25/I23/50

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