Abstract：Objective To investigate the relationship between homocysteine plus low density lipoprotein levels and intracranial arterial stenosis in patients with ischemic stroke.Methods A total of 60 cases as observation group were selected from patients with ischemic stroke who were treated in department of neurology in our hospital from January 2013 to December 2014.Meanwhile,60 normal were selected as the control group at the same time.The blood samples were tested for homocysteine and low density lipoprotein.Head and neck CE-MRA weral e used to check the vascular condition of intracranial arteries.Results The blood homocysteine level in the observation group was(18.19±6.23)μmol/L,and wihch was higher than that in the control group([11.23±5.46] μmol/L)(P<0.05).The patients in,intracranial artery stenosis group were subdivided into light,medium and severe groups.The homocysteine level in severe stenosis group was statistically significant than that in other two groups(P<0.05).There was no statistical difference in LDL levels between three subgroups(P＞0.05).Homocysteine was positively correlated with the degree of cerebral vascular stenosis(r=0.68,P<0.05).Multiple regression analysis showed that hypertension and homocysteine levels were closely related to cerebrovascular stenosis.Conclusion Blood homocysteine and low density lipoprotein level both are risk factors for cerebral vascular stenosis,and high homocysteine is highly correlated with cerebral vascular stenosis.Prevention and intervention for high level of homocysteine should be timely considered to avoid the occurrence of ischemic cerebrovascular disease.
Wang T，Wang Q，Wang Z，et al.Diagnostic value of the combinedmeasurementofserumHcy，serumCysCandurinary microalbumin in type 2 diabetes mellitus with early complicating diabetic nephropathy[J].ISRN Endocrinol，2013，2013（10）：407-452.
[4]
Song IU，Kim JS，Park IS，et al.Clinical significance of homocysteine（hcy）on dementia in Parkinson's disease（PD）[J].Arch Gerontol Geriart，2013，57（3）：288-291.
[5]
McCully KS.Vascular pathology of homocysteinemia;implications for the pathogenesis of arteriosclerosis[J].Am J Pathol，1969，56（1）：111-128.
[6]
Cui R，Moriyama Y，Koike KA.Serum total homocysteine concentrations and risk of mortality from stroke and coronary heart disease in Japanese：the JACC study[J].Atherosclerosis，2008，198（2）：412-418.
[7]
Suwanwela NC，ChutinetrA.Risk factors for atherosclerosis of cervicocerebral arteries：intracranial versus extracranial[J].Neuroepidemiology，2003，22（1）：37-40.
[8]
Koenig W.Fibrin（ogen）in cardiovascular disease： an update[J].Thromb Haemast，2003，89（4）：601-609.
[9]
Baszczuk A.Kopczynski Z，Thielemann A.Endothelial dysfunction in patients with primary hypertension and hyperhomocysteinemia[J].Postepy Hig Med Dosw（Online），2014，68：91-100.
[10]
TsudaK.Plasmahomocysteinelevelsandendothelialdysfunction in cerebro-and cardiovascular disease in the metabolic syndrome[J].Am J Hypertens，2015，28（12）：1489.
[11]
Wang XC，Sun WT，Yu CM，et al.ER stress mediates homocysteine-induced endothelial dysfunction：modulation of IKCa and SKCa channels[J].Atherosclerosis，2015，242（1）：191-198.
Van der Heyden J，Van Neerven D，Sonker U，et al.Carotid artery stenting and cardiac surgery in symptomatic patients[J].JACC Cardiovasc Interv，2011，4（11）：1190-1096.
[19]
Alikhan R， Cohen AT，Combe S，et al.Risk factors for venous thromboembolism in hospitalized patients with acute medical illness：analysis of the MEDENOX Study[J].Arch Intern Med，2004，164（9）：963-968.
[20]
Peralta CA， KateR，NewmanAB，et al.Systolic and diastolic blood pressure，incident cardiovascular events，and death in elderly persons：the role of functional limitation in the cardiovascular health study[J].Hypertension，2014，64（3）：472-480.
京公网安备 11010502046607号