Effect and safety study of glucocorticoid in different administration methods in the treatment of acute exacerbation of chronic obstructive pulmonary disease
ZHANG Shao-xin1 GUO Ling-ling2
1.Department of Infectious Disease,People′s Hospital of Lianxi District of Jiujiang City in Jiangxi Province,Jiujiang 332005,China;
2.Drug Rehabilitation Center of Jiujiang City in Jiangxi Province,Jiujiang 332012,China
Abstract：ObjectiveTo investigate the efficacy and safety of glucocorticoid in oral administration and intravenous infusion in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).MethodsA total of 102 patients with AECOPD who were enrolled in our hospital from October 2015 to December 2016 were selected as research objects.They were evenly divided into the oral administration group and the intravenous infusion group according to a random number table method.In the oral administration group,32 mg/d Methylprednisolone was used,while in the intravenous infusion group,Methylprednisolone via intravenous drip was adopted.The dose in the first three days was 1 mg/(kg·d),and 0.5 mg/(kg·d)from day 4 to day 7.After one-week treatment,the efficacy was assessed and the occurrence of adverse reactions in the two groups was compared.ResultsThere was no significant difference in the total effective rate between the two groups(P＞0.05).The level of PaO2and PaCO2after treatment in the two groups was significantly better than that before treatment,with significant difference (P＜0.01).There was no significant difference in the level of pH,PaO2and PaCO2before treatment and after treatment between the two groups(P＞0.05).There was no significant difference in the incidence of digestive tract reaction between the two groups(P＞0.05).The incidence rate of elevated blood glucose,elevated blood pressure,and pulmonary encephalopathy in the oral administration group was significantly lower than that in the intravenous infusion group,with significant difference (P＜0.05).ConclusionGlucocorticoid both in oral administration and in intravenous infusion obtain satisfactory effect on treating AECOPD,but the oral administration has less complications and higher safety.
张绍新;郭玲凌. 糖皮质激素不同给药方式治疗慢性阻塞性肺疾病急性加重期的效果和安全性研究[J]. 中国当代医药, 2017, 24(23): 46-48转65.
ZHANG Shao-xin;GUO Ling-ling. Effect and safety study of glucocorticoid in different administration methods in the treatment of acute exacerbation of chronic obstructive pulmonary disease. 中国当代医药, 2017, 24(23): 46-48转65.
Casaburi R，Briggs DD，Donohue JF，et al.The spirometric efficacy of once daly dosing with tiotropium in stable COPD：a 13-week multicenter trial.The US Tiotropium Study Group[J].Chest，2013，118（5）：1294-1302.
Criner GJ，Bourbeau J，Diekemper RL，et al.Prevention of acute exacerbations of COPD：American college of chest physicians and Canadian thoracic society guideline[J].Chest，2015，147（4）：894-942.
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