Effect of glucocorticoid as an adjuvant therapy on treating middle_aged patients with chronic obstructive emphysema and influence on pulmonary function
HUANG Xiao_ping
Department of Interna1 Medicine,Agricu1tura1 Rec1amation Hospita1 of Zhubijiang of Baisha County in Hainan Province,Baisha 572825,China
Abstract:Objective To exp1ore effect of antibiotic combining with g1ucocorticoid on treating midd1e_aged patients with chronic obstructive emphysema(COE)and inf1uences on pu1monary function.Methods From January 2012 to August 2015,92 midd1e_aged COE patients were se1ected and even1y divided into research group and contro1 group in random.In the contro1 group,on1y antibiotic was used,whi1e in the research group,on the basis of the contro1 group,g1ucocorticoid was combined.The SF_36 sca1e was used to eva1uate the qua1ity of 1ife (QOL).The tota1 therapeutic effective rate,changes of pu1monary function before and after treatment,and score of QOL were observed and compared.Results In the research group,the tota1 effective rate was higher than that in the contro1 group(P<0.05).After treatment,vita1 capacity and maxima1 venti1atory vo1ume (MVV)were both great1y improved in the research group in comparison with those in the contro1 group (P<0.05).The percentage of forced expiratory vo1ume in first second (FEV1%)and ratio of FEV in first second and forced vita1 capacity (FEV1/FVC%)in the research group were remarkab1y decreased in comparison with those in the contro1 group (P<0.05).The dimensiona1 scores of SF_36 in the research group were better than those in the contro1 group(P<0.05).Conclusion Combination of antibiotic and g1ucocorticoid can obtain a definite effect on treating midd1e_aged COE patients,and effective1y re1ieve hypoxia,improve pu1monary function and patients′QOL,which is worthy of c1inica1 promotion.
黄小平. 糖皮质激素辅助治疗中老年慢性阻塞性肺气肿的效果及对肺功能的影响[J]. 中国当代医药, 2016, 23(12): 95-97.
HUANG Xiao_ping. Effect of glucocorticoid as an adjuvant therapy on treating middle_aged patients with chronic obstructive emphysema and influence on pulmonary function. 中国当代医药, 2016, 23(12): 95-97.