Abstract：Objective To observe the phenomenon of abnorma1 g1ucose to1erance in patients with COPD，and to exp1ore the re1ationship between impaired g1ucose to1erance and Th1/Th2 1ymphocytes imba1ance.Methods Ora1 g1ucose to1erance test was carried out for 86 cases with COPD in stab1e stage from 1 January to 31 December 2015，fasting p1asma g1ucose （FPG）and 2 h p1asma g1ucose （2 hPG）were detected and compared with that of heath contro1 group.At the same time，the serum 1eve1 of IFN_γ and IL_4，which ref1ected the function of Th1 and Th2 1ymphocyte respective1y，were detected and compared with that of heath contro1 group.At 1ast，the corre1ation between IFN_γ and IL_4 and FPG and 2 hPG was studied.Results The 1eve1 of FPG and 2 hFPG was significant1y higher in COPD patients than that in hea1th contro1 group respective1y（P＜0.05）.The serum 1eve1 of IFN_γ increased and IL_4 decreased in COPD when compared with hea1th contro1 group（P＜0.05）.IFN_γ was positive1y corre1ated with FPG and 2 hPG in COPD patients（r= 0.4237，0.5316，P＜0.05）；IL_4 was negative1y corre1ated with FPG and 2 hPG in COPD patients（r=_0.3891，_0.3625，P＜0.05）.Conclusion An impaired g1ucose to1erance exists in stab1e COPD and the predominance of Th1 is responsib1e for this phenomenon.
Hodge G，Nairn J，Ho1mes M，et al.Increased intrace11u1ar T he1per 1 proinf1ammatory cytokine production in periphera1 b1ood，bronchoa1veo1ar 1avage and intraepithe1ia1 T ce11s of COPD subjects［J］.C1in Exp Immuno1，2007，150 （1）：22_29.
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