BiPAP机间歇通气联合纳络酮治疗慢性阻塞性肺疾病急性加重伴呼吸衰竭的效果分析

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摘要目的探讨采用BiPAP机间歇通气联合纳络酮治疗慢性阻塞性肺疾病急性加重期（AECOPD）伴呼吸衰竭的效果。方法选取2012年1月～2014年12月于本院住院治疗的46例AECOPD伴呼吸衰竭患者作为研究对象，随机分为BiPAP机通气组与对照组，各23例。对照组常规给予氧疗、抗感染、解痉、对症治疗，必要时行机械通气治疗。BiPAP机通气组在常规给予氧疗、抗感染、解痉、对症治疗的基础上，采用BiPAP无创呼吸机间歇通气联合纳络酮进行治疗。观察两组治疗前后的动脉血气分析变化和6 min步行距离变化。结果两组治疗后的PaO2水平高于治疗前，PaCO2水平低于治疗前，差异有统计学意义（P＜0.05）。BiPAP机通气组治疗后的PaO2水平高于对照组，PaCO2水平低于对照组，差异有统计学意义（P＜0.05）。两组治疗后的6 min步行距离长于治疗前，差异有统计学意义（P＜0.05）。BiPAP机通气组治疗后的6 min步行距离长于对照组，差异有统计学意义（P＜0.05）。BiPAP机通气组均不需要行气管插管和机械通气治疗。结论 BiPAP机间歇通气联合纳络酮治疗AECOPD呼吸衰竭患者有较好的效果，且无明显不良反应发生。

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	林秾威

关键词 ：间歇通气, 纳络酮, 慢性阻塞性肺疾病急性加重期, 6 min步行距离

Abstract：Objective To investigate the effect of BiPAP intermittent ventilation combined with Naloxone in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD)complicated with respiratory failure. Methods 46 patients with AECOPD complicated with respiratory failure who were hospitalized in our hospital from January 2012 to December 2014 were selected and randomly divided into the BiPAP ventilation group and the control group,23 cases in each group.The control group was given conventional oxygen therapy,anti-infection,antispasmodic,and symptomatic treatment,if necessary,the control group was given mechanical ventilation treatment.The BiPAP ventilation group was treated with intermittent ventilation by BiPAP non-invasive ventilator combined with Naloxone on the basis of the conventional oxygen therapy,anti-infection,antispasmodic,and symptomatic treatment.Changes in arterial blood gas analysis and changes in 6-minute walking distance before and after treatment were observed between the two groups.Results The level of PaO2in the two groups after treatment was higher than that before treatment,and the level of PaCO2in the two groups after treatment was lower than that before treatment,with significant difference(P＜0.05).The level of PaO2in the BiPAP ventilation group after treatment was higher than that in the control group,and the level of PaCO2in the BiPAP ventilation group after treatment was lower than that in the control group,with significant difference (P＜0.05).6-minute walking distance after treatment in the two groups was longer than that before treatment,with significant difference(P＜0.05).6-minute walking distance in the BiPAP ventilation group after treatment was longer than that in the control group,with significant difference (P＜0.05).There was no need for endotracheal intubation and mechanical ventilation in the BiPAP ventilation group.Conclusion BiPAP intermittent ventilation combined with Naloxone is effective in the treatment of patients with AECOPD complicated with respiratory failure and has no adverse reactions.

Key words： Intermittent ventilation Naloxone Acute exacerbation of chronic obstructive pulmonary disease 6-minute walking distance

引用本文:

林秾威. BiPAP机间歇通气联合纳络酮治疗慢性阻塞性肺疾病急性加重伴呼吸衰竭的效果分析[J]. 中国当代医药, 2017, 24(5): 31-33.
LIN Nong-wei. Analysis on the effect of BiPAP intermittent ventilation combined with Naloxone in the treatment of acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure. 中国当代医药, 2017, 24(5): 31-33.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I5/31

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