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2024 Vol. 31, No. 11
Published: 2024-04-18
 
 
4 Meta-analysis of the clinical effect of traditional Chinese medicine on chronic kidney disease
ZHOU Ting LEI Wenming FENG Wei LIU Ping HE Donghong
Objective To investigate the clinical efficacy of traditional Chinese medicine in the treatment of chronic kidney disease by systematic review and meta-analysis.Methods Domestic and foreign databases were searched by computer,and eligible literatures were selected according to inclusion and exclusion criteria.Meta-analysis was performed using RevMan5.3 software after literature data extraction and quality evaluation.Results Seventeen randomized controlled trials(RCT) were included,with a total of 1 151 patients,most of which were of low quality.The total effective rate (I2=33%,RR=1.31,95%CI: 1.22-1.40) and glomerular filtration rate (I2=50%, WMD=4.04,95%CI: 2.04-6.05) in experimental groups were higher than those in control group,serum creatinine (I2=29%, WMD=-15.42,95%CI: -18.32--12.51),urea nitrogen (I2=77%, WMD=-1.27,95%CI: -1.81--0.73),traditional Chinese medicine syndrome score (I2=89%,WMD=-6.97,95%CI: -9.47--4.47),24 h urinary protein quantity (I2=0%, WMD=-0.12,95%CI: -0.21--0.03) were lower than those of the control group,the differences were statistically significant (P ＜0.05).Conclusion Traditional Chinese medicine combined with western medicine conventional treatment of chronic kidney disease,the effect is better,can improve the symptoms of traditional Chinese medicine and kidney function.
2024 Vol. 31 (11): 4-08 [Abstract] ( 8 ) HTML (1 KB)  PDF (2128 KB)  ( 60 )
9 Observation on sterilization effect of volatile oils from four kinds of Xinyang genuine Chinese herbs
WANG Zexia GAO Ge DIAO Tingting QIAO Xinrong YAN Yuhan ZHANG Qiuhui LI Jiaxing LI Jingyi ZHU Nailiang
Objective To observe sterilization effect of volatile oils from four kinds of Xinyang genuine Chinese herbs(GCH)such as Agastache rugosa(Fisch.et Mey.)O.Ktze(A. rugosa),Atractylodes lancea(Thunb.)DC(A. lancea),Chrysanthemum indicum L(C. indicum L.)and Ranunculus ternatus Thunb.(R. ternatus).Methods Suspension quantitative germicidal test was used to observe sterilization effect of the single volatile oil and compound volatile oils from GCH such as Agastache rugosa (Fisch.et Mey.) O.Ktze (A. rugosa), Atractylodes lancea (Thunb.) DC (A. lancea), Chrysanthemum indicum L (C. indicum L.)and Ranunculus ternatus Thunb.(R. ternatus).Results The killing rates of Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa and Candida albicans exposed to solution containing ≥2.0%A. rugosa or C. indicum L.volatile oil for 10 minutes were ＞99.9%.The killing rates of four kinds of test bacteria exposed to solution containing≥1.0% A. rugosa and C. indicum L.compound volatile oils for 10 minutes were ＞99.9%.Conclusion The volatile oils of four GCH from Xinyang such as A. rugosa, A.lancea,C. indicum L.,R. ternatus have good sterilization effect against bacteria and fungi.While reducing the amount of volatile oil, A. rugosa and C. indicum L.compound volatile oils have a synergistic efficacy,which greatly improves the broad-spectrum bactericidal activity with good sterilization effect for popularization.But the sterilization effect of volatile oils from different GCH on different test bacteria were different.
2024 Vol. 31 (11): 9-13 [Abstract] ( 8 ) HTML (1 KB)  PDF (621 KB)  ( 10 )
14 Meta-analysis of efficacy and safety of indocyanine green fluorescence cholangiography in complex laparoscopic cholecystectomy
WU Linde1 TU Yonglang2▲ GAO Guohua1 LI Gang1
Objective To compare the efficacy and safety of indocyanine green (ICG) fluorescence cholangiography combined with laparoscopic cholecystectomy (LC)and conventional LC in the treatment of complicated LC.Methods Through the retrieval database,studies comparing the efficacy of ICG fluorescence cholangiography LC test group and conventional LC control group in complex LC from 2018 to 2022 were retrieved.After the quality of the included literature was evaluated and the relevant research data were extracted,RevMan Manager 5.4 was used for meta-analysis.Results A total of 14 articles were included in this study,including 1 116 cases.The analysis showed that compared with the conventional LC treatment group,the ICG combined LC group had shorter operation time(MD=-24.37,95%CI:-32.87 to-15.86)and less intraoperative blood loss(MD=-11.36,95%CI:-15.34 to-7.37),shorter time to recognize biliary structure(MD=-16.79,95%CI:-31.00 to-2.58),shorter postoperative hospital stay (MD=-0.61,95%CI:-1.13 to-0.09),shorter recovery time of anal exhaust function(MD=-2.61,95%CI:-5.40 to-0.17),lower total incidence of postoperative complications(OR=0.57,95%CI:0.16 to-0.44),and less hospitalization costs(MD=-1 549.69,95%CI:-2 647.34 to-452.04).There were no significant differences in postoperative drainage tube removal time and intraoperative conversion rate between the two groups (P＞0.05).Conclusion ICG cholangiography is safe and effective in LC for complex gallbladder diseases,which can reduce the risk of bile duct injury.
2024 Vol. 31 (11): 14-19转24 [Abstract] ( 8 ) HTML (1 KB)  PDF (1736 KB)  ( 8 )
20 Mining and analysis of the adverse event reports signals for Pralsetinib based upon FAERS
CHEN Xi DU Junnan
Objective Data analysis of Pralsetinib adverse event was conducted to explore the risk factors for serious adverse events.Methods According to the adverse reaction data of 12 quarters from the 3rd quarter of 2020 to the 2nd quarter of 2023 in FDA Adverse Event Reporting System(FAERS)database,reporting odds ratio(ROR)and proportional reporting ratio (PRR)methods were used to mine the risk signals of Pralsetinib adverse reaction.Results A total of 1 431 cases of adverse events of Pralsetinib were found by ROR and PRR methods,including some potential adverse event signals not mentioned in the instructions,such as increased markers of myocardial necrosis,pleural effusion,cognitive impairment, etc.,which should be vigilant in clinical administration.Conclusion ROR and PRR methods can effectively excavate the risk signal of Pralsetinib's adverse reactions,and provide reference for clinical safe drug use.
2024 Vol. 31 (11): 20-24 [Abstract] ( 9 ) HTML (1 KB)  PDF (688 KB)  ( 6 )
25 Application of autologous concentrated growth factor combined with Bovine Basic Fibroblast Growth Factor External Gel in wound repair
YANG Lutao CAO Qing
Objective To investigate the application effect of autologous concentrated growth factor (CGF) combined with Bovine Basic Fibroblast Growth Factor(bFGF)Gel in the repair of deep burn wounds.Methods A total of sixty four patients with deep burn admitted to the first people's Hospital of Jiujiang from February 2021 to August 2023 were selected as the research objects and they were divided into gel group(32 cases)and combined group(32 cases)according to random number table method.The gel group was treated with bFGF External Gel repair,and the combined group was treated with CGF combined with bFGF External Gel repair.The wound recovery,inflammatory factor levels (C-reactive protein [CRP],interleukin-6 [IL-6],white blood cell count [WBC]),pain,scar and treatment effect of the two groups were compared.Results The total effective rate of the combined group was higher than that of the gel group,and the difference was statistically significant（P＜0.05).After treatment,the levels of CRP,IL-6 and WBC in the two groups were significantly lower than those before treatment,and the combined group was lower than that in the gel group,the differences were statistically significant (P＜0.05).There were statistically significant differences in pain scores,time points and interactions between the two groups(P＜0.05).After 7 and 14 days of treatment,the pain in the combination group was lower than that in the gel group,the difference was statistically significant(P＜0.05).After treatment,the scar pigmentation,blood circulation,scar texture,scar thickness and the total score of Vancouver Scar Scale (VSS)in the combined group were lower than those in the gel group,the differences were statistically significant (P＜0.05).Conclusion The application of CGF combined with bFGF gel in the repair of burn wound can not only accelerate the healing and repair of skin wound,reduce the level of serum inflammatory factors,reduce the pain of patients,but also reduce scar hyperplasia.
2024 Vol. 31 (11): 25-28 [Abstract] ( 8 ) HTML (1 KB)  PDF (531 KB)  ( 23 )
29 Clinical study on acupoint catgut embedding combined with standardized anti allergic therapy for chronic urticaria
SUN Ying CAO Shuyang LIU Jing MA Chunye TENG Qiunan
Objective To investigate the clinical effect of acupoint catgut embedding combined with standardized anti allergic treatment for chronic urticaria.Methods A total of 100 patients with chronic urticaria in Qiqihar Hospital of Traditional Chinese Medicine from May 2022 to May 2023 were selected as research subjects and divided into control group and treatment group by random number table method,with 50 patients in each group.Patients in the control group received standardized anti-sensitivity therapy,and patients in the treatment group received acupoint catgut embedding combined with standardized anti-sensitivity therapy.The symptom and sign score,clinical effective rate,serum immune factor index level,total incidence of adverse reactions and recurrence rate were compared between the two groups.Results The itch degree score,wind group severity score,interleukin-4 (IL-4),immunoglobulin E (IgE)after treatment,total incidence of adverse reactions and disease recurrence rate in observation group were lower than those in control group,and the differences were statistically significant(P＜0.05).The total effective rate and the expression level of interferon-γ(INF-γ) after treatment in the treatment group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Adopting acupoint catgut embedding combined with standardized anti allergic therapy for chronic urticaria can improve patients' clinical symptoms and signs,improve serum immune factor expression levels,reduce disease recurrence rate and incidence of adverse reactions.The clinical safety and effectiveness are high,and it is worth recommending.
2024 Vol. 31 (11): 29-32 [Abstract] ( 8 ) HTML (1 KB)  PDF (529 KB)  ( 6 )
33 Application effect of active heating humidification oxygen therapy technology in sequential oxygen therapy after tracheotomy and withdrawal in severe patients with brain diseases
LIANG Fuyuan WANG Weigui ZHONG Jian
Objective To analyze the application effect of active heating humidification oxygen therapy technology in sequential oxygen therapy for tracheotomy and withdrawal in severe patients with brain diseases.Methods A total of 80 patients with severe tracheotomy and ventilator assisted ventilation in the brain department who were to be withdrawn from Shunde Hospital,Guangzhou University of Chinese Medicine from January 2021 to October 2022 were selected as the study objects,and were divided into observation group and control group by random number table method,with 40 cases in each group.Patients in the observation group were treated with a high flow humidified oxygen therapy system,while patients in the control group were treated with a humid heat exchanger.The number of sputum blockage,degree of airway humidification,ICU stay time,heart rate(HR),respiratory rate(RR),arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide (PaCO2) and oxygenation index (OI) were compared between the two groups.Results The number of phlegm blockage after offline in the observation group was less than that in the control group,and the difference was statistically significant (P＜0.05).The degree of airway humidification in the observation group was better than that in the control group,the difference was statistically significant (P＜0.05).The duration of ICU stay in the observation group was shorter than that in the control group,and the difference was statistically significant (P＜0.05).HR,RR and PaCO2 in observation group were lower than those in control group at 1,12,24,48 and 72 hours after offline sequential oxygen therapy,while PaO2 and OI were higher than those in control group,with statistical significance (P＜0.05).Conclusion The active heating humidification oxygen therapy technology has a significant clinical effect in sequential oxygen therapy for patients undergoing gas resection after weaning,improving the success rate of weaning.After weaning,all clinical indicators of patients tend to be normal,and it has clinical application value.
2024 Vol. 31 (11): 33-36 [Abstract] ( 9 ) HTML (1 KB)  PDF (550 KB)  ( 25 )
37 Effect of low molecular weight heparin on the outcome of newborns with selective intrauterine growth restriction in monochorionic diamniotic
ZHU Huiting ZHANG Jinliang LAI Hua YANG Miaomiao

Objective To investigate the effects of low molecular weight heparin on neonatal outcomes of selective intrauterine growth restriction (sIUGR) in monochorionic diamniotic.Methods A total of 40 pregnant women with sIUGR treated in Jiangxi Provincial Maternal and Child Health Hospital from April 2021 to April 2023 were selected as research objects,and they were divided into control group(20 cases)and treatment group(20 cases)by random number table method.The control group was treated with fetal lung maturation drugs.Based on this,low molecular weight heparin was used in treatment group.The fetal growth and development parameters([long diameter of femur[FL],double parietal diameter[BPD],abdominal circumference [AC] and head circumference [HC]),maternal hemorheology indexes (hematocele volume [HCT],whole blood low tangential viscosity [WBLSV]and whole blood high tangential viscosity [WBHSV]),fetal umbilical artery flow indexes (resistance index [RI],pulsatile index [PI],systolic high blood flow velocity [S]/late diastolic high blood flow velocity[D])and neonatal outcomes(gestational age,length,weight,adverse outcomes at birth) were compared between the two groups.Results FL,BPD,AC and HC in treatment group were higher than those in control group,the differences were statistically significant (P＜0.05),RI,PI and S/D were lower than those in control group,the differences were statistically significant (P＜0.05).The HCT,WBLSV and WBHSV of pregnant women in the treatment group were lower than those in the control group,and the differences were statistically significant (P＜0.05).Gestational age,body length and body weight of newborns in the treatment group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of adverse outcome in the treatment group(5.00%)was lower than that in the control group(30.00%),and the difference was statistically significant(P＜0.05).Conclusion The use of low molecular weight heparin in the treatment of sIUGR can effectively regulate the hemorheology of pregnant women and the umbilical artery blood flow of the fetus,accelerate the growth and development of the fetus,and improve the outcome of the newborn.
2024 Vol. 31 (11): 37-41 [Abstract] ( 8 ) HTML (1 KB)  PDF (398 KB)  ( 24 )
42 Comparison of assisted reproductive outcomes between two commercial cultures
LIN Yunhong HUANG Pengyu SHI Hang DU Shengrong SUN Yan ZHENG Beihong
Objective To investigate the effect of different commercial culture media on the clinical and birth outcomes of in vitro cultured embryos.Methods The clinical data of 1 540 oocyte retrieval cycles meeting the inclusion criteria from January 2020 to October 2021 were analyzed retrospectively according to the use of different commercial culture media,including 831 cycles in Vitrolife group and 709 cycles in Cook group to compare the in vitro embryo development and clinical outcomes of the two groups.Results The D3 high-quality embryo rate (69.63%vs.67.54%),rate of blastocyst formation(53.47%vs.49.01%),rate of blastocyst formation can be utilized(46.72%vs.42.70%)and D5 rate of blastocyst formation can be utilized (35.03%vs.30.32%)in the Cook group were higher than those in the Vitrolife group,the differences were statistically significant (P＜0.05).Conclusion Culture media may affect the formation of high-quality embryos and blastocysts during in vitro insemination and embryo transfer cycles.
2024 Vol. 31 (11): 42-46 [Abstract] ( 12 ) HTML (1 KB)  PDF (761 KB)  ( 5 )
47 Analysis of the effect of Recombinant Human Interferon α1b Injection aerosol inhalation in the treatment of bronchiolitis in children and the improvement of respiratory function
LI Shijing
Objective To analyze the effect of Recombinant Human Interferon α1b Injection aerosol inhalation in the treatment of bronchiolitis in children and the improvement of respiratory function.Methods A total of 74 children with bronchiolitis admitted to Tengzhou Traditional Chinese Medicine Hospital from January 2019 to December 2020 were selected as the study objects,and were divided into control group and study group according to random number table method,with 37 cases in each group.The control group took the routine drugs,the research group took the routine drugs and Recombinant Human Interferon α1b Injection aerosol inhalation.Clinical symptom relief time,lung function,blood gas analysis indicators and inflammatory factors were observed.Results After treatment,the relief time of cough,wheezing,lung rale and three concave signs in the research group was shorter than control group,with statistically significant difference (P＜0.05);after treatment,the mean expiratory flow rate at 50%vital capacity (MEF50),forced expiratory volume in one second(FEV1),peak maximum expiratory flow rate(PEF)of the research group were higher than those of the control group,with statistically significant differences (P＜0.05);after treatment,respiratory resistance (Rrs)and carbon dioxide partial pressure(PaCO2)values in the research group were lower than those in control group;arterial oxygen partial pressure (PaO2)values in the research group were lower than those in control group,with statistically significant differences (P＜0.05);after treatment,interferon-γ (IFN-γ)and interleukin (IL)-10 values in the research group were higher than control group,IL-4 values in the research group were lower than control group,with statistically significant differences (P＜0.05).Conclusion The Recombinant Human Interferon α1b Injection aerosol inhalation can reduce the clinical symptom relief time and inflammatory factors,and improve the respiratory function,blood gas analysis indicators.It is worthy of application.
2024 Vol. 31 (11): 47-50 [Abstract] ( 8 ) HTML (1 KB)  PDF (408 KB)  ( 9 )
51 Effect of different implantation angles of microscrew implant anchorage on alveolar resorption and the incidence of complications in orthodontic patients
PENG Yi LI Qin ZHAO Xuchun
Objective To investigate the effect of different implantation angles of microscrew implant anchorage on alveolar resorption and the incidence of complications in orthodontic patients.Methods A total of 80 orthodontic patients who needed to be treated with retraction of anterior teeth and admitted to the Department of Stomatology at Pingxiang People's Hospital from January 2019 to December 2021 were selected as the study objects.They were divided into group A (at 30° to the alveolar surface,26 cases),group B (at 60° to the alveolar surface,29 cases)and group C(at 90°to the alveolar surface,25 cases)according to the implantation angle of microscrew implant anchorage.The stability of microscrew implant,alveolar resorptionand the incidence of complications were compared between the two groups.Results After applying 150 g of load,the microscrew implant loosening ratein of group B was lower than those in group A and group C,and the difference was statistically significant (P＜0.017).The absorption values of alveolar height and width in group B were lower than those in group A and group C,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence of complications among the groups(P＞0.05).Conclusion The stability of microscrew implanted at an angle of 60°to the alveolar surface is the best.This method can better reduce lateral and longitudinal alveolar resorption,without increasing the incidence of complications.Clinicians can consider this angle when implanting microscrew implant.
2024 Vol. 31 (11): 51-54 [Abstract] ( 10 ) HTML (1 KB)  PDF (505 KB)  ( 12 )
55 Comparison of therapeutic effect of phacoemulsification combined with goniosynechialysis or trabeculectomy in patients with glaucoma and cataract
WANG Xiujuan WU Yiqiang ZHAN Liyuan
Objective To explore the efficacy of phacoemulsification combined with goniosynechialysis or trabeculectomy in patients with glaucoma and cataract.Methods A total of 100 patients with glaucoma combined with cataract admitted to Department of Ophthalmology,NO.907 Hospital of Joint Logistics Support Force from January 2018 to March 2022 were selected as the study objects.They were divided into trabeculectomy group and goniosynechialysis group by random number table method,with 50 cases in each group.The trabeculectomy group underwent phacoemulsification combined with trabeculectomy,and the goniosynechialysis group underwent phacoemulsification combined with goniosynechialysis,and the follow-up was 1 month.The ocular indexes,corneal endothelial cell indexes and complications were compared between the two groups.Results One month after surgery,the visual acuity,anterior chamber depth,astigmatism and anterior chamber angle of the two groups were higher than before surgery,and the intraoculer pressure was lower than before surgery,the differences were statistically significant (P＜0.05).One month after surgery,the visual acuity,intraoculer pressure,anterior chamber depth and anterior chamber angle in trabeculectomy group were lower than those in goniosynechialysis group,and the differences were statistically significant(P＜0.05).One month after surgery,the ratio of hexagonal cells and coefficient of variation of cell area were higher than before surgery,and the density of corneal endothelial cells was lower than before surgery,with statistical significance (P＜0.05).One month after surgery,the ratio of hexagonal cells and the coefficient of variation of cell area in the goniosynechialysis group were higher than those in the trabeculectomy group,and the density of corneal endothelial cells was lower than that in the trabeculectomy group,with statistical significance (P＜0.05).The incidence of postoperative complications in goniosynechialysis group was lower than that in trabeculectomy group,and the difference was statistically significant (P＜0.05).Conclusion Phacoemulsification combined with goniosynechialysis or trabeculectomy has the same effect on visual acuity improvement in patients with glaucoma combined with cataract,and trabeculectomy has a more obvious effect on reducing intraocular pressure.Compared with trabeculectomy,phacoemulsification combined with goniosynechialysis causes more severe damage to corneal endothelial cells and fewer complications,so the appropriate operation should be selected according to the specific conditions of patients in clinical practice.
2024 Vol. 31 (11): 55-58 [Abstract] ( 10 ) HTML (1 KB)  PDF (510 KB)  ( 1 )
59 Clinical observation of the effect of root canal filling combined with traditional Chinese medicine in the treatment of periodontal and pulp lesions
JIANG Qiuhong1 NING Zhinan1 LIU Honghui2 YAN Haifei3 ZHANG Yonghui4 LIU Xiaotao1 ZHOU Siping4
Objective To investigate the clinical effect of root canal filling combined with traditional Chinese medicine in the treatment of periodontal and pulp lesions.Methods A total of 90 patients with combined periodontal and pulp lesions admitted to Xinyu Hospital of Traditional Chinese Medicine from April 2021 to July 2022 were selected as the study objects,and they were divided into control group (45 cases) and observation group (45 cases) according to random number table method.The control group was treated with root canal filling,and the observation group was treated with root canal filling combined with Chinese medicine.The therapeutic effect,pain degree,inflammatory factor level and periodontal clinical indexes were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P ＜0.05).Visual analogue scale (VAS) score,interleukin-1β (IL-1β),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in observation group were lower than those in control group at 3 months after treatment,with statistical significances(P＜0.05).The plaque index(PLI)and gingival index(GI)scores of the observation group were lower than those of the control group at 6 months after treatment,and the differences were statistically significant (P＜0.05).Conclusion The effect of root canal filling combined with traditional Chinese medicine in the treatment of periodontal and pulp lesions is better,which can reduce the degree of pain,reduce the level of inflammatory factors and improve the periodontal condition.
2024 Vol. 31 (11): 59-62 [Abstract] ( 9 ) HTML (1 KB)  PDF (540 KB)  ( 7 )
63 Application effect of combined lumbo-epidural anesthesia in painless delivery
HUANG Xin LYU Chun JIANG Junwen ZHANG Hongwen
Objective To study the application effect of combined lumbar-epidural anesthesia in painless delivery.Methods A total of 100 women with painless delivery admitted to the Second People's Hospital of Jingdezhen from January 2021 to December 2022 were selected as the study objects.They were divided into observation group (n=52) and control group(n=48)according to different anesthesia regimen.The control group received epidural anesthesia,and the observation group received lumbo-epidural anesthesia.The onset time of anesthesia effect,delivery duration,pain degree,anesthesia adverse reaction,pregnancy outcome and neonatal Apgar score were compared between the two groups.Results The onset time in the observation group was shorter than that in the control group,and the difference was statistically significant (P＜0.05).The duration of the first and second stages of delivery in the observation group was shorter than that in the control group,the difference was statistically significant (P＜0.05).There was no significant difference in the duration of the third stage of delivery between the two groups (P＞0.05).The pain scores 5,30 and 60 min after anesthesia in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The incidence of anesthesia related adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The Apgar score of neonates 1 min after birth in observation group was higher than that in control group,and the difference was statistically significant (P＜0.05).Conclusion In painless delivery,epidural anesthesia and combined lumbo-epidural anesthesia can both achieve analgesic effects,but the combined lumbo-epidural anesthesia has more obvious advantages,mainly reflect in the rapid effect of anesthesia,good analgesic effect during the operation,shorten the delivery duration,improve the safety of anesthesia,avoid related complications,and have clinical promotion value.
2024 Vol. 31 (11): 63-66 [Abstract] ( 8 ) HTML (1 KB)  PDF (481 KB)  ( 13 )
67 Application of tracheal extubation technique under deep anesthesia in pediatric anesthesia comfort medical treatment
ZHU Xiongwen LI Yuzhong ZHOU Nanxian KE Shao
Objective To explore the application value of tracheal extubation technology under deep anesthesia in pediatric anesthesia comfort medical treatment.Methods A total of 60 children who underwent surgical treatment in Heyuan Maternal and Child Health Hospital from July 2022 to July 2023 were selected as the study objects,and they were divided into observation group(n=30)and control group(n=30)according to random number table method.Both groups of children were operated under tracheal intubation and general anesthesia.During anesthesia resuscitation after operation,the observation group was extubed under deep anesthesia,while the control group was extubed after waking up.The heart rate(HR),mean arterial pressure (MAP),agitation,the number of emergency airway management and the total incidence of adverse reactions after extubation were compared between the two groups.Results The HR and MAP of the observation group were higher than those of the control group at extubation,and the differences were statistically significant (P＜0.05).The sedation-agitation score (SAS)of the observation group was lower than that of the control group at extubation,5 min after waking up and returning to the ward,and the difference was statistically significant(P＜0.05).The rate of emergency airway treatment and the total incidence of adverse reactions after extubation in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion The application of trachea extubation under deep anesthesia in pediatric anesthesia can reduce postoperative agitation and adverse reactions,increase perioperative comfort and safety of children,and is worthy of clinical promotion.
2024 Vol. 31 (11): 67-70 [Abstract] ( 8 ) HTML (1 KB)  PDF (444 KB)  ( 10 )
71 Effect of Hedan Capsules combined with Atorvastatin Calcium on blood lipids and inflammatory factors in elderly patients with hypertension and hyperlipidemia
LIN Lu ZHANG Chuanlin ZHANG Huayan ZHANG Pei XU Can ZHANG Ling
Objective To explore the therapeutic effect of Hedan Capsules combined with Atorvastatin Calcium on elderly patients with hypertension combined with hyperlipidemia.Methods A total of 92 elderly patients with hypertension combined with hyperlipidemia admitted to the First Affiliated Hospital of Jiangxi Medical College from October 2019 to September 2021 were selected as the study objects,with 46 cases in each group according to the computer random number method.The control group received Atorvastatin Calcium treatment,and the observation group was treated with Hedan Capsules on the basis of the control group.The clinical efficacy,changes of lipid and inflammatory factors and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group,and the incidence of adverse reactions was lower than that of control group,the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in blood lipid index and inflammatory factor level between the two groups(P＞0.05).After treatment,the high density lipoprotein cholesterol(HDL-C)of the observation group was higher than that of the control group,while the total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),hypersensitive C-reactive protein (hs-CRP),interleukin-1 (IL-1) and interleukin-6 (IL-6) of the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).Conclusion Hedan Capsules combined with Atorvastatin Calcium in the treatment of elderly patients with hypertension and hyperlipidemia can effectively relieve the level of inflammatory factors and reduce the level of blood lipids,and can improve clinical efficacy and safety,with good application value,worthy of clinical promotion.
2024 Vol. 31 (11): 71-74 [Abstract] ( 8 ) HTML (1 KB)  PDF (507 KB)  ( 15 )
75 Effect of Valsartan on the improvement of the condition and serum homocysteine and matrix metalloproteinase-9 levels in elderly patients with essential hypertension and mild cognitive impairment
LI Yuning1 LIU Yating1 YANG Dong2 ZHANG Wenhua3 ZENG Ni4 CAI Yamin1▲
Objective To explore the effect of Valsartan on the condition improvement and serum homocysteine (Hcy)and matrix metalloproteinase-9(MMP-9)levels in elderly patients with essential hypertension and cognitive dysfunction.Methods A total of 142 elderly patients with essential hypertension combined with mild cognitive impairment admitted to the 921st Hospital of Joint Logistic Support Force of PLA from January 2019 to December 2022 were selected as the study objects,and were divided into observation group and control group by random number table method,with 71 cases in each group.The observation group was treated with Valsartan Capsules,and the control group was treated with Levamlodipine Besilate.The changes of heart rate,blood pressure,cognitive function,serum Hcy and MMP-9 levels before and after treatment were observed and compared between the two groups.Results There was no significant difference in heart rate between and within two groups before and after treatment (P＞0.05).There was no significant difference in the levels of systolic and diastolic blood pressure between the two groups before treatment (P＞0.05).The systolic blood pressure of the observation group was lower than that of the control group after treatment,and the difference was statistically significant (P＜0.05).However,there was no significant difference in diastolic blood pressure between the two groups after treatment (P＞0.05).There was no significant difference in the scores and total scores of cognitive function between the two groups before treatment (P＞0.05).After treatment,the four dimensions of delayed recall,abstraction,attention and language and the total score of cognitive function in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in naming,orientation,visual spatial and executive function scores between the two groups after treatment(P＞0.05).There was no significant difference in serum Hcy and MMP-9 levels between the two groups before treatment (P＞0.05),but the serum Hcy and MMP-9 levels in the observation group were lower than those in the control group after treatment,and the differences were statistically significant(P＜0.05).Conclusion In elderly patients with essential hypertension with mild cognitive dysfunction,Valsartan and Levamlodipine Besilate can reduce blood pressure,improve cognitive dysfunction,and reduce serum Hcy and MMP-9 levels on average.In comparison,Valsartan has more obvious effects,which is worthy of clinical promotion and implementation.
2024 Vol. 31 (11): 75-79 [Abstract] ( 8 ) HTML (1 KB)  PDF (558 KB)  ( 8 )
80 Effect of intensive assistance resident pharmacist intervention on the application of proton pump inhibitors in Class I incision surgery
WEN Haibo1 ZHENG Jinkun1 LI Qingde1 ZHU Lanzhen2
Objective To study the application effect of proton pump inhibitors(PPIs)injection in three types of type Ⅰincision surgery.Methods A total of 160 surgical inpatients admitted to the Lechang People's Hospital from January to December 2020 were selected as the control group,and 160 surgical inpatients admitted from January to December 2021 were selected as the intervention group.The control group adopted conventional management methods,and the intervention group adopted the management mode of close assistance and resident pharmacist intervention.The use of PPIs and the irrational use of PPIs in the two groups were analyzed.Results The utilization rate of PPIs injection in the intervention group was 37.5%,lower than that in the control group(77.5%),and the difference was statistically significant(P＜0.05).The irrational utilization rate of PPIs injection in the intervention group was 30.6%,lower than that in the control group (50.0%),and the difference was statistically significant(P＜0.05).The duration of PPIs injection in the intervention group was(2.06±2.80)d,which was lower than that in the control group (4.78±3.38) d,and the difference was statistically significant (P＜0.05).Conclusion The use of PPIs injection in three kinds of type Ⅰincision surgery can help pharmacists to intervene scientifically and promote the rational use of PPIs injection to achieve satisfactory results.
2024 Vol. 31 (11): 80-83 [Abstract] ( 8 ) HTML (1 KB)  PDF (511 KB)  ( 9 )
84 Application effect of Xihuang Capsules combined with teng medicine external application in the treatment of pelvic inflammatory mass
LIU Rongfang CHEN Lili YE Tingting TU Yunxia HUA Jinren PAN Mei MEI Tong
Objective To explore the effect of Xihuang Capsules combined with teng medicine external application on pelvic inflammatory mass.Methods A total of 60 patients with pelvic inflammatory mass admitted to Jiangxi Maternal and Child Health Hospital from December 2020 to August 2022 were selected as the research objects,and they were divided into control group(30 cases)and experimental group(30 cases)according to random number table method.The control group received simple teng medicine external application,and the experimental group received Xihuang Capsules on this basis.The clinical efficacy,traditional Chinese medicine symptom score and mass diameter of the two groups were compared.Results The total effective rate of experimental group was higher than that of control group,the difference was statistically significant(P＜0.05).The symptom scores of lumbosacral soreness,lower abdominal bearing-down pain or tingling,high leucorrhea amount,menstrual disorder,fatigue and low fever in experimental group were lower than those in control group after treatment,and the differences were statistically significant(P＜0.05).The mass diameter of experimental group was smaller than that of control group after treatment,and the difference was statistically significant(P＜0.05).Conclusion Xihuang Capsules combined with teng medicine external application in the treatment of pelvic inflammatory mass patients,the effect is good,can significantly improve symptom and reduce the mass,comprehensive efficacy is high.
2024 Vol. 31 (11): 84-87 [Abstract] ( 9 ) HTML (1 KB)  PDF (590 KB)  ( 8 )
88 Clinical study on the treatment of meridian diarrhea with Modified Xiaochaihu Decoction combined with traditional Chinese medicine Reyanbao
WANG Zhiliang1 HU Lingfei2▲
Objective To explore the clinical effect of Modified Xiaochaihu Decoction combined with traditional Chinese medicine Reyanbao in the treatment of menstrual diarrhea.Methods Sixty patients with menstrual diarrhea treated in Fuzhou Traditional Chinese Medicine Hospital from January 2022 to September 2023 were selected as the study objects,and were divided into control group(30 cases)and observation group(30 cases)according to random number table method.The control group was treated with Modified Xiaochaihu Decoction and the observation group was treated with traditional Chinese medicine Reyanbao in addition.Both groups were treated for 2 weeks.The clinical efficacy,clinical symptom score,diarrhea improvement time,defecation recovery time,quality of life,psychological state and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).After treatment,the scores of abdominal pain,diarrhea,abdominal distension and fecal characteristics of the observation group were (0.53±0.12),(0.69±0.14),(0.43±0.08)and (4.01±0.49)points,which were lower than (0.79±0.15),(0.95±0.18),(0.57±0.11) and (4.84±0.53) points of the control group,the differences were statistically significant (P＜0.05).The improvement time of diarrhea and the recovery time of defecation in the observation group were (1.58±0.23) and (2.35±0.32) days,which were shorter than (3.22±0.37) and (4.85±0.45)days of the control group,and the differences were statistically significant (P ＜0.05).The quality of life scores in various fields of the observation group after treatment were(89.65±5.32),(90.41±4.25),(88.74±5.33)and(91.32±3.57)points,which were higher than(81.41±5.25),(82.64±4.85),(80.39±5.25)and(83.04±4.71)points of the control group,the differences were statistically significant (P＜0.05).After treatment,the scores of Hamilton anxiety scale (HAMA)and Hamilton depression scale(HAMD)in the observation group were(7.03±1.05)and (8.12±1.13) points,which were lower than(9.65±1.13)and(10.52±1.25)points in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of Modified Xiaochaihu Decoction and traditional Chinese medicine Reyanbao can improve the therapeutic effect of menstrual diarrhea,alleviate disease symptoms,shorten the time for bowel movements to return to normal,correct abnormal psychological states,improve quality of life,and be safe and reliable.
2024 Vol. 31 (11): 88-91转96 [Abstract] ( 8 ) HTML (1 KB)  PDF (601 KB)  ( 4 )
92 Analysis of clinical application of Taichong Point in Great Compendium of Acupuncture and Moxibustion
LIU Jiajia HE Huiying CHEN Cui TAN Tao
By sorting out the relevant articles of Taichong point in Great Compendiun of Acupuncture and Moxibustion and combining with recent clinical research,this research discusses and analyzes the naming,positioning,acupuncture and moxibustion methods of Taichong point and the clinical application of acupuncture and moxibustion,in order to provide theoretical basis and support for clinical and experimental research.The Foot Jueyin Liver Meridian runs from the feet to the chest and abdomen,belonging to the liver meridian and gallbladder,and is connected to the lungs,stomach,kidneys,brain,throat,eyes,lips,and genital organs.The Taichong acupoint is located in the dorsum of the foot area,and the operating methods are mostly acupuncture and moxibustion.Clinical operations are mostly diarrhea.The Taichong acupoint,as the original and acupoint of the Foot Jueyin Liver Meridian,belongs to the earth acupoint of the Wood Meridian in the Five Elements.Its efficacy is mainly related to its positioning,meridian distribution,and acupoint properties.It has functions such as soothing the liver and regulating qi,promoting blood circulation and regulating blood circulation,and relieving pain through meridians.When used in conjunction with other acupoints,it can treat internal medicine related diseases (liver and gallbladder diseases,spleen and stomach diseases,kidney system diseases,limb meridian diseases),as well as gynecological and surgical diseases.Taichong point is a commonly used acupoint in clinical practice,and is commonly used in modern clinical practice for gynecological diseases,limb meridian diseases,and emotional diseases.
2024 Vol. 31 (11): 92-96 [Abstract] ( 8 ) HTML (1 KB)  PDF (637 KB)  ( 3 )
97 Clinical effect of Jianpi Qutan Huashi Huayu Decoction combined with intensive lifestyle intervention in the treatment of patients with abdominal obesity and the impact on glucose and lipid metabolism
HUANG Weizhen PENG Juan▲ WU Chunyu
Objective To observe the clinical effect of Jianpi Qutan Huashi Huayu Decoction combined with intensive lifestyle intervention in the treatment of patients with abdominal obesity,and the impact on glucose and lipid metabolism.Methods A total of 200 patients with abdominal obesity who were admitted to Xinyu Hospital of Traditional Chinese Medicine from January 2021 to June 2023were selected as the study objects.They were divided into a control group and an observation group according to the order of treatment,with 100 cases in each group.The control group was given intensive lifestyle intervention.On this basis,the observation group was treated with Jianpi Qutan Huashi Huayu Decoction.The two groups of patients were followed up for 3 months,and the effective rate was evaluated.Changes in waist circumference(WC),body mass index (BMI),total cholesterol (TC),triglyceride (TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol (HDL-C),glycosylated hemoglobin (HbA1c)and fasting blood glucose were compared between the two groups.Results After treatment,the total effective rate in the observation group was 80.00%,higher than 64.00%in the control group,and the difference was statistically significant (P＜0.05).After treatment,WC and BMI in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of TC,TG,LDL-C,HbA1c and fasting blood glucose in the observation group were lower than those in control group,and the differences were statistically significant(P＜0.05).Conclusion Jianpi Qutan Huashi Huayu Decoction combined with intensive lifestyle interventionis effective in the treatment of abdominal obesity,which can decrease BMI and WC,and correct abnormal glucose and lipid metabolism.
2024 Vol. 31 (11): 97-100 [Abstract] ( 8 ) HTML (1 KB)  PDF (588 KB)  ( 12 )
101 Clinical observation of Phloroglucinol Injection combined with hot sensitive moxibustion in the treatment of epigastric pain
HU Gusheng1 YU Minmin2 LI Gang3
Objective To explore the clinical efficacy of Phloroglucinol Injection combined with hot sensitive moxibustion in the treatment of epigastric pain.Methods A total of 52 patients with epigastric pain admitted to Jiujiang Traditional Chinese Medicine Hospital from January 2021 to August 2023 were selected as the study objects,and were divided into control group and observation group by random number table method,with 26 cases in each group.The control group was treated with Phloroglucinol Injection,while the observation group was treated with hot sensitive moxibustion.Clinical efficacy,pain intensity,pain duration,and adverse reactions were compared between two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The pain intensity scores of the two groups after treatment were lower than before treatment,and the difference was statistically significant (P＜0.05).The pain intensity score of the observation group after treatment was lower than that of the control group,and the difference was statistically significant (P＜0.05).The duration of pain in the observation group was shorter than that in the control group,and the difference was statistically significant (P＜0.05).The comparison of pain intensity score time,inter group,and interaction between the two groups showed statistically significant differences(P＜0.05).No significant adverse reactions were observed in both groups.Conclusion The combination of Phloroglucinol Injection and hot sensitive moxibustion in the treatment of epigastric pain can quickly and effectively alleviate the degree of pain in patients,reduce the duration of pain,and is safe and effective.It is worth promoting.
2024 Vol. 31 (11): 101-104 [Abstract] ( 8 ) HTML (1 KB)  PDF (446 KB)  ( 1 )
105 Effect of Bazhen Decoction combined with chemotherapy on acute leukemia
YANG Chao1 GUO Sufen2 ZHANG Mingyu3 YAN Wenting4 ZHANG Jingwen3 GAI Xinxin4▲
Objective To explore the effect of Bazhen Decoction combined with chemotherapy on acute leukemia.Methods From March 2021 to March 2023,72 patients with newly diagnosed or relapsed acute leukemia were selected as research objects,and they were divided into control group(36 cases)and experimental group(36 cases)according to random number table method.The control group were treated with chemotherapy alone,while patients in the experimental group were treated with Bazhen Decoction on the basis of chemotherapy.The remission rate of chemotherapy,incidence of chemotherapy-related side effects and prognosis of the two groups were compared.Results The remission rate of chemotherapy in the experimental group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The incidence rates of gastrointestinal reaction,liver function loss and renal function injury in the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After chemotherapy,the values of Lactate dehydrogenase(LDH)and β2-microglobulin(β2-MG)in the experimental group were lower than those in the control group,and the differences were statistically significant (P ＜0.05).Conclusion Bazhen Decoction combined with chemotherapy is effective in the treatment of acute leukemia,which can significantly improve the remission rate,reduce the incidence of chemotherapy-related side effects and improve the prognosis of patients.
2024 Vol. 31 (11): 105-108 [Abstract] ( 10 ) HTML (1 KB)  PDF (447 KB)  ( 1 )
109 Diagnostic value of thromboela-stogram combined with platelet aggregation in recurrent spontaneous abortion
HUANG Jian
Objective To explore the diagnostic value of thromboela-stogram (TEG) combined with platelet aggregation function in recurrent spontaneous abortion (RSA).Methods Fifty patients with RSA admitted to Ganzhou Women and Children's Health Care Hospital from January 2021 to March 2022 were selected as the observation group,and 50 healthy women from the hospital during the same period were selected as the control group.TEG and platelet aggregation function were detected in both groups.The coagulation reaction time (R),blood cell agglutination time (K),blood clot formation rate(Angle),maximum blood clot strength (MA)and maximum platelet aggregation rate of TEG were compared between the two groups.The results of single detection and combined detection were compared.Results The values of R and K in the observation group were lower than those in the control group,and the values of MA,Angle and maximum platelet aggregation rate were higher than those in the control group,with statistical significances (P＜0.05).The sensitivity and specificity of TEG alone were 86.00% and 84.00% respectively.The sensitivity and specificity of platelet aggregation were 84.00% and 82.00% respectively.The sensitivity and specificity of combined detection were 98.00% and 96.00% respectively.The sensitivity and specificity of combined detection were higher than those of TEG and platelet aggregation function alone,and the differences were statistically significant (P＜0.017).Conclusion TEG combined with platelet aggregation function has significant value in detecting RSA.
2024 Vol. 31 (11): 109-111转116 [Abstract] ( 8 ) HTML (1 KB)  PDF (485 KB)  ( 14 )
112 Diagnostic value of serum procalcitonin in multi-drug resistant bacterial bloodstream infections
WEI Yun FENG Guimei WANG Shuguang YU Yongwen
Objective To evaluate the diagnostic value of serum procalcitonin (PCT) in multi-drug resistant bacterial bloodstream infections.Methods From January 1,2020 to December 31,2022,a total of 320 patients with multi-drug resistant bacteria bloodstream infection in Hunan Aerospace Hospital were selected as the research objects.Serum PCT of patients before the use of antibiotics was collected,and the correlation between multi-drug resistant bacterial bloodstream infection strains and serum PCT was analyzed.The accuracy and specificity of serum PCT level in distinguishing multi-drug resistant bacterial bloodstream infections were evaluated by drawing patient characteristic curve (ROC curve),and the cut off value was obtained by calculating the Joden index.Results The average level of serum PCT in Gram-negative bacteria infection group＞Gram-positive bacteria infection group＞fungal infection group.When the cut off value of serum PCT was 3.15 ng/ml,the sensitivity and specificity of diagnosis of multi-drug resistant bacterial bloodstream infections were 55.7%and 88.2%.Conclusion Serum PCT has important value and clinical significance in the diagnosis of multi-drug resistant bacterial bloodstream infections.
2024 Vol. 31 (11): 112-116 [Abstract] ( 8 ) HTML (1 KB)  PDF (522 KB)  ( 19 )
117 Diagnostic value of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 combined with urinary microscale albuminuria in pancreatitis complicated with acute kidney injury
XIAO Lihong LU Li SHI Wei
Objective To analyze the value of urine neutrophil gelatinase-associated lipocalin (NGAL),kidney injury molecule-1 (KIM-1)and urinary microscale albuminuria (MAU)detection in the early diagnosis of acute pancreatitis(AP)complicated with acute kidney injury (AKI).Methods A total of 120 AP patients admitted to Beijing Jishuitan Hospital Guizhou Hospital from July 2020 to July 2023 were selected as the research objects.According to whether AKI occurred within 7 d after admission,they were divided into AKI group and non-AKI group.Urine was collected on the day of admission and NGAL,KIM-1 and MAU levels were detected.The general data and urine NGAL,KIM-1 and MAU levels of the two groups were compared,and the correlation between NGAL,KIM-1 and MAU levels and acute physiology and chronic health evaluationⅡ(APACHEⅡ)scores were analyzed.Receiver operating characteristic curve(ROC)was used to evaluate the predictive value of NGAL,KIM-1 and MAU alone and in combination for AP complicated with AKI.Results There were no significant differences in age,sex,body mass index (BMI),history of diabetes,history of hypertension,time from onset to admission,and baseline serum creatinine level between two groups (P＞0.05).The APACHEⅡscore in AKI group was higher than that in non-AKI group,and the difference was statistically significant (P＜0.05).The levels of urine NGAL,KIM-1 and MAU in AKI group were higher than those in non-AKI group,with statistical significances (P＜0.05).Pearson correlation analysis showed that urine NGAL,KIM-1 and MAU levels were positively correlated with APACHEⅡscores(P＜0.05).ROC curve showed that the best cutoff values of urine NGAL,KIM-1 and MAU for predicting AP concurrent AKI were 158.50 ng/ml,3.23 ng/ml and 23.85 mg/L,respectively,the corresponding AUC were 0.872,0.853 and 0.841,and the AUC for combined diagnosis was 0.912.Conclusion Urine NGAL,KIM-1 and MAU detection have high predictive value for AP complicated with AKI,and can improve the early diagnosis efficiency.
2024 Vol. 31 (11): 117-120 [Abstract] ( 10 ) HTML (1 KB)  PDF (527 KB)  ( 2 )
121 Analysis on the status quo and influencing factors of family involvement behavior for the elderly lived in nursing homes
LIU Ying WANG Ting▲
Objective To investigate the level of family involvement behavior for the elderly lived in nursing homes and analyze its influencing factors.Methods From July 2021 to May 2022,a total of 128 family members of the elderly from 5 nursing home were randomly selected as the research objects.The general situation questionnaire and the family involvement behavior scale of institutionalized care were used.Results The items average score of family involvement behavior of institutionalized care was(3.36±0.74)points,which was at a medium level.The"involvement in life care"dimension scored lowest,followed by the"involvement in guidance and advice"and"involvement in decision support"dimension.The"involvement in economic support"dimension scored highest.Multiple linear stepwise regression analysis showed that the the elderly's living situation (β=-0.220,95%CI: -19.565 to -4.693, t=3.224, P=0.002) and marital status (β=0.296,95%CI:7.746-19.977,t=4.480,P＜0.001),family members'distance from the institution (β=-0.427,95%CI:-16.117 to-8.804,t=6.735, P＜0.001),the per capita monthly household income (β=0.212,95%CI: 2.279-10.276, t=3.103, P=0.002) and the relationship with the elderly(β=0.333,95%CI:6.831-15.340,t=5.150,P＜0.001)were the main influencing factors of family involvement behavior of institutionalized care(P＜0.05),explaining 44.10%of the total variation.Conclusion Family involvement behavior of institutionalized care still to be improved.For the elderly who are not living alone and have no partner,family members living far away,have low family per capita monthly income and are not children of the elderly,institutional managers should strengthen communication and guidance to promote family members'participating behavior.
2024 Vol. 31 (11): 121-124 [Abstract] ( 8 ) HTML (1 KB)  PDF (539 KB)  ( 6 )
125 Study on the correlation between job stressors,anxiety and depression,self-efficacy and coping style of emergency nursing staff after the opening of fever clinic
LIN Shuqing SHEN Xuejuan HONG Caixia
Objective To explore the correlation between job stressors and anxiety,depression,self-efficacy and coping style of emergency nurses after the establishment of fever clinic.Methods A total of 40 nurses working in Xiamen Haicang Hospital from December 2019 to March 2023 were selected as the research objects.Among them,20 nurses from Emergency Fever Clinic were selected as the experimental group,and 20 nurses from non-Emergency Department were selected as the control group.The nurses' job stressors scale,anxiety and depression scale,general self-efficacy scale and simple coping style scale were used to investigate the nurses of two groups after the establishment of fever clinic,and the correlation and influencing factors were analyzed according to the evaluation results.Results The total score of the stressor scale,the anxiety and depression scale,and the total score of the simple coping style scale of the experimental group were higher than those of the control group,and the differences were statistically significant(P＜0.05).The self-efficacy score of the experimental group was lower than that of the control group,and the difference was statistically significant(P＜0.05).Correlation analysis showed that the stressors of nurses from Emergency Department were positively correlated with anxiety (r=0.821,P=0.016)and depression (r=0.802,P=0.021)after the establishment of fever clinic,and negatively correlated with self-efficacy(r=-0.782,P=0.032),and simple coping style(r=-0.718,P=0.026).Conclusion Scientific theory and practice were used to guide nurses from Emergency Department to deal with such public health emergencies.Hospital managers and nurses themselves need to adopt different coping measures according to the pressure sources of nurses in different periods.Only the combination of the two can effectively solve the pressure of nurses from Emergency Department,so as to improve the quality of nursing.
2024 Vol. 31 (11): 125-128转134 [Abstract] ( 8 ) HTML (1 KB)  PDF (545 KB)  ( 16 )
129 Current situation and influencing factors of moisture -associated skin damage around the wound after abdominal puncture in cancer patients at the terminal stage
SONG Juan1 ZHU Yuelan2▲ ZHANG Lingling1
Objective To investigate the occurrence and influencing factors of moisture-associated skin damage (MASD)after abdominal puncture in cancer patients at the terminal stage.Methods From April 2020 to April 2023,convenience sampling was used to select 197 inpatients who underwent abdominal puncture catheter drainage in the Department of Oncology,the First People's Hospital of Kunshan as the research objects.The self-made general questionnaire and skin assessment form around the puncture were used to investigate the patients.Single factor and logistic regression analysis were used to analyze the influencing factors of exudation and skin damage at the puncture point.Results Among 197 patients with abdominal puncture,84 cases (42.64%)had continuous exudation at the puncture point.The results of univariate analysis showed that there were statistically significant differences in the incidence of puncture point exudation among patients with different body mass index,albumin value,random blood glucose and NRS 2002 score(P＜0.05).Logistic regression analysis showed that albumin (β=-0.060, OR=0.942,95%CI: 0.892-0.995) and random blood glucose (β=-0.761, OR=0.467,95%CI: 0.249-0.877) were influencing factors for wound exudation at the puncture point (P＜0.05).Forty-nine cases(24.87%)had secondary skin injury around the puncture,including 42 cases (21.32%)of MASD.The results of univariate analysis showed that there were statistically significant differences in the occurrence of skin injury around the wound among patients with different albumin values,indwelling time,random blood glucose and exudation (P＜0.05).Logistic regression analysis showed that random blood glucose(β=-1.752, OR=0.173,95%CI:0.074-0.408),catheter indwelling time (β=0.103,OR=1.109,95%CI:1.031-1.192)and with or without exudation (β=-2.805,OR=0.061,95%CI:0.022-0.163)were influencing risk factors for secondary skin injury around the puncture.Conclusion MASD after abdominal paracentesis in terminal stage of cancer patients is common,which affects the comfort of patients.Targeted measures should be taken to reduce its incidence or timely intervention.
2024 Vol. 31 (11): 129-134 [Abstract] ( 8 ) HTML (1 KB)  PDF (552 KB)  ( 8 )
135 Application effect of mixed teaching mode in microbiology laboratory teaching under the background of digital education strategy
ZHOU Yang1 ZHAO Xinyu2 YUAN Lin3 FU Xiaoxiao1 ZHANG Yexia1 LIU Yanyan4
Objective To explore the application effect of mixed teaching mode in microbiology laboratory teaching in higher vocational colleges under the background of digital education strategy.Methods A total of 138 students were selected as the research objects from two classes of medical laboratory major of grade 2021,Heze Medical Vocational College from September to October 2022.In the two classes,students studying at home due to the impact of epidemic control were selected as the online teaching group (n=37),students from Class 1 studying at school were selected as the offline teaching group(n=55)and students in Class 2 studying at school were selected as mixed teaching group (n=46).The online teaching group adopted the online information teaching method,the offline teaching group adopted the offline traditional teaching method,and the mixed teaching group adopted the mixed teaching method that integrates traditional teaching and information teaching.Through the comparison of three groups of students assessment results,teaching quality evaluation,teaching method satisfaction to evaluate the effectiveness of teaching experiments.Results There was no statistically significant difference in online seores among the three groups of students(P ＞0.05).The offline seores,daily seores,and comprehensive seores of mixed teaching were all higher than those of the online and offline teaching groups,the differences were statistically significant (P＜0.05).The evaluation of teaching quality of mixed teaching group was higher than that of online teaching group and offline teaching group,the difference was statistically significant(P＜0.05).Compared with the three groups,the difference of teaching satisfaction was statistically significant (P＜0.05),and the mixed teaching group had the highest satisfaction.Conclusion The use of mixed teaching method can improve the teaching effectiveness of microbiology testing,providing some reference basis for the teaching and talent cultivation of microbiology testing majors in higher vocational colleges.
2024 Vol. 31 (11): 135-139 [Abstract] ( 8 ) HTML (1 KB)  PDF (548 KB)  ( 1 )
140 Challenge of digestive endoscopy training and the exploration of innovative teaching mode
LIU Wei YUAN Xianglei
Training in digestive endoscopy is of significant importance for the diagnosis and treatment of gastrointestinal diseases,particularly in the prevention and management of early-stage gastrointestinal cancer.However,current training programs in digestive endoscopy face several challenges,including steep learning curves,limited practical opportunities,individual differences among trainees,lack of real-time feedback and guidance,insufficient training resources,and varying levels of training institutions.These factors influence the effectiveness of digestive endoscopy training to varying degrees.To address these challenges,this review analyzes innovative teaching models in digestive endoscopy,including blended learning,virtual reality and simulation training,artificial intelligence-assisted digestive endoscopy education,remote teaching and guidance,as well as the development of personalized learning and self-directed learning programs.The application of these innovative teaching models is expected to overcome the current challenges in digestive endoscopy training,enhance training effectiveness and quality,and promote innovative development in digestive endoscopy education,ultimately improving the early diagnosis and treatment of gastrointestinal diseases.
2024 Vol. 31 (11): 140-143 [Abstract] ( 10 ) HTML (1 KB)  PDF (502 KB)  ( 5 )
144 Lecture-based learning combined with WeChat platform based multiple disease teaching method in pediatric orthopedic surgery internship
XU Yanpeng ZHANG Qibo LI Min JIAN Qingyan YANG Xiaohong
Objective To explore the application effect of lecture-based learning(LBL)combined with multi disease teaching based on WeChat platform in clinical practice of pediatric orthopedic surgery.Methods Forty pediatric orthopedic interns from the Affiliated Hospital of Zunyi Medical University from January 2022 to September 2023 were selected and randomly divided into the control group (n=20)and the experimental group (n=20)by coin toss method.The control group received LBL teaching,while the experimental group received LBL+multi disease teaching based on WeChat platform.After 4 weeks of internship,the graduation assessment was carried out,and the satisfaction survey was carried out on the interns.Results The theoretical score of the control group was (83.90±2.49)points,the skill score was (87.90±2.29)points,the case score was(83.85±2.54)points,and the comprehensive score was(85.09±1.21)points.The theoretical score of the experimental group was (86.55±2.72)points,the skill score was (88.35±1.95)points,the case score was (85.85±3.12)points,and the comprehensive score was(86.88±1.97)points.The theoretical,medical and comprehensive scores of the experimental group were higher than those of the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in skill scores between the two groups (P＞0.05).The enthusiasm and recognition of the teaching mode of the experimental group were higher than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion The application of LBL+multi disease teaching based on WeChat platform in pediatric orthopedic surgery clinical practice has achieved good results and improved the quality of clinical practice.
2024 Vol. 31 (11): 144-147 [Abstract] ( 8 ) HTML (1 KB)  PDF (541 KB)  ( 5 )
148 Study on the nursing application of Dyclonine Hydrochloride Mucilage for indwelling catheterization in children with hypospadias
HUANG Hua XIE Qiulian ZHONG Yawen
Objective To explore the nursing effect of Dyclonine Hydrochloride Mucilage used for indwelling catheterization in children with hypospadias.Methods A total of 60 children with hypospadias who underwent urethroplasty in Ganzhou Maternal and Child Health Hospital from March 2021 to March 2023 were selected as the study objects.The children were divided into group A (20 cases),group B (20 cases)and group C (20 cases)by random number table method.In group A,aseptic paraffin oil was applied on the surface of the catheter and then catheterized with indwelling.In group B,Dyclonine Hydrochloride Mucilage 3-5 ml was fully applied on the surface of the catheter,and then indwelling the catheter.In group C,after the urethra was washed and disinfected before catheterization,3 ml of Dyclonine Hydrochloride Mucilage was injected into urethra,and then 3-5 ml of Dyclonine Hydrochloride Mucilage was fully applied to indwelling catheterization after catheterization.Ricker's sedation-agitation score during the recovery period,the occurrence of bladder irritation signs 2 h after returning to the ward,and the satisfaction of family members with indwelling catheterization were compared among the three groups.Results Ricker sedation-agitation score of group B and group C was lower than that of group A,and group C was lower than group B,the difference was statistically significant(P＜0.05).There was statistical significance in the incidence of bladder irritation among the three groups(P＜0.05).Pair-to-pair comparison showed that the incidence of bladder irritation in group A was higher than that in group C,with statistical significance(P＜0.017).There was no significant difference in satisfaction among three groups (P＞0.05).Conclusion Dyclonine Hydrochloride Mucilage used for indwelling catheterization in children with hypospadias can effectively reduce restlessness during recovery,reduce the risk of bladder irritation sign,and improve the satisfaction of family members with indwelling catheterization in children.
2024 Vol. 31 (11): 148- [Abstract] ( 8 ) HTML (1 KB)  PDF (654 KB)  ( 6 )
152 Application of checklist management supported by information technology in nursing safety of digestive endoscopy
LIU Huijuan1 XIE Minhua2 ZHU Meihua3▲ SHENG Chuanling4
Objective To explore the application effect of checklist management supported by information technology in nursing safety management of digestive endoscopy.Methods A total of 100 patients who underwent digestive endoscopy or treatment in Jiujiang University Affiliated Hospital from August 2020 to February 2022 were selected as the research objects,and they were divided into control group and observation group according to random number table method,with 50 cases in each group.The control group was given routine nursing management,and the observation group was given checklist management supported by information technology.The quality of nursing,the incidence of adverse events,patient satisfaction,and the pass rate of emergency drugs and equipment were compared between the two groups.Results The total incidence of nursing adverse events in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).The scores of instrument behavior,nursing attitude,nursing responsibility,professional skills,language communication and environmental facilities in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).The qualified rates of emergency medicine and equipment in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion The application of checklist management supported by information technology in nursing safety management of digestive endoscopy has significant effects,which can enhance the quality of nursing management,reduce nursing adverse events,and improve patients'satisfaction.
2024 Vol. 31 (11): 152-155 [Abstract] ( 7 ) HTML (1 KB)  PDF (652 KB)  ( 3 )
156 Study on drug education for patients with long-term prescription using self-made patient education tool
ZHENG Fen QIU Kaili YE Hui
Objective To explore the application value of self-made patient education tool in chronic disease patients with long-term use of prescription.Methods A total of 112 chronic patients with long-term prescription drug use admitted to the First Affiliated Hospital of Jiangxi Medical College from January to December 2022 were selected as the study objects,and they were divided into control group(56 cases)and experimental group(56 cases)according to random number table method.The control group received routine education,while the experimental group received the self-made education tool.Both groups were intervened for 1 month.The medication safety behavior,medication compliance and rational medication efficacy of the two groups were compared.Results Before the intervention,there were no statistically significant differences in the decision-making participation score,caring participation score,appeal participation score and total score of the medication safety behavior scale and the score of self-efficacy for appropriate medication use scale(SEAMS)of patients between the two groups(P＞0.05).After the intervention,the scores of decision-making participation,caring participation,appeal participation,total score and SEAMS score of the medication safety behavior scale of the two groups were higher than those before the intervention,and the scores of decision-making participation,caring participation,appeal participation,total score and SEAMS score of the medication safety behavior scale of the experimental group were higher than those of the control group,with statistically significant differences(P＜0.05).The medication compliance of experimental group was higher than that of control group,with statistically significant difference (P＜0.05).Conclusion The self-made patient education tool can improve the medication compliance of chronic disease patients with long-term use of prescription drugs,improve their medication safety behavior,and enhance the efficacy of rational drug use,which is worthy of promotion and application in medication education.
2024 Vol. 31 (11): 156-159 [Abstract] ( 8 ) HTML (1 KB)  PDF (683 KB)  ( 5 )
160 Effect of triple complementary intensive education on oral function exercise and quality of life in patients with head and neck cancer undergoing radiotherapy
LU Jing1 LIU Yan2 WU Xiaomei1▲
Objective To explore the effect of triple complementary intensive education on oral functional exercise and quality of life in patients with head and neck cancer undergoing radiotherapy.Methods A total of 70 patients with head and neck cancer who received radiation at Jiu Jiang NO.1 People's Hospital from February 2021 to August 2022 were selected as the research subjects,and they were divided into control group(35 cases)and observation group(35 cases)according to random number table method.The control group received routine nursing,while the observation group received triple complementary intensive education.The oral function exercise,quality of life and incidence of complications were compared between the two groups.Results After the intervention,the action evaluation and knowledge oral scores of the oral function exercise accuracy scale in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).After the intervention,the scores of various dimensions of physiological function,social function,physical function,and material life status of the generic quality of life inventory-74 (GQOL-74) scale in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The triple complementary intensive education intervention for patients with head and neck cancer can significantly improve the accuracy of oral functional exercise,improve the quality of life,and reduce the risk of related complications.
2024 Vol. 31 (11): 160-163 [Abstract] ( 9 ) HTML (1 KB)  PDF (652 KB)  ( 9 )
164 Effect of mindfulness therapy on stress response in patients undergoing modified electroconvulsive therapy for depression
LI Yumei1 ZHONG Guofeng2 FENG Xiaoling2
Objective To explore the effect of mindfulness therapy on stress response in depression patients treated with modified electroconvulsive therapy(MECT).Methods A total of 96 patients with depression treated with MECT in the Third People's Hospital of Maoming from July 2022 to April 2023 were selected as the research objects,and they were divided into study group and control group by random number table method,with 48 cases in each group.The control group received routine nursing before treatment,and the study group received routine nursing combined with mindfulness therapy before treatment.Heart rate (HR)and systolic blood pressure (SBP) were monitored on the day of admission,30 minutes before treatment and 2 hours after treatment.Self-rating anxiety scale (SAS) and Hamilton anxiety scale (HAMA) were used to measure the level of anxiety before intervention and 30 minutes before treatment.The stress response and improvement effect of anxiety state were compared between the two groups.Results Before the intervention,there were no significant differences in HR,SBP,SAS and HAMA scores between the two groups (P＞0.05).After intervention,HR and SBP 30 minutes before treatment and 2 hours after treatment,SAS and HAMA 30 minutes before treatment in the study group were lower than those in the control group,and the differences were statistically significant (P ＜0.05).Conclusion The application of mindfulness therapy can significantly improve the stress response and anxiety state of patients with depression undergoing MECT treatment,which is conducive to the smooth progress of MECT treatment and worthy of popularization and application.
2024 Vol. 31 (11): 164-167 [Abstract] ( 8 ) HTML (1 KB)  PDF (651 KB)  ( 1 )
168 Clinical effect of self -prepared Goucaopinggan Decoction on vertigo caused by vertebro-basilar artery insufficiency
QIU Bing HUANG Yuhuan HU Xiaohua
Objective To evaluate the clinical effect of self-prepared Goucaopinggan Decoction combined with nursing intervention in the treatment of vertigo caused by vertebro-basilar artery insufficiency.Methods A total of 80 patients with vertigo caused by vertebro-basilar artery insufficiency admitted to the Department of Internal Medicine of Fuzhou Hospital of Traditional Chinese Medicine from January 2022 to February 2023 were selected as the research objects.They were divided into control group(40 cases)and observation group(40 cases)by random number table method.The control group was given routine treatment and nursing intervention,while the observation group was given oral self-prepared Goucaopinggan Decoction on the basis of the control group.The general data of the two groups of patients were compared,and the differences in vertigo,quality of life,and psychological state before and after treatment in the two groups were compared.Results After treatment,the dizziness handicap inventory (DHI) score of the observation group was lower than that of the control group,the general quality of life inventory -74 (GQOL-74) score of the observation group after treatment was higher than that of the control group after treatment,with statistically significant differences(P＜0.05).The scores of self-rating depression scale (SDS)and self-rating anxiety scale (SAS)in the observation group after treatment were lower than those before treatment and in the control group after treatment,with statistically significant differences (P＜0.05).Conclusion The results of this study suggested that self-made hook grass and liver-leveling soup combined with nursing intervention could effectively improve the clinical symptoms of vertigo caused by vertebro-basilar artery insufficiency.
2024 Vol. 31 (11): 168-171 [Abstract] ( 8 ) HTML (1 KB)  PDF (653 KB)  ( 11 )
172 Effect of narrative nursing on anxiety and sleep in patients with coronary heart disease after percutaneous coronary intervention
WANG Minmin ZHANG Fang BO Jingjing CHEN Xiaoyang HOU Yongna WANG Xinxia▲
Objective To explore the effect of narrative nursing on anxiety and sleep in patients with coronary heart disease after percutaneous coronary intervention.Methods A total of 120 patients with coronary heart disease who received percutaneous coronary intervention treatment in the Department of Cardiology,the Affiliated Hospital of Binzhou Medical College from July 2020 to March 2021 were selected as the study objects,and divided into control group (60 cases) and experimental group (60 cases) according to random number table method.The control group received routine nursing interventions,while the experimental group received narrative nursing in addition to routine nursing interventions.Self-rating anxiety scale and Pittsburgh sleep quality index were used to evaluate the changes of anxiety and sleep quality before and after intervention.Results Before intervention,there was no significant difference in anxiety and sleep quality scores between the two groups (P＞0.05).After intervention,the anxiety scores and sleep quality scores of the experimental group were lower than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion Narrative nursing has a significant effect on improving anxiety and sleep quality of patients with coronary heart disease after percutaneous coronary intervention,and can promote patients'self-management and improve quality of life.
2024 Vol. 31 (11): 172-175 [Abstract] ( 8 ) HTML (1 KB)  PDF (682 KB)  ( 3 )
176 Study on the effect of high-quality nursing assisted by wrist health monitoring terminal on sleep disorder and hope level of patients with advanced lung cancer
YANG Ting1 FANG Haiyan1 ZOU Yanfang1 YANG Hua2▲
Objective To explore the effect of high-quality nursing assisted by wrist health monitoring terminal on sleep disorder and hope level of patients with advanced lung cancer.Methods A total of 350 patients with advanced lung cancer who were hospitalized in the Oncology Department of Jiangxi Cancer Hospital from June to December 2022 were selected as the study objects,and they were divided into the observation group and the control group with 175 patients in each group according to random number table method.The control group was treated with conventional nursing methods,and the observation group was treated with high-quality nursing intervention(wrist health monitoring terminal was introduced).Both groups completed the 4-week intervention.The sleep disorder,hope level,social support level and satisfaction were compared between the two groups.Results After 4 weeks of intervention,the observation group had lower scores of falling asleep time,overall sleep time and quality,daytime mood,nighttime awakening,physical quality,and sleepiness than the control group,and the differences were statistically significant (P＜0.05).After 4 weeks of intervention,the observation group had higher scores of positive attitudes towards reality and the future,attitudes towards taking positive actions,and attitudes towards maintaining intimate relationships with others than the control group,and the differences were statistically significant (P＜0.05).After 4 weeks of intervention,the social support levels of the two groups were higher than those in the same group before intervention,and the differences were statistically significant(P＜0.05).The objective support,subjective support,support utilization,and total score of the observation group were higher than those of the control group,and the differences were statistically significant (P＜0.05).The observation group had higher levels of intervention methods,service attitude,intervention effectiveness,professional skills,and satisfaction with nurse patient relationships compared to the control group after 4 weeks of intervention,and the differences were statistically significant (P＜0.05).Conclusion Wrist health monitoring terminal assisted high-quality nursing in patients with advanced lung cancer can help to improve patients'sleep quality and improve patients'hope level,worthy of popularization and application.
2024 Vol. 31 (11): 176-179转185 [Abstract] ( 8 ) HTML (1 KB)  PDF (1051 KB)  ( 5 )
180 Study on the inhibitory effect of TLR4/NF-κB/NLRP3 pathway on inflammatory response
WANG Jing BAI Shuancheng▲
Toll-like receptors (TLRs) are an important class of proteins involved in non-specific immunity,and they are one of the most important pattern recognition receptors expressed by innate immune cells.They can recognize conserved structure molecules from microorganisms,namely pathogen-associated molecular patterns (PAMAs),so as to activate the immune response.Nuclear factor kappa-B(NF-κB),which is expressed in virtually all types of cells and tissues,plays a key role in regulating the remarkable diversity of responses to external stimuli and is therefore a key factor in multiple physiological and pathological processes.NOD-like receptor protein 3(NLRP3),the NLRP3 inflammasome pathway,plays an important role in cerebral ischemia-reperfusion and pyroptosis.For example,NLRP3 is activated in microglia during cerebral ischemia-reperfusion injury and subsequently expressed in neurons and microvascular endothelial cells.The TLR/NF-κB/NLRP3 signaling pathway,which is activated by TLRs,transmitted by NF-κB and activated by NLRP3,plays a key role in the inflammatory response of various organs in the body.This paper discusses the role of various drugs in protecting major organs by inhibiting the inflammatory response of this pathway.
2024 Vol. 31 (11): 180-185 [Abstract] ( 11 ) HTML (1 KB)  PDF (584 KB)  ( 40 )
186 Research progress of integrated traditional Chinese and western medicine in the treatment of liver stagnation and spleen deficiency type hepatitis B liver fibrosis
ZHOU Zipeng1 LU Bingjiu2
Hepatitis B virus (HBV)is one of the most common causes of hepatic fibrosis (HF)and cirrhosis.Although the treatment of HF caused by HBV can achieve a good virological response,HF still exists and progresses continuously,so the use of anti-HF drugs is still questionable.In recent years,of traditional Chinese medicine has gained certain clinical effect in the treatment of HF based on its unique syndrome identification and treatment,and the treatment of chronic hepatitis B HF with integrated traditional Chinese and western medicine has become a hot spot.Studies have shown that HF of chronic hepatitis B with liver stagnation and spleen deficiency type occurs relatively early,mainly in the early stage of HF (S1)and liver pathological grades G1 and G2,which are important nodes for traditional Chinese medicine to control and reverse HF.This article reviews the research progress of traditional Chinese medicine compound combined with Entecavir,Adefovir Dipivoxil,interferon and Tenofovir in the treatment of chronic hepatitis B HF with liver stagnation and spleen deficiency in the past ten years,so as to provide more reference for clinical drug use and new drug research and development.
2024 Vol. 31 (11): 186-190 [Abstract] ( 8 ) HTML (1 KB)  PDF (608 KB)  ( 9 )
191 Research progress in cardiac injury associated with cerebral amyloid angiopathy
LYU Wencai OUYANG Sheng▲ LI Jiangjiao ZHANG Zhijiang
Cerebral amyloid angiopathy is a prevalent disease in the world,more common in elderly patients with Alzheimer's disease,and the end result is multiple microbleeding foci in the brain.It is characterized by the deposition of amyloid-β in the cerebral cortex and leptomeningeal blood vessel wall,which may induce the chronic inflammatory state of the brain and damage the integrity of the blood brain barrier by activating astrocytes,microglia,and pro-inflammatory substances.Cerebral amyloid angiopathy is the main cause of cognitive changes and intracerebral hemorrhage in the elderly,and patients are often associated with cardiac damage.Cardiac damage caused by cerebral amyloid angiopathy is a new area of research that requires in-depth analysis to provide therapeutic and preventive targets.
2024 Vol. 31 (11): 191-194 [Abstract] ( 9 ) HTML (1 KB)  PDF (549 KB)  ( 2 )
195 Research progress on the application of silver nanoparticles synthesized from plant extracts in the treatment of dental caries
JIAO Lu1 WANG Yuewu2
Oral diseases such as dental caries are the most common non-communicable diseases in the world.These diseases can progress to systematic diseases when left untreated.Caries prevention has traditionally relied on oral hygiene and diet control,among other preventive measures.Among inorganic nanomaterials,silver nanoparticles (AgNPs) have shown promising outcomes in dental therapy,due to their unique physicochemical properties and enhanced anti-bacterial activities.Sealing materials are important factors that affect the anticarious effect.The most common use of sealing materials includes resin-based sealants and glass ionomer sealants.As such,AgNPs may provide newer strategies for treatment and prevention of dental infections.However,many drawbacks around the chemical synthesis of nanomaterials,which are not limited to the use of toxic reducing agents,have been raised.This has inspired researchers to develop the green synthesis route,which uses natural products as reducing agents.The biogenic AgNPs were reported to be biocompatible and environmentally friendly when compared to the chemically-synthesized AgNPs.As such,plant-synthesized AgNPs can be used as antimicrobial,antifouling,and remineralizing agents for the treatment of dental caries and oral diseases.
2024 Vol. 31 (11): 195-198 [Abstract] ( 9 ) HTML (1 KB)  PDF (687 KB)  ( 21 )
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