Objective To explore the effect of different oxygen therapy on chronic obstructive pulmonary disease(COPD) complicated with pulmonary heart disease.Methods A total of 90 patients with COPD complicated with pulmonary heart disease admitted to Yichun People′s Hospital from January 2019 to June 2020 were selected as the research subjects and divided into group A (30 cases), group B (30 cases) and group C (30 cases) according to random drawing method.Group A was treated with Venturi mask ways of oxygen inhalation, group B was treated with continuous positive airway pressure (CPAP), group C was treated with humidified high flow nasal cannual (HHFNC).The breathing rate, heart rate and SpO2, PaO2, PaCO2, pH value of each time after oxygen therapy in three groups were compared, and the hospitalization time, re-intubation rate and patient comfort degree in three groups were analyzed.Results The heart rates of 2, 6, 12, 24, 48 hours after oxygen therapy in group B were higher than those in group A and group C, the differences were statistically significant (P＜0.05).The breathing rates of 2, 6, 12, 24, 48 hours after oxygen therapy in group B were higher than those in group A and group C, the differences were statistically significant (P＜0.05).The PaO2 of 12 hours after oxygen therapy in group B was higher than that in group A and group C, the differences were statistically significant (P＜0.05).The PaO2 of 24, 48 hours after oxygen therapy in group A was lower than that in group B and group C, the differences were statistically significant (P＜0.05).The PaCO2 of 12, 24, 48 hours after oxygen therapy in group A was higher than that in group B, the PaCO2 of 48 hours after oxygen therapy in group A was higher than that in group C, the differences were statistically significant (P＜0.05).There was no significant difference in SpO2 among the three groups (P＞0.05).There was no significant difference in the pH value among the three groups (P＞0.05).The hospitalization time of group A was longer than that of group B and group C, the differences were statistically significant (P＜0.05).The re-intubation rate of group A was higher than that of group B and group C, the differences were statistically significant (P＜0.05).The patient comfort degree of group C was better than that of group A and group B, the differences were statistically significant (P＜0.05).Conclusion HHFNC could effectively alleviate the clinical symptoms of patients with COPD complicated with pulmonary heart disease, improve the ventilation status, reduce the re-intubation rate, improve the comfort degree of patients and shorten the length of hospitalization time.HHFNC is more popular with patients, it is worthy of promotion and application.

Objective To explore the relationship between acute ischemic stroke with intracranial/extracranial atherosclerotic stenosis and alkaline phosphatase (ALP).Methods Patients with acute schemic stroke admitted to the Department of Neurology, the Second Affiliated Hospital of Anhui Medical University from January to June 2020 were enrolled retrospectively.According to the head and neck computed tomography angiography (CTA) examination, those with a stenosis rate of intracranial/extracranial arteries ≥50% were classified as the stenosis group (intracranial/extracranial atherosclerotic stenosis), and those with a stenosis rate ＜50% or without vascular stenosis were classified as the control group (non-cerebral atherosclerosis stenosis).The demographic data and baseline clinical data were collected, and the correlation between different alkaline phosphatase levels and the incidence of intracranial/extracranial atherosclerotic stenosis was analyzed.The multivariate Logistic regression analysis was used to analyze the influencing factors of intracranial/extracranial atherosclerosis in patients with acute ischemic stroke.Results A total of 163 patients were enrolled, including 72 cases in the stenosis group, 91 cases in the control group.The age, incidence of diabetes,ALP, fasting blood glucose, triglycerides, and low-density lipoprotein cholesterol levels of the stenosis group were higher than those of the control group, the differences were statistically significant (P＜0.05).With the increase of serum ALP level, the incidence of intracranial/extracranial atherosclerotic stenosis gradually increased (P＜0.05).Multivariate Logistic regression analysis indicated that serum ALP level was one of the risk factors for intracranial/extracranial atherosclerotic stenosis in ischemic stroke patients (OR=1.024, 95%CI: 1.009-1.039, P=0.002).Conclusion The serum ALP level is associated with intracranial/extracranial atherosclerotic stenosis in patients with ischemic stroke, and ALP can reflect the degree of intracranial/extracranial atherosclerotic stenosis to some extent.

Objective To investigate the correlation between Aspirin and sarcopenia in patients with type 2 diabetes.Methods A cross-sectional survey was conducted in 939 patients with type 2 diabetes who were admitted to the First Affiliated Hospital of Chongqing Medical University from June 2013 to December 2015.Patients were divided into Aspirin group (504 cases) and non-Aspirin group (435 cases) according to whether they took aspirin or not.The covariates of the patients were matched by the propensity score matching method, and the correlation between Aspirin and sarcopenia was evaluated by univariate Logistic regression.Results Among the 939 patients with type 2 diabetes, 184 patients (19.6%) had sarcopenia.Propensity score matching method was further used to match the covariates of sarcopenia(age, hemoglobin, body mass index, serum uric acid, high-density lipoprotein cholesterol, triglyceride, neutrophil percentage, diabetic foot, diabetic neuropathy), after matching, Aspirin group (503 cases) and non-Aspirin group (307cases).Before and after propensity score matching, the prevalence rate of sarcopenia in Aspirin group was lower than that in non-Aspirin group, and the difference was statistically significant (P＜0.05).Conclusion Aspirin medication is associated with sarcopenia in patients with type 2 diabetes, which indicate that Aspirin may reduce the risk of sarcopenia.Further validation is required by clinical studies.

 

 

Curcumin is a non-steroidal anti-inflammatory drug that has a wide range of preventive and therapeutic effects on a variety of diseases and can effectively remove free radicals.Its antioxidant activity and anti-inflammatory effects have attracted wide attention.Curcumin can participate in the development of osteoarthritis by activating or inhibiting multiple signaling pathways, inhibiting chondrocyte apoptosis and degradation of chondrocyte extracellular matrix, reducing the production of various inflammatory factors, promoting chondrocyte autophagy and inhibition proliferation of synovial cells and release of inflammatory factors.However, the signaling pathway of curcumin in the treatment of osteoarthritis has not been fully elucidated.Based on this, this paper reviews the molecular mechanisms of curcumin in the treatment of osteoarthritis at home and abroad in recent years.

With the increasing incidence of tumors year by year, the tumors themselves and tumor treatment may cause various adverse reactions, which seriously affect patients′ treatment tolerance and compliance, and thus influencing the quality of life.Therefore, the rehabilitation of malignant tumors has been paid attention by clinicians, and the diagnosis and treatment of tumors usually requires multi-disciplinary cooperation.In recent years, it has been gradually found that comprehensive treatment combined with traditional Chinese medicine (TCM) can not only effectively control tumors, but also improve the quality of life of patients, which is of great significance for promoting body rehabilitation.This paper provides a new idea for the thinking on the multi-disciplinary comprehensive treatment combined with TCM in the rehabilitation of malignant tumors, as well as the clinical treatment of malignant tumors and tumor rehabilitation for contemporary clinicians.

Cervical cancer is a malignant tumor that originates in the cervix.It is one of the most common malignant tumors that threaten women′s health in the world.Early symptoms are often not obvious.Despite using of advanced screening methods and preventive vaccines，the morbidity and mortality are still high in developing countries, so it is necessary to find new more effective molecular markers to further assist the diagnosis, treatment and prognosis cervical cancer.The miRNA-34 family plays an important role in the process of tumor cell proliferation, cycle regulation, apoptosis and aging, and it′s also a hotspot in cancer molecular targeted therapy.This article summarizes the molecular mechanism of miRNA-34 family in malignant tumors, and focuses on the role and research progress of miRNA-34 in cervical cancer.

 Helicobacter pylori (Hp) infection plays an important role in the occurrence and development of gastric polyps.Different types of gastric polyps and Hp infections in different parts have their own characteristics and differences.Due to the widespread use of proton pump inhibitors (PPI) and the excessive eradication of Hp, the pathological type of patients with gastric polyps is changing, and fundic gland polyps have gradually surpassed hyperplastic polyps as the main pathological type.This article aims to improve the detection rate and accuracy of endoscopic diagnosis and reduce the misdiagnosis rate of endoscopic diagnosis through comprehensive domestic and foreign studies on the various pathological types of gastric polyps, the characteristics of gastric polyps in different parts and the differences in Hp infection rates, thereby improving the detection rate and accuracy of endoscopic diagnosis, reducing the rate of misdiagnosis and missed diagnosis of endoscopy, especially extremely important to the screening rate of early cancer and the prevention and control of cancer.

On the basis of analyzing that external auditory meatal cholesteatoma is a benign tumor, which is aggressive, destructive, can cause hearing loss, and even cause serious intracranial and extracranial complications that threaten life and affect the quality of life of patients, this article discusses the development of CT imaging diagnosis of external auditory canal cholesteatoma and its important role in the diagnosis of external auditory canal cholesteatoma.By introducing the method of CT examination of external auditory canal cholesteatoma, analyzing the CT value in the diagnosis of external canal cholesteatoma in children and the external auditory canal cholesteatoma and other diseases of the external auditory canal CT identification method, it is concluded that CT examination can discover the external auditory canal cholesteatoma early pathological changes, realize the external auditory canal cholesteatoma accurate diagnosis,improve external auditory canal cholesteatoma diagnostic rate, which has high clinical value.At the same time, It should be noted that CT in clincal application is still unable to comprehensively diagnose external auditory canal cholesteatoma of various causes, so magnetic resonance imaging （MRI） and other imaging technology are needed to diagnose external auditory canal cholesteatoma better and improve the quality of treatment.

With the development of perinatal technology, the survival rate of premature infants increased significantly,but the incidence of brain injury in premature infants did not decrease accordingly.Both Burdjalov score and middle cerebral artery blood flow can be utilized in bedside monitoring of premature infants, which is the main examination means to monitor the brain development maturity and brain injury of premature infants.Through the study of brain bioelectricity and circulation, it is found that there is a correlation between electroencephalogram activity and cerebral blood flow, but the correlation between the two in premature infants is lack of large sample research and elaboration.Therefore, by reviewing and summarizing the published relevant literature, this paper studies and discusses the parameters, correlation physiological basis of Burdjalov score and middle cerebral artery blood flow, as well as the correlation and limitations of Burdjalov score and cerebral middle artery blood flow in normal preterm infants and premature infants with brain injury.The aim is to evaluate the brain function development and brain injury of premature infants more comprehensively, to provide new basis for prognosis intervention, and to promote the healthy growth of premature infants.

Objective To explore the effect of active circulatory breathing exercise on the course of disease during bronchodilation therapy.Methods From January to May in 2020, a total of 80 patients with bronchiectasis and infection who were admitted to Xinyu Xingang Central Hospital of Jiangxi Province were selected as the research objects.According to different treatment methods, they were divided into the control group and the study group, with 40 cases in each group.The control group received antibiotic treatment, and the study group carried out active circulatory and breathing exercise training on the basis of antibiotic treatment.The hospitalization status, 6-minute walk test results,forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow rate, respiratory rate and other pulmonary function indexes of patients were compared between the two groups.Results The duration of antibiotic use and hospital stay in the study group were shorter than those in the control group, and the cost of hospital stay was lower than that in the control group, with statistically significant differences (P＜0.05).There was no significant difference in 6-minute walk test result between the two groups before treatment (P＞0.05); the 6-minute walk test results of two groups after treatment were longer than those before treatment, with statistically significant differences (P＜0.05);the 6-minute walk test result after treatment in the study group was longer than that in the control group, with statistically significant differences (P＜0.05).There were no statistically significant differences between the two groups in lung function indicators such as FVC, FEV1, expiratory peak flow rate, and respiratory frequency before treatment (P＞0.05);after treatment, the FVC and FEV1 of patients of the two groups were higher than those before treatment, the peak expiratory flow rate was faster than that before treatment, and the respiratory frequency was lower than that before treatment, with statistically significant differences (P＜0.05);after treatment, FVC and FEV1 of the the study group were higher than those in the control group, the peak expiratory flow rate was faster than that in the control group, and the respiratory frequency was lower than that in the control group, with statistically significant differences (P ＜0.05).Conclusion Active circulatory respiratory exercise training can effectively shorten the course of patients with bronchiectasis, simultaneously improve lung function, exercise endurance and reduce the cost of hospitalization.

Objective To investigate the value of Fibroscan and aspartate aminotransferase (AST) to platelet ratio index(APRI) in the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB) complicated with fatty liver.Methods CHB patients with fatty liver from January to December 2017 in Yangjiang Public Health Hospital were selected,and 46 cases were selected for retrospective analysis.The patients were all performed Fibroscan and APRI detection.The patients were followed up for 2 years to observe the fibrosis of the patients at this stage and to monitor their condition.Results There was no significant difference between Fibroscan and APRI in the detection rate of different degrees of fibrosis and pathological detection (P＞0.05).After 2 years of treatment, the APRI, Fibroscan, AST indexes were lower than the initial value, the differences were statistically significant (P＜0.05).While there was no significant difference in the blood platelet indexes between after 2 years of treatment and initial value (P＞0.05).With the aggravation of liver fibrosis, the detection of APRI and Fibroscan increased.Conclusion The combination of Fibroscan and APRI in CHB patients with fatty liver can comprehensively analyze the changes in liver fibrosis, and dynamically monitor the disease, which has a positive significance for disease monitoring and can improve the quality of comprehensive interventions, is conducive to the treatment of later disease.

Objective To investigate the value of Fibroscan and aspartate aminotransferase (AST) to platelet ratio index(APRI) in the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB) complicated with fatty liver.Methods CHB patients with fatty liver from January to December 2017 in Yangjiang Public Health Hospital were selected,and 46 cases were selected for retrospective analysis.The patients were all performed Fibroscan and APRI detection.The patients were followed up for 2 years to observe the fibrosis of the patients at this stage and to monitor their condition.Results There was no significant difference between Fibroscan and APRI in the detection rate of different degrees of fibrosis and pathological detection (P＞0.05).After 2 years of treatment, the APRI, Fibroscan, AST indexes were lower than the initial value, the differences were statistically significant (P＜0.05).While there was no significant difference in the blood platelet indexes between after 2 years of treatment and initial value (P＞0.05).With the aggravation of liver fibrosis, the detection of APRI and Fibroscan increased.Conclusion The combination of Fibroscan and APRI in CHB patients with fatty liver can comprehensively analyze the changes in liver fibrosis, and dynamically monitor the disease, which has a positive significance for disease monitoring and can improve the quality of comprehensive interventions, is conducive to the treatment of later disease.

Objective To explore the clinical effect of Esmolol combined with low-dose Amiodarone in the treatment of patients with coronary heart disease and arrhythmi.Methods From August 2017 to August 2019, a total of 60 cases of coronary heart disease with arrhythmia patients from the Fifth People′s Hospital of Shenyang were chosen as the research objects, they were divided into observation group (32 cases) and control group (28 cases) according to different treatment methods.The control group was treated with Amiodarone alone, on this basis, the observation group was treated with Esmolol, the cardiac function indexes, electrocardiogram indexes and treatment effect were compared between two groups.Results Before treatment, there was no statistically significant difference in cardiac function between the groups(P＞0.05); after treatment, the left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) in two groups were lower than those before treatment, left ventricular ejection fraction (LVEF) was higher than that before treatment，the differences were statistically significant (P＜0.05); after treatment, the LVEDV and LVESV in the observation group were lower than those in control group, and LVEF was higher than that in control group, the differences were statistically significant (P＜0.05).Before treatment, electrocardiogram indexes of the two groups were compared, the differences were not statistically significant (P＞0.05); after treatment, heart rate and Q-T interval values of two groups were lower than those before treatment, the differences were statistically significant (P＜0.05); after treatment, heart rate and Q-T interval of observation group were lower than those in control group, the differences were statistically significant (P＜0.05).The totla therapeutic effect of observation group was higher than that of control group, the difference was statistically significant (P＜0.05).Conclusion Esmolol combined with low-dose Amiodarone in the treatment of coronary heart disease complicated with arrhythmia can play a synergistic effect, effectively improve the patient′s heart function, and has a definite effect.It is an ideal medication plan.

Objective To explore the application effect of washing red blood cells in the treatment of patients with repeated red blood cell transfusion.Methods A total of 77 patients who underwent repeated blood transfusions at Fengcheng People′s Hospital in Jiangxi Province from January 2019 to January 2020 were selected as the research objects and divided into the control group (39 cases) and the observation group (38 cases) using random number table method.The control group was treated with leukocyte-removed red blood cell infusion, and the observation group was treated with washed red blood cell suspension infusion.The blood indicators, treatment effect and adverse reactions of the two groups were compared.Results There were no significant differences in the levels of hemoglobin (Hb), red blood cells (RBC), white blood cells (WBC) and platelets (PLT) between the two groups before treatment (P＞0.05).The levels of Hb and RBC in the observation group after treatment were higher than those of the control group, and the differences were statistically significant (P＜0.05).After treatment, there were no significant differences in WBC and PLT between the two groups (P＞0.05).The total effective rate of the observation group (97.37%) was higher than that of the control group (79.49%), and the difference was statistically significant (P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups during treatment (P＞0.05).Conclusion Infusion of washed red blood cells in patients with repeated blood transfusions can effectively increase the levels of hemoglobin and red blood cells in the patients′ body, thereby improving the therapeutic effect, and the safety is good.

Objective To explore the clinical efficacy of Liraglutide in the treatment on type 2 diabetes mellitus, and its effect on glycosylated hemoglobin (HbA1c), blood glucose, body weight and triglyceride (TG).Methods A total of 100 patients with type 2 diabetes admitted to the First Department of Internal Medicine in Dongguan Fenggang Hospital from January 2019 to January 2020 were selected for the prospective study.They were divided into control group (50 cases)and observation group (50 cases) according to the random number table method.The control group was treated with Metformin, while the observation group was treated with Liraglutide.HbA1c, blood glucose, Body mass index (BMI) and TG were compared between the two groups before and after treatment.Results There were no significant differences in fasting blood glucose (FPG) and 2 h postprandial blood glucose (2 h PG) between the two groups before treatment (P＞0.05).The FPG and 2 h PG of two groups after treatment were lower than those before treatment, and the FPG and 2 h PG of observation group after treatment were lower than those of control group, the differences were statistically significant (P＜0.05).There were no significant differences in HbAlc, BMI and TG between the two groups before treatment(P＞0.05).HbAlc, BMI and TG of two groups after treatment were lower than those before treatment, while HbA1c, BMI and TG of observation group after treatment were lower than those of control group, the differences were statistically significant (P＜0.05).Conclusion Liraglutide treatment has a remarkable clinical effect on type 2 diabetes mellitus,which is worthy of reference and promotion in clinical practice.It can also effectively reduce the indicators of HbAlc,blood glucose, BMI and TG.

Objective To explore the correlation between serum homocysteine (Hcy) level and adverse pregnancy outcome in patients with gestational diabetes mellitus (GDM).Methods A total of 65 GDM patients who visited Benxi Central Hospital from January 2018 to January 2020 were selected as study subjects.Patients were followed up until delivery, and divided into adverse pregnancy outcome group (n=13) and good pregnancy outcome group (n=52) according to pregnancy outcomes.Compare the laboratory indexes of the two groups. Pearson correlation was used to analyze the correlation between serum glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) and Hcy in GDM patients.Logistic regression was used to analyze the relationship between serum HbA1c, Hcy, FBG and adverse pregnancy outcomes.Results Adverse pregnancy outcomes occurred in 13 patients.The levels of serum HbA1c, FBG and Hcy in the adverse pregnancy outcome group were higher than those in the good pregnancy outcome group, the differences were statistically significant (P＜0.05). Pearson correlation analysis showed that serum HbA1c, FBG and Hcy levels in GDM patients were positively correlated (r＞0, P＜0.01). Logistic regression analysis showed that high expression of serum HbA1c (β=1.059, OR=2.883, 95%CI=1.255-6.626), Hcy (β=0.896, OR=2.451, 95%CI=1.491-4.028), FBG (β=0.437,OR=1.548, 95%CI=1.122-2.136) in patients with GDM were risk factors for adverse pregnancy outcomes (P＜0.05).Conclusion HbA1c level of GDM patients is closely related to FBG level and Hcy level.The high expression of serum Hcy, FBG and HbA1c has a certain correlation with the incidence of adverse pregnancy outcomes in GDM patients.In clinics, the expression of serum Hcy, FBG and HbA1c levels in GDM patients can be used to predict the risk of adverse pregnancy outcomes and guide risk assessment and therapeutic intervention.

Objective To explore the efficacy and safety of Acarbose and Insulin in the treatment of elderly type 2 diabetes.Methods A total of 76 patients with type 2 diabetes who visited the Department of Outpatient in Zibo Zhoucun District Center for Disease Control and Prevention from January 2019 to June 2020 were selected as the research subjects.According to the random number table method, they were divided into conventional group (38 cases) and combined group (38 cases).The conventional group was treated with Insulin, and the combined group was treated with Acarbose on the basis of the routine group.The blood glucose, insulin function and the total incidence of adverse reactions were compared between the two groups before and after treatment.Results There was no significant difference in glycated hemoglobin (HbA1c), fasting blood-glucose (FBG) and 2 h postprandial blood glucose (2 h PG) between the two groups before treatment (P＞0.05).HbA1c, FBG, and 2 h PG in the combination group after treatment were lower than those in the conventional group, the differences were statistically significant (P＜0.05).There were no significant differences in the islet B cell function index (HOMA-B) and insulin resistance index (HOMA-IR) between the two groups before treatment (P＞0.05).HOMA-B level after treatment in the combination group was higher than that of the conventional group, and HOMA-IR was lower than that of the conventional group, the differences were statistically significant (P＜0.05).The total incidence of adverse reaction in the combination group was lower than that in the conventional group, and the difference was statistically significant (P＜0.05).Conclusion Acarbose combined with Insulin can better regulate the blood glucose level of patients, effectively improve the insulin function of patients, and has a higher drug safety, which is worthy of extensive promotion and application.

Objective To explore the effect of warming carbon dioxide pneumoperitoneum on the changes of body temperature and blood loss in patients undergoing laparoscopic hepatolobectomy.Methods A total of 30 patients with laparoscopic hepatectomy admitted to Jiangxi Provincial People′s Hospital from October 2018 to may 2019 were selected as subjects and divided into experimental group and control group by the random number table method, with 15 cases in each group.Patients in the experimental group were treated with heated carbon dioxide pneumoperitoneum and the control group were treated with normal temperature carbon dioxide pneumoperitoneum.The vital signs and complications of the two groups were compared.Results There was no significant difference in body temperature between the two groups before pneumoperitoneum, three hours after pneumoperitoneum, half an hour after operation and one hour after operation (P＞0.05).The body temperature of the experimental group at half an hour after pneumoperitoneum, one hour after pneumoperitoneum, two hours after pneumoperitoneum, five minutes after deflation and one hour after operation in the experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The amount of intraoperative bleeding in the experimental group was less than that in the control group,and the difference was statistically significant (P＜0.05).The total incidence of complications in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The use of warming carbon dioxide pneumoperitoneum for patients undergoing laparoscopic hepatectomy can help patients improve their body temperature, reduce intraoperative bleeding and adverse reactions, and has certain promotion value.

Objective To investigate the clinical effect of laparoscopic transumbilical single-hole appendectomy in the treatment of perforated appendicitis in children and its effect on pain score (VAS).Methods Retrospectively selected 225 children with perforated appendicitis treated in Sanming First Hospital Affiliated to Fujian Medical University from October 2016 to June 2020 as the research objects, and divided them into control group (105 cases) and observation group (120 cases) according to different treatment methods.The control group was treated with traditional open surgery,and the observation group was treated with laparoscopic transumbilical single-hole appendectomy.The operative indicators, and total peripheral white blood cell (WBC), C-reactive protein (CRP), visual analogue scale (VAS) scores before and 3, 6 days after surgery, the incidence of complications were compared between the two groups.Results The operation time and hospitalization time of the observation group were shorter than those of the control group, and the amount of intraoperative blood loss was less than that of the control group, the differences were statistically significant(P＜0.05).There were no significant differences in preoperative WBC, CRP and VAS scores between the two groups (P＞0.05).The WBC, CRP and VAS at 3 and 6 d after surgery in both groups were lower than those before surgery, and the observation group was lower than that in the control group, the differences were statistically significant (P＜0.05).The total incidence of postoperative complications in observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Laparoscopic transumbilical single port appendectomy has high application value in the treatment of perforated appendicitis in children, which can shorten the operation time of patients, reduce the amount of bleeding, shorten the hospitalization time, improve the inflammatory reaction and reduce the pain of patients, which is worthy of promotion.

Objective To investigate the effect of low small incision resection in the treatment of thyroid tumor.Methods A total of 120 patients with thyroid tumor admitted to Panjin Central Hospital from January 2018 to June 2019 were selected as the research objects, and they were divided into two groups according to the random number table method, with 60 cases in each group.The patients in the control group were treated with conventional surgery, while those in the study group were treated with low small incision resection.The operation, pain, cosmetic incision and incidence of complications between the two groups were compared.Results The operation time, surgical incision and hospitalization time of patients in the study group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).The intraoperative blood loss in the study group was less than that in the control group,and the difference was statistically significant (P＜0.05).The pain visual analogue scale (VAS) scores of the study group at 6 and 24 h after surgery were lower than those of the control group, and the differences were statistically significant(P＜0.05).The incision cosmetic score in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The total incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Low small incision resection has a significant effect in the treatment of thyroid tumor.It does not affect the postoperative cosmetic effect, reduces the incidence of complications, shortens the postoperative recovery time, and is safer.It should be widely used in clinical practice.

Objective To compare the effect of thoracoscopic-assisted minimal-incision surgery and conventional thoracotomy in the treatment of multiple rib fractures complicated with lung laceration.Methods A total of 61 patients with multiple rib fractures complicated with lung laceration admitted to the Fourth People′s Hospital of Sichuan Province from October 2007 to May 2019 were retrospectively selected as the research subjects, they were divided into the thoracoscopic group (35 cases) and the traditional thoracotomy group (26 cases) according to surgical methods.In the thoracoscopic group, internal fixation of rib fracture with small incision and repair of lung laceration were performed assisted by thoracoscopy, while in the traditional thoracotomy group, internal fixation of rib fracture and repair of lung laceration were performed with thoracotomy.The operative time, postoperative ventilator assistance time, intensive care unit (ICU) monitoring time, thoracic catheter placement time, hospital stay, intraoperative blood loss, intraoperative fracture number, visual analog scale (VAS) score of pain on the first day after surgery, excellent and good rate of surgical effect and incidence of complications in the two groups were compared.Results The operative time, postoperative ventilator assistance time, ICU monitoring time, thoracic catheter placement time and hospitalization time in the thoracoscopic surgery group were all shorter than those in the traditional thoracotomy group, the differences were statistically significant (P＜0.05).The intraoperative blood loss in the thoracoscopic group was less than that in the traditional thoracotomy group, and the difference was statistically significant (P＜0.05).The VAS score of the thoracoscopic group on the first day after surgery was lower than that of the traditional thoracotomy group, and the difference was statistically significant (P＜0.05).The excellent and good rate of surgery in the thoracoscopic group was higher than that in the traditional thoracotomy group, and the difference was statistically significant (P＜0.05).There were no significant differences in the number of intraoperative internal fixation fractures and the total incidence of complications between two groups (P＞0.05).Conclusions Thoracoscopic surgery with small incisions is better than the conventional thoracotomy surgery in the treatment of multiple rib fractures and pulmonary laceration, for the former one has demonstrated the merits of less trauma, less postoperative pain, recovery in a shorter period and better postoperative effect.Therefore,thoracoscopic surgery with small incisions could be used more in clinical practice.

Objective To investigate the effect of video-assisted thoracoscopy in the treatment of mediastinal tumors.Methods A total of 82 patients with mediastinal tumor treated in Tiemei General Hospital of Liaoning Health Industry Group from June 2018 to January 2020 were selected as the research subjects and divided into the control group (41 cases) and the experimental group (41 cases) according to random number table method.The control group was treated with conventional thoracotomy, and the experimental group was treated with video-assisted thoracoscopy.The surgical indicators, length of stay, pain, bad mood and total incidence of complications were compared between the two groups.Results The postoperative drainage volume and intraoperative blood loss in the experimental group were less than those in the control group, the operative time and hospitalization time in the experimental group were shorter than those in the control group, the differences were statistically significant (P＜0.05).The scores of self-rating anxiety scale (SAS),self-rating depression scale (SDS) and visual analogue scale (VAS) in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05).The total incidence of postoperative complications in experimental group was lower than that in the control group, and the difference was statistically significant(P＜0.05).Conclusion Video-assisted thoracoscopy can reduce intraoperative blood loss, shorten operation time and hospitalization time, improve bad mood, improve compliance, and reduce postoperative complication rate in patients with mediastinal tumor.The therapeutic effect is clear and can be widely used in clinical practice.

Objective To investigate the effect of laparoscopic cholecystectomy (LC) on postoperative recovery and quality of life in patients with gallstones.Methods A total of 72 patients with gallstones admitted to the First Hospital of Qinhuangdao from March 2018 to March 2020 were selected and divided into two groups according to the random number table method, with 36 cases in each group.Patients in the control group were treated with small incision cholecystectomy, and patients in the experimental group were treated with LC.The postoperative recovery indexes, quality of life and incidence of complications of the two groups were compared.Results The postoperative recovery indexes (postoperative exhaust time, bowel sound recovery time, time to get out of bed for the first time, hospitalization time) in the experimental group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).The scores of postoperative psychological function,social function,material life,and physical function of the experimental group were higher than those of the control group, and the differences were statistically significant (P＜0.05).The total incidence of postoperative complications in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion LC can reduce the incidence of postoperative complications of patients with gallstones, which is more beneficial to the early recovery and the improvement of quality of life.

Objective To investigate the effect of radical incision and drainage in the treatment of perianal abscess and the prognosis and rehabilitation.Methods From January 2017 to June 2020, 90 patients with perianal abscess admitted to the First People′s Hospital of Nankang District in Ganzhou City were selected.According to the principle of voluntary allocation, 45 patients in the control group received simple incision and drainage, and 45 patients in the study group received radical incision and drainage.The treatment effect, prognostic rehabilitation indexes, incidence of complications and recurrence of the two groups were compared.Results The total effective rate of treatment in the study group (95.56%) was higher than that in the control group (80.00%), and the difference was statistically significant (χ2=11.286, P＜0.05).The postoperative infection control time and hospital stay of the study group were shorter than those of the control group, and the postoperative pain score was lower than that of the control group, the differences were statistically significant (P＜0.05).The total incidence of postoperative complications and recurrence rate in the study group were 4.44% and 4.44%, respectively, which were lower than 20.00% and 24.44% in the control group, the differences were statistically significant (χ2=11.286, 16.188, P＜0.05).Conclusion The radical incision and drainage treatment program for patients with perianal abscess has a significant effect and good prognostic rehabilitation indicators, which is beneficial to the early recovery of the patients′ condition and is worthy of promotion and application.

Objective To explore the application effect of restricted fluid resuscitation in emergency pelvic fractures with hemorrhagic shock.Methods Clinical data of 98 patients of pelvic fracture with hemorrhagic shock admitted to the Emergency Surgery of Shunyi District Hospital of Beijing City from August 2015 to October 2019 were retrospectively analyzed, and they were divided into the restricted group (51 cases) and the control group (47 cases) according to the different fluid resuscitation methods.The control group used conventional fluid resuscitation and the restricted group used restrictive fluid resuscitation.The acute respiratory distress syndrome(ARDS),multiple organ dysfunction syndrome(MODS)and mortality were compared between the two groups, and the clinical and laboratory and oxygen metabolism indexes were compared between the two groups.Results ARDS, MODS and mortality in restricted group were lower than those in control group, and the differences were statistically significant (P＜0.05).After resuscitation, the ISS score in the restricted group was lower than that in the control group, the resuscitation time was shorter than that in the control group,and the infusion volume was lower than that in the control group, the differences were statistically significant (P＜0.05).The serum lactate content in the restricted group after resuscitation was lower than that in the control group, the prothrombin time (PT) was shorter than that in the control group, hematocrit (HCT) and blood platelet (PLT) levels were higher than those in the control group, the differences were statistically significant (P＜0.05).Before treatment, there was no significant difference in oxygen metabolism between the two groups (P＜0.05).After treatment, CaO2 and O2ER in the restricted group were higher than those in the control group, while Da-jvO2 in the restricted group was lower than that in the control group, and the differences were statistically significant (P＜0.05).Conclusion Restrictive fluid resuscitation in emergency treatment of pelvic fracture with hemorrhagic shock, the success rate of rescue is high, the time of resuscitation is short, and the incidence of complications is low, it is worthy of further clinical promotion.

Objective To investigate the effectiveness and safety of Docetaxel combined with Anlotinib in the secondline treatment of advanced non-small cell lung cancer (NSCLC), in order to improve the quality of life of patients.Methods A total of 48 cases of NSCLC patients admitted to Jiangxi Chest Hospital from January 2018 to December 2019 were selected as the research objects.According to the random number table method, they were divided into the experimental group and the control group, with 24 cases in each group.The experimental group was treated with oral Anlotinib Hydrochloride combined with Docetaxel chemotherapy, and the control group was treated with Docetaxel chemotherapy.Both groups were treated for 3 months.The disease control rate (DCR), progress free survive (PFS) and the incidence of side effect during treatment were compared between the two groups.Results After 3 months of treatment, the DCR of the experimental group was higher than that of the control group, the difference was statistically significant (P＜0.05); followed up for 6 months, the PFS in the experimental group was longer than that in the control group, the difference was statistically significant (P＜0.05); the incidence of hand-foot syndrome, proteinuria, and liver and kidney damage in the experimental group was higher than the control group, and the difference was statistically significant (P＜0.05).Conclusion Docetaxel combined with Anlotinib in second-line treatment of advanced NSCLC can effectively control the progression of the disease, and the toxic and side effect of combination treatment are increased compared with simple docetaxel chemotherapy, but the toxic and side effect are all controllable after intervention.

Objective To investigate the expression and clinical significance of the G protein-coupled receptor 37(GPR37) in lung adenocarcinoma.Methods RNA sequences and clinical data from 510 lung adenocarcinoma tissues(tumor group)were downloaded from the cancer genome stlas (TCGA) database, including 56 paracancerous tissues(paracancerous control group).The correlation between GPR37 expression and clinicopathological features of lung adenocarcinoma was analyzed and compared.Results The expression level of GPR37 in the tumor group was higher than that in the paracancerons control group, and the difference was statistically significant (P＜0.05).Univariate COX logistic regression analysis showed that the expression level of GPR37 was not correlated with gender, age and M stage,and the difference was not statistically significant (P＞0.05), but was correlated with T stage and N stage, and the difference was statistically significant (P＜0.05).The results of survival prognosis analysis showed that the expression level of GPR37 was significantly correlated with the prognosis of patients with lung adenocarcinoma, and the difference was statistically significant (P＜0.05).The higher the expression was, the worse the prognosis was.Multivariate COX risk scale model results showed that high GPR37 expression level and stage were independent risk factors for poor prognosis in patients with lung adenocarcinoma.Conclusion According to the high expression of GPR37 in lung adenocarcinoma,it is speculated that GPR37 may play a certain role in the occurrence and development of lung adenocarcinoma, thus affecting the prognosis of patients with lung adenocarcinoma.Therefore, GPR37 can be used as a potential therapeutic target or diagnostic marker for lung adenocarcinoma.

Objective To investigate the effect of transurethral resection in the treatment of muscle-invasive bladder cancer.Methods A total of 54 patients with muscle invasive bladder cancer admitted to the Fifth People′s Hospital of Liaoyang City from June 2018 to August 2019 were selected as the research objects and were divided into the control group (27 cases) and the observation group (27 cases) according to the dynamic random grouping method.The control group was treated with radical cystectomy, and the observation group was treated with transurethral resection.The operation index, quality of life and postoperative recurrence rate were compared between the two groups.Results The operation time and hospitalization time in the observation group were shorter than those in the control group, the intraoperative blood loss in the observation group was less than that in the control group, the Karnofsky functional status (KPS)score of the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05); the recurrence rate of the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05).Conclusion Transurethral resection for muscle-invasive bladder cancer has a significant effect, which can not only improve the surgical indicators, but also improve the quality of life of patients and significantly reduce the recurrence rate, so it is suitable for clinical implementation and development.

Objective To investigate the clinical effect of Erlotinib in the treatment of advanced non-small cell lung cancer.Methods A total of 176 patients with advanced non-small cell lung cancer admitted to the Zhongyi Northeast International Hospital from January 2017 to June 2019 were selected as the research objects.According to the random number table method, they were divided into the control group (88 cases) and the experimental group (88 cases).The control group was treated with Docetaxel, and the experimental group was treated with Erlotinib.The 1-year survival,adverse reactions and disease remission of the two groups were compared.Results During the follow-up period of 1 year, the disease progression free survival duration of the experimental group was longer than that of the control group, the quality of life score of the experimental group was higher than that of the control group, the differences were statistically significant (P＜0.05); the total incidence rate of adverse reactions in the experimental group was lower than that in the control group, the difference was statistically significant (P＜0.05); the disease remission rate of the experimental group was higher than that of the control group, the difference was statistically significant (P＜0.05).Conclusion Erlotinib has significant clinical effect in the treatment of advanced non-small cell lung cancer, with good 1-year survival, low incidence of adverse reactions and high disease remission rate.It is recommended that this option be preferred in clinical treatment.

Objective To investigate the therapeutic effect of laparoscopic and open ovarian cyst removal and its effect on ovarian function.Methods A total of 110 cases of ovarian cyst patients admitted to the Department of Gynecology and Obstetrics of Shangrao People′s Hospital from January 2019 to April 2020 were selected as the research objects.They were divided into control group and study group according to touch ball method, with 55 cases in each group.Open ovarian cyst removal was performed in the control group, and laparoscopic ovarian cyst removal was performed in the study group.The operative cure rate and ovarian function indexes 3 months after operation were compared between the two groups.Results There was no significant difference in the operative cure rate between the two groups (P＞0.05).Three months after operation, the levels of pulsatile index (PI), resistance index (RI), serum follicle stimulating hormone(FSH) and luteinizing hormone (LH) in the study group were lower than those in the control group, the level of estradiol(E2) was higher than that in the control group, and the differences were statistically significant (P＜0.001).Conclusion Compared with open ovarian cyst removal, laparoscopic ovarian cyst removal has better therapeutic effect and outstanding advantages in improving the ovarian function of patients, which can be used for reference.

Objective To explore clinical application of Oxytocin+COOK cervical dilatation balloon in induction of labor in full-term pregnancy.Methods A total of 70 full-term pregnant women who underwent induced labor from January 1, 2019 to June 30, 2020 in Shenyang Maternal and Child Health Hospital were selected as the research subjects.They were divided into control group (33 cases) and observation group (37 cases) according to sequential sampling method.The control group was induced by Oxytocin, while the observation group was treated by Oxytocin+COOK cervical dilatation balloon.The effect of promoting cervical maturation, labor time, cervical score, induced labor index and neonatal condition were compared between the two groups.Results The total effect rate of promoting cervical maturation in observation group was higher than that in control group, and the difference was statistically significant (P＜0.05).The first stage of labor, the second stage of labor and the third stage of labor in the observation group were shorter than those in the control group, and the Bishop score was higher than that in the control group, the differences were statistically significant (P＜0.05).The induction time of labor and the time of fetal delivery in the observation group were shorter than those in the control group, and the amount of bleeding 24 h after delivery was less than that in the control group, the differences were statistically significant (P＜0.05).The Apgar score of neonates in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The neonatal birth weight of the observation group was greater than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion It is suggested to adopt Oxytocin combined with COOK cervical dilatation balloon scheme for fullterm pregnant women to implement induced labor, which can effectively improve the effect of induced labor and improve the prognosis of pregnant women.

Objective To investigate the correlation of insulin-like growth factor 1 (IGF-1) with albumin and blood lipid in preschool children with nephrotic syndrome (NS).Methods A total of 30 preschool NS children with insensitivity to hormones, refractory or recurrent nephrotic diseases and requiring long-term oral prednisone treatment were selected as the NS group.30 healthy children of the same age were selected as the control group.The levels of IGF-1,albumin, cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) in two groups were detected, and the correlation between IGF-1 and albumin, TC, TG and LDL were analyzed.Results The levels of IGF-1 and albumin in NS group were lower than those in control group, and the differences were statistically significant (P＜0.01), while the levels of TC, TG and LDL were higher than those in control group, and the differences were statistically significant (P＜0.01).There was a positive correlation between serum albumin and IGF-1 level in NS group (r=0.64, P＜0.01).TC, TG and LDL were negatively correlated with serum IGF-1 level (r=-0.72, -0.65, -0.77, P＜0.01).Conclusion There was a correlation between serum albumin and blood lipid and IGF-1 in preschool NS children.

Objective To explore the clinical effect of laparoscopic surgery and transvaginal surgery in the treatment of uterine leiomyoma.Methods A total of 94 patients with uterine leiomyoma admitted to Huludao Lianshan People′s Hospital of Liaoning Province from February 2018 to February 2020 were enrolled, they were divided into laparoscopic group and transvaginal group according to the surgical method, 47 cases in each group.Laparoscopic group received laparoscopic surgery, transvaginal group received transvaginal surgery.The operation status, postoperative recovery status,postoperative ovarian function, sexual life indicators and the occurrence of complications were compared between the two groups.Results The operation time, the first time to go to the ground, the recovery time of gastric function and hospitalization time in the laparoscopic group were shorter than those in the transvaginal group, and the intraoperative blood loss was less than that in the transvaginal group, the differences were statistically significant (P＜0.05).Compared with before treatment, the levels of follicle-stimulating hormone, luteinizing hormone and sexual life in the two groups were higher than those at before treatment, E2 and AFC levels were lower than those at before treatment, the differences were statistically significant (P＜0.05).The total complication rate of laparoscopic group was 2.13%, the total complication rate of transvaginal group was 14.89%, the total complication rate of the laparoscopic group was lower than that of the transvaginal group, the difference was statistically significant(P＜0.05).Conclusion Laparoscopic surgery is more effective and safe in the treatment of uterine leiomyoma than transvaginal surgery.

Objective To explore the application value of noninvasive DNA detection in abnormal soft index of single ultrasound.Methods A total of 600 pregnant women with single ultrasound positive soft index in Heze Maternal and Child Health and Family Planning Service Center from March 12, 2017 to April 20, 2020 were selected as the research objects.The results of induced labor or live birth were used as the gold standard for diagnosis, and non-invasive DNA screening and pregnancy outcome were analyzed.Results Of the 600 pregnant women with positive ultrasonographic soft index, 12 were found to be high risk fetuses by non-invasive DNA examination.By amniotic fluid karyotype analysis, 8 cases were diagnosed with trisomy 21 syndrome, 1 case with trisomy 18 syndrome, 1 case with trisomy 13 syndrome, 1 case with abnormal chromosome number and 1 case with no abnormal karyotype.The sensitivity, specificity,accuracy, misdiagnosis rate and missed diagnosis rate of noninvasive prenatal DNA testing were 84.62%, 99.83%,99.50%, 0.17% and 15.38%, respectively.Patients diagnosed with trisomy 18, trisomy 13, and trisomy 21 with abnormal karyotypes eventually underwent labor induction.One pregnant woman with abnormal number of XYY chromosome chose to deliver at term.Conclusion Non-invasive DNA technology can detect fetal chromosomal abnormalities as early as possible, and has a high accuracy in fetal screening, which is conducive to reducing the risk of abortion and improving the birth quality of population, it is worth popularizing.

Objective To explore the clinical effect of Budesonide plus Salbutamol in the treatment of bronchiolitis in children.Methods A total of 100 children with bronchiolitis who were admitted to Xiamen Children′s Hospital from January 2019 to January 2020 were selected as the research subjects.According to the simple randomization method,they were divided into experimental group (50 cases) and control group (50 cases).The control group was treated with Budesonide, while the experimental group was treated with Budesonide combined with Salbutamol.The treatment effect,adverse reactions, symptom disappearance and hospitalization time of the two groups were compared.Results The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Symptoms disappeared and hospitalization time in experimental group were shorter than those in control group, the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The combination of Budesonide and Salbutamol in pediatric patients with bronchiolitis can achieve better results, shorten the recovery time, and do not increase the incidence of adverse reactions, which is of great significance.

Objective To explore the effect of Misoprostol combined with Ergonovine Maleate on coagulation function and stress response in patients with postpartum hemorrhage.Methods The clinical data of 80 postpartum hemorrhage patients admitted to the Third People′s Hospital of Benxi City from May 2018 to February 2020 were analyzed retrospectively.According to different treatment method, they were divided into control group (40 cases) and observation group (40 cases).The control group was treated with Misoprostol, while the observation group was treated with Misoprostol combined with Ergonovine Maleate.The coagulation function, stress response, bleeding after medication and the total incidence of adverse reactions were compared between the two groups before and after treatment.Results After treatment, D- dimer (D-D), prothrombin time (PT) and activated partial thromboplastin time (APTT) in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).After treatment,the levels of norepinephrine (NE) and malondialdehyde (MDA) in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The bleeding volume of the two groups at 24 h after medication was less than that at 2 h after medication, the difference was statistically significant (P＜0.05).The amount of bleeding in the observation group was less than that in the control group at 2 and 24 h after medication, the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Misoprostol combined with Ergonovine Maleate in the treatment of patients with postpartum hemorrhage can effectively improve their coagulation function and stress response, reduce postpartum hemorrhage, and without increasing the occurrence of adverse reactions at the same time, and has high clinical application value.

Objective To explore the analysis of the soft tissue profile changes in the treatment of Angle′s classⅡdivision Ⅰmalocclusion with standard square wire appliance.Methods A total of 74 children with Angle′s ⅡdivisionⅠmalocclusion admitted to Fushun Stomatological Hospital from April 2017 to March 2020 were selected as the research objects.They were divided into the study group (37 cases) and the control group (37 cases) according to lotting method.The study group was treated with a standard square wire arch appliance combined with a traditional Twin-Block appliance, while the control group was treated with a traditional Twin-Block appliance.The total scores of H angle, soft tissue buccal angle, upper lip convex distance, lower lip convex distance, and orthodontic (PAR) scores were compared between the two groups.Results The H angle, soft tissue buccal angle, upper lip convexity, and lower lip convexity of the study group were smaller than those of the control group, and the differences were statistically significant (P＜0.05).The PAR score of the study group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The standard square wire arch appliance combined with the traditional Twin-Block appliance can improve the quality of orthodontics and improve the soft tissue profile of children with Angle′s Class Ⅱdivision Ⅰmalocclusion.

Objective To investigate the clinical effect of Compound Mufurong Nasal Ointment combined with Physiological Sea Water Nasal Spray in the treatment of dry rhinitis.Methods A total of 78 patients with dry rhinitis treated in Xiangtan Central Hospital from March 2018 to February 2019 were selected as the research subjects and divided into the observation group (46 cases) and the control group (32 cases) according to the completely random method.Two groups of patients were given Physiological Sea Water Nasal Spray as the basic treatment, the observation group was given Compound Mufurong Nasal Ointment for nasal treatment, the control group was given Erythromycin Eye Ointment for nasal treatment.The clinical efficacy, symptoms and signs of the two groups were compared.Results The total effective rate of the observation group was 97.8%, which was higher than that of the control group (84.4%), and the difference was statistically significant (P＜0.05).After treatment, the scores of clinical symptoms and signs in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion Compound Mufurong Nasal Ointment has obvious advantages in the treatment of dry rhinitis on the basis of nasal rinsing treatment with Physiological Sea Water Nasal Spray.

Objective To explore the effectiveness of corneal limbal tissue transplantation in the treatment of corneal limbal defect.Methods A total of 112 patients with corneal limbal defect who were admitted to Fushun Ophthalmopathy Hospital from May 2018 to May 2019 were selected as the research subjects.All patients had a single affected eye and were divided into study group (n=56) and control group (n=56) according to the random number table method.The superficial cornea was partially excised in the control group, while the corneal limbal tissue graft was applied in the study group.The inflammatory response, clinical cure rate, recurrence rate, satisfaction degree and quality of life of the two groups were compared.Results The incidence of inflammatory reaction in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05).The cure rate of patients in the study group was higher than that in the control group, and the recurrence rate after treatment was lower than that in the control group,the differences were statistically significant (P＜0.05).The treatment satisfaction and quality of life score of patients in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion The application of corneal limbal tissue transplantation in the clinical treatment of ocular surface diseases can effectively improve the clinical treatment effect of patients, reduce the recurrence rate of patients, effectively improve the vision of patients, improve the quality of life of patients, and the satisfaction of patients with treatment is high, clinical effect is ideal, so it should be further promoted and applied clinically.

Objective To investigate the effect of different root canal filling levels in patients with acute pulpitis during root canal therapy.Methods A total of 84 patients with acute pulpitis who underwent root canal therapy in Shanghai Hospital of Wanzhou District in Chongqing City from March 2019 to April 2020 were selected as the research subjects.They were divided into control group (n=42) and observation group (n=42) by random number table method.In the control group, root canal underfilling was used, and in the observation group, proper root canal filling was adopted.The treatment effect and quality of life scores of the two groups were compared.Results The total effectiveness rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Before treatment, there was no statistical significance in the quality of life scale (SF-36) score between the two groups (P＞0.05).After treatment, the scores of physical function, physical function, physical pain, vitality, social function, emotional function, mental health and overall health in the two groups were higher than those before treatment, with statistical significance (P＜0.05).After treatment, the scores of physical function, physical function, physical pain, vitality, social function, emotional function, mental health and overall health in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion When patients with acute pulpitis undergoing root canal therapy, they must choose an appropriate amount of filling in order to ensure the clinical treatment effect, thereby improving the quality of life of the patients.Appropriate filling in root canal therapy has a positive effect on the prognosis of patients, which is worthy of popularization and application.

Objective To explore and analyze the effectiveness of Pranoprofen Eye Drops in the treatment of postoperative inflammation of cataract.Methods From January 2015 to June 2020, a total of 80 patients with postoperative cataract inflammation treated in the Affiliated Hospital of Chifeng College were selected as the research subjects.They were divided into control group and observation group by the random number table method, with 40 cases in each group.The patients in the control group were treated with Fluorometholone Eye Drops, and the patients in the observation group were treated with Pranoprofen Eye Drops.The postoperative inflammatory index levels, eye symptom scores and changes in intraocular pressure were compared between the two groups.Results After 4 weeks of treatment, the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) in the two groups were lower than before treatment, and the levels of IL-6, TNF-α and CRP in observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).After 1 week of treatment, the ocular symptom scores of the two groups were lower than those before treatment, the differences were statistically significant (P＜0.05);After 3 weeks of treatment, the ocular symptom scores of the two groups were lower than those after 1 week of treatment, the differences were statistically significant (P＜0.05).After 4 weeks of treatment, the ocular symptom scores of the two groups were lower than those after 3 weeks of treatment, the differences were statistically significant (P＜0.05).After 1, 3 and 4 weeks of treatment, eye symptom scores in observation group were all lower than those in the control group, the differences were statistically significant (P＜0.05).After 1 week of treatment, intraocular pressure levels in the two groups were lower than those before treatment,the differences were statistically significant (P＜0.05).After 3 weeks of treatment, the intraocular pressure levels of the two groups were lower than those after 1 week of treatment, the differences were statistically significant (P＜0.05).After 4 weeks of treatment, the intraocular pressure levels in the two groups were lower than those after 3 weeks of treatment, the differences were statistically significant (P＜0.05).After 1, 3 and 4 weeks of treatment, intraocular pressure levels in observation group were lower than those in the control group, the differences were statistically significant(P＜0.05).Conclusion Pranoprofen Eye Drops can effectively alleviate postoperative inflammatory reaction in patients,improve patients′ ocular symptoms, reduce intraocular pressure, and enhance ocular function.It is worthy of promotion.

Objective To explore the clinical value of coronary heart disease diagnosed by coronary CT angiography.Methods A total of 56 patients suspected with coronary heart disease who underwent coronary artery angiography and coronary CT angiography in Guangdong Provincial People′s Hospital Zhuhai Hospital (Zhuhai Golden Bay Central Hospital) from April 2018 to November 2019 were selected as the research subjects.The positive results, the diagnosis of coronary stenosis and the results of the two methods were compared, and the sensitivity, specificity, positive predictive value and negative predictive value were observed.Results The tested positive of coronary CT angiography were 105 counts, tested positive of coronary artery angiography were 95 counts, anastomosis positive rate was 87.3% (83/95), two grade stricture coincidence rate of coronary CT angiography was 55.6% (5/9), three grade stricture coincidence rate was 88.9% (32/36), four grade stricture coincidence rate was 91.3% (42/46), five grade stricture coincidence rate was 100.0% (4/4).Coronary angiography result was 100% standard, sensitivity, specificity, positive predictive value of two inspection modes were compared, the differences were statistically significant (P＜0.05).There was no significant difference in negative predictive value of two inspection modes (P＞0.05).Conclusion The diagnosis coronary heart disease by coronary artery angiography and coronary CT angiography have no obviously difference, repeatability is good, which could be important method of coronary heart disease screening, it has certain clinical value.

Objective To compare the value of 3.0T magnetic resonance imaging (MRI) and transrectal ultrasonography(TRUS) in preoperative diagnosis of anal fistula.Methods A total of 100 patients undergoing elective anal fistula surgery admitted to Shangrao People′s Hospital from February 2018 to September 2020 were selected as the research objects.All patients underwent 3.0T MRI and TRUS examination, the surgical results were taken as the gold standard,the consistency of the diagnostic coincidence rate of MRI and TRUS in preoperative diagnosis of anal fistula, detection of anal fistula typing and with the surgical results was compared.Results Diagnosed by the results of surgery, among 100 patients with anal fistula, 62 cases were intersphincteric fistulas, 29 cases were transsphincteric fistulas, 4 cases were suprasphincteric fistulas, and 5 cases were external sphincteric fistulas; there were 104 main ducts, 92 branch ducts, and 152 internal opening; 60 abscesses.The detection coincidence rate of main ducts, branch ducts and internal opening of MRI examination was higher than that of TRUS examination, the differences were significant statistically (P＜0.05).There was no statistically significant difference in the coincidence rate of abscesses between the two examinations (P＞0.05).The accuracy of MRI diagnosis of anal fistula classification was 96.00% (96/100), higher than 86.00%(86/100)of TRUS,the difference was significant statistically(P＜0.05).According to Kappa consistency measure, the consistency between MRI diagnosis of anal fistula classification and surgical results was (Kappa=0.925, P=0.000),which was higher than that of TRUS diagnosis (Kappa=0.739, P=0.000).Conclusion 3.0T MRI has high accuracy and no damage in preoperative detection and evaluation of patients with anal fistula.TRUS also has high accuracy, fast inspection and easy operation.The accuracy of MRI is higher than that of TRUS, but the rapidity and simplicity of MRI is weaker than that of the TRUS, it is necessary to select or combine them according to the situation, which can accurately evaluate the operation, improve the cure rate and reduce the recurrence rate.

Objective To explore the application value of spiral CT scanning and three-dimensional reconstruction technology in Garden classification of femoral neck fracture.Methods Clinical data of 231 patients with femoral neck fracture treated in Fushun Central Hospital from September 2017 to September 2018 were retrospectively analyzed, and they were divided into experimental group (n=114) and reference group (n=117) according to different diagnostic methods.The reference group underwent X-ray positron radiography, while the experimental group underwent spiral CT scanning and three-dimensional reconstruction technology.The accuracy rate, misdiagnosis rate, missed diagnosis rate,internal fixation of fracture and follow-up results were compared between two groups.Results The accuracy rate of the experimental group was higher than that of the reference group, and the misdiagnosis rate and missed diagnosis rate of the experimental group were lower than those of the reference group, the differences were statistically significant (P＜0.05).The rate of osteonecrosis, fracture healing rate and mortality of the experimental group were lower than those of the reference group, the differences were statistically significant (P＜0.05).Conclusion Spiral CT scanning and threedimensional reconstruction technology has application value in Garden classification of femoral neck fracture, which can more comprehensively observe the injury of patients with femoral neck fracture and accurately determine the fracture classification, which is conducive to the selection of surgical scheme for clinicians and improve the prognosis.

Objective To explore the clinical effect of Cinnamon Powder treating diabetic peripheral neuropathy.Methods Clinical data of 94 patients with diabetic peripheral neuropathy admitted to Huanggu District Central Hospital of Shenyang City from January 2017 to December 2019 were retrospectively analyzed, and they were divided into the conventional group and the study group according to different treatment methods, with 47 cases in each group.The conventional group was given conventional basic treatment, and the blood glucose was controlled by diet and insulin injection.The study group was treated with Cinnamon Powder.The Toronto clinical scoring system (TCSS) score, traditional Chinese medicine syndrome score (lumbago and knee weakness, limb pain, dry mouth, intermittent claudication,mental fatigue), sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of the common peroneal nerve before treatment and 28 days after treatment, therapeutic effect, and total incidence of adverse reactions were compared between the two groups.Results Before treatment, there were no significant differences in TCSS score,traditional Chinese medicine syndrome score, SNCV and MNCV between the two groups (P＞0.05).After treatment, the TCSS scores and traditional Chinese medicine syndrome scores of the two groups were lower than those before treatment, the SNCV and MNCV of the two groups after treatment were higher than those before treatment, the differences were statistically significant (P＜0.05).The TCSS score and TCM syndrome score in the study group were lower than those in the conventional group, SNCV and MNCV were higher than those in the conventional group, the differences were statistically significant (P＜0.05).The total effective rate of treatment in the study group was higher than that in the conventional group, the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Cinnamon Powder in the treatment of diabetic peripheral neuropathy could improve the symptoms of patients with lumbar and knee soreness, limb pain, dry mouth and polydipsia, repair the damaged nerves, improve the conventional treatment effect, with fewer adverse reactions, high safety, and ideal clinical application effect.

Objective To investigate the application effect of WeChat group regular education in the use of inhalers in patients with chronic obstructive pulmonary disease (COPD) at stable stage.Methods A total of 70 patients with COPD at stable stage admitted to Yichun Second People′s Hospital from October 2017 to October 2019 were selected as study subjects.They were divided into the control group(35 cases)and the study group(35 cases)according to random number table method.The control group adopted the conventional nosocomial drug education method, and the study group established the WeChat group with doctors, pharmaceutists and nurses on the basis of the control group, and regularly distributed the health education related knowledge and various inhalation agent use methods.The inhaler use technique score,medication compliance, lung function indicators, and oral Candida infection rates were compared between the two groups before and after intervention.Results After 6 months of intervention,the inhaler use technique score of the study group was(5.80±0.83) points, which was higher than that of the control group ([4.14±0.94]points), with statistically significant difference (P＜0.05).The medication compliance score of the study group was (6.25±1.33) points, which was higher than that of the control group([5.01±1.61]points),with statistically significant difference(P＜0.05).The percentage of predicted value of forced expiratory volume in one second (FEV1%) in the study group was (61±4)%, which was higher than that in the control group ([56±4]%), and the difference was statistically significant (P＜0.05).The infection rate of oral Candida in the study group was 8.6%, which was significantly lower than that in the control group of 31.4%, and the difference was statistically significant (P＜0.05).Conclusion WeChat group regular education is beneficial to the improvement of inhalant operation technique and medication compliance in patients with COPD in stable period, which is worthy of further discussion and promotion in clinical practice.

Objective To investigate the effect of Enalapril Maleate and Irbesartan in the treatment of H-type hypertension on plasma homocysteine(Hcy)and blood pressure.Methods A total of 80 H-type hypertension patients who were admitted to the Fuzhou Workers Medical Insurance Outpatient Clinic from January 2018 to April 2019 were selected as subjects.They were divided into control group and observation group according to the random number table method, with 40 cases in each group.In the control group, Irbesartan alone was used, and in the observation group, Enalapril Maleate Tablets was adopted.The plasma Hcy and blood pressure levels of two groups before treatment and 1, 3 and 6 months after treatment were compared, and the incidence of adverse reactions in the two groups was observed.Results The plasma Hcy levels of two groups after 1, 3 and 6 months of treatment were lower than those before treatment, and the plasma Hcy levels of observation group after 1, 3 and 6 months of treatment were lower than those of control group, the differences were statistically significant (P＜0.05).The levels of systolic blood pressure (SBP) and diastolic blood pressure(DBP) of two groups after 1, 3 and 6 months of treatment were lower than those before treatment, and the levels of SBP and DBP in observation group after 1, 3 and 6 months of treatment were lower than those in the control group, the differences were statistically significant (P＜0.05).During the treatment, no adverse reactions occurred in the two groups.Conclusion Compared with Irbesartan, Enalapril Maleate in the treatment of H-type hypertension can reduce the plasma Hcy and blood pressure levels of patients, which is conducive to the recovery of patients, and is worthy of clinical application.

Objective To explore the clinical effect of Sheduqing Mixture, bloodletting combined with routine western medicine in the treatment of Naja bite.Methods A total of 60 patients with Naja bite treated in Department of Emergency, Shenzhen Traditional Chinese Medicine Hospital from March 2017 to March 2019 were selected as the research objects.They were divided into the treatment group and the control group according to random number table method,with 30 cases in each group.In the control group, routine western medicine were used.In the treatment group, oral administration of Sheduqing Mixture combined with bloodletting therapy was used on the basis of the control group.Both groups were treated for 1 week.Serum creatine kinase (CK), plasma coagulation indexes such as prothrombin time (PT),activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FG) level, skin tissue necrosis score and clinical efficacy were compared between the two groups before and after treatment.Results After 3 days of treatment,the serum CK level and skin tissue necrosis score in the treatment group were lower than those in the control group,and the differences were statistically significance (P＜0.01).After 1 week of treatment, plasma PT, APTT and TT in the treatment group were shorter than those in the control group, and the level of Fg in the treatment group was higher than that in the control group, the differences were statistically significance (P＜0.05).The total efficiency in treatment group was higher than that in control group, and the difference was statistically significant (P＜0.01).Conclusion On the basis of routine western medicine, the intervention of Sheduqing Mixture and bloodletting therapy could effectively improve the coagulation indexes and the tissue necrosis situation of the Naja bite patients and enhance the total clinical obviously effective rate, with the therapeutic efficacy superior to the simple routine western medicine intervention.

Objective To investigate the clinical effect of Tiotropium Bromide combined with Bufei Huoxue Capsules in the treatment of pneumoconiosis.Methods The clinical data of 82 patients with pneumoconiosis admitted to the Fifth People′s Hospital of Ganzhou City from January 2017 to December 2019 were retrospectively analyzed.According to different treatment methods, they were divided into the control group (Tiotropium Bromide was used for treatment, 40 cases) and the observation group (Tiotropium Bromide+ Bufei Huoxue Capsules was used for treatment, 42 cases), and all were treated for 12 weeks.The scores of lung function, symptoms and signs were compared between the two groups before treatment and 12 weeks after treatment.Results After 12 weeks of treatment, the forced expiratory volume per second (FEV1), peak expiratory flow rate (PEF) and forced vital capacity (FVC) levels in two groups were higher than those before treatment, the FEV1, PEF and FVC levels in observation group were higher than those in control group,and the differences were statistically significance (P＜0.05).After 12 weeks of treatment, symptom and sign scores of two groups were lower than those before treatment, the symptom and sign score of observation group was lower than control group, and the differences were statistically significant (P＜0.05).Conclusion Tiotropium Bromide combined with Bufei Huoxue Capsules can effectively improve the pulmonary function and symptom and sign scores of patients with pneumoconiosis.

Objective To investigate the effect of Colchicine and Febuxostat combined with external application of Phellodendra and Rhubarb in the treatment of elderly patients with acute gouty arthritis.Methods A total of 104 elderly patients with acute gouty arthritis admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from February 2019 to July 2020 were selected as the research objects and divided into the control group, observation Ⅰ,Ⅱ, Ⅲgroup by random number table method, with 26 cases in each group.Control group was treated by oral colchicine treatment, observation Ⅰgroup was treated by oral Colchicine and Febuxostat, observation Ⅱgroup was treated by oral Colchicine combined with external application of Phellodendra and Rhubarb, observation Ⅲgroup was treated by oral Colchicine and Febuxostat combined with external application of Phellodendra and Rhubarb.After treatment, the difference of joint circumference, blood uric acid level and treatment effect of four groups were compared.Results After treatment, the joint diameter differences of the observation Ⅰ, Ⅱgroup were smaller than those of the control group, and the joint diameter difference of the observation Ⅲgroup was smaller than that of the control group, observation Ⅰ, Ⅱgroup, the differences were statistically significance (P＜0.05).The levels of blood uric acid in observation Ⅰ, Ⅲgroup were lower than those in control group and observation Ⅱgroup, and the differences were statistically significant (P＜0.05).The total effective rate of observation Ⅲgroup was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Oral Colchicine And Febuxostat combined with external application of Phellodendron and Rhubarb can effectively improve the therapeutic effect of elderly patients with acute gouty arthritis.

Objective To summarize and analyze the regularity and characteristics of adverse drug reactions (ADR) in Jiangmen Central Hospital (hereinafter referred to as "our hospital"), so as to provide reference for clinical medication and promote safe and rational drug use.Methods Altogether 1068 cases of ADR in our hospital from 2018 to 2019 were collected for retrospective analysis, which mainly involved the status and association evaluation of ADR, gender,age, administration mode, drug classification and variety, organs/systems and clinical symptoms.Results In 1068 cases of ADR, 810 cases (75.8%) were in general state and 258 cases (24.2%) were serious.Female was slightly more than male (5∶4), and 692 cases were over 51 years old (64.8%).A total of 725 cases (67.9%) were mainly given by intravenous drip, and most of them occurred on the same day of medication.All 261 varieties of 14 kinds of drugs were involved in ADR, mainly including 52 anti-infective drugs and 45 anti-tumor drugs.The main clinical symptoms were damage to the skin, its appendages and digestive system, involving 10 systems.Conclusion There are various factors that affect ADR.The clinic should pay attention to the medication of special population, strengthen the monitoring and reporting quality of ADR, improve the reporting rate, reduce the missing report and false report, and promote the medication safety of patients.

Objective To explore the clinical effect of rehabilitation nursing at different time on postpartum pelvic floor function.Methods A total of 62 cases of normal delivery women who were admitted to Jingdezhen Maternal and Child Health Hospital of Jiangxi Province from January 2018 to January 2020 were selected as the research objects.According to the random lottery method, they were divided into observation group (31 cases) and control group (31 cases).The control group was treated with rehabilitation care from 2 months after delivery, while the observation group was treated with rehabilitation care from 1 month after delivery.The pelvic floor muscle strength, urinary incontinence and pelvic floor pressure recovery rate after the nursing were compared between the two groups.Results After nursing, the firstclass fiber machine voltage, the second-class fiber voltage of pelvic floor muscle and the cross-sectional muscle strength of hand vagina in the observation group were higher than those in the control group, and the differences were statistically different (P＜0.05).The incidence of urinary incontinence in the observation group after nursing was 9.70%,which was lower than that in the control group (29.00%), and the dfference was statistically significant (P＜0.05).The recovery rate of pelvic floor pressure in the observation group after nursing was 96.70%, which was higher than that in the control group (71.00%), and the difference was statistically significant (P＜0.05).Conclusion Postpartum rehabilitation nursing can improve pelvic floor muscle strength, reduce the incidence of urinary incontinence, and recover pelvic floor pressure well, which is worthy of populariation.

Objective To explore the effect of active thermal insulation nursing intervention during operation on placental cesarean section for postpartum hypothermia.Methods Retrospectively analyze the clinical data of 80 cases of maternal cesarean section who were treated in Nanchang Ren′ai Maternity Hospital in Jiangxi Province with placenta previa between January 2018 and December 2019, and 40 cases of women with routine thermal insulation during operation were included in the control group.Parturients who took active thermal care interventions were included in the study group.The temperature changes, tremor scores, and hypothermia chilling rates of the two groups at different times were compared.Results Before anesthesia(T0),there was no statistically significant difference in body temperature between the two groups (P＞0.05); after the onset of anesthesia (T1), after fetal delivery (T2), and at the end of the operation (T3),the body temperature of the study group were higher than those of the control group, the differences were statistically significant (P＜0.05).After nursing, the tremor score and the incidence of hypothermia and chills in the study group were lower than those in the control group, and the total satisfaction was higher than that in the control group, the differences were statistically significant(P＜0.05).Conclusion Intraoperative active thermal care can reduce the incidence of hypothermia and tremor in women undergoing placenta previa cesarean section, and reduce the degree of chills.

Objective To explore the application effect of self-management education combined with high-quality nursing in community elderly patients with chronic obstructive pulmonary disease (COPD).Methods From January 2019 to February 2020, 40 elderly COPD patients admitted to Jiujiang First People′s Hospital, Jiangxi Province were selected as the research subjects.They were divided into the control group (n=20) and the observation group (n=20) by using random number table method.In the control group, high-quality nursing was used, and in the observation group, selfmanagement education combined with high-quality nursing was used.The self-care ability and mental state of the two groups of patients before and 30 days after nursing were compared between the two groups.The compliance behavior was also compared.Results After 30 days of nursing, the scores of self-care ability of the two groups were higher than those before nursing, and the score of self-care ability of the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05).After 30 days of nursing, the scores of self-rating scale(SAS) and self-rating depression scale (SDS) were lower than before nursing, and the SAS and SDS scores of the observation group were lower than those of the control group, with statistical differences (P＜0.05).After 30 days of nursing,the regular medication rate of the observation group was 90.00, and the medication compliance rate was 95.00%, and the moderate exercise rate was 85.00%, higher than those of the control group, accounting for 60.00%, 65.00%, and 55.00%, the differences were statistically significant (P＜0.05).Conclusion Self-management education combined with high-quality nursing can improve the self-care ability of elderly COPD patients in the community, improve their psychological state, and strengthen patients′ compliance behaviors, which is worthy of promotion.

Objective To study the application evaluation and complications of implantable intravenous infusion port(VAP) in breast cancer patients undergoing chemotherapy.Methods A total of 100 breast cancer patients who received chemotherapy in Jiangxi Cancer Hospital from January 2017 to December 2019 were selected and randomly divided into the control group (n=50) and the observation group (n=50).Central venous catheterization was used in the control group and VAP catheterization was used in the observation group.The quality of life and complications of the two groups were compared.Results There was no significant difference in the quality of life between two group before catheterization (P＞0.05).After catheterization, the scores of physiological function, emotional function, mental health,physical health and mental health of the two groups were lower than those before catheterization, while the score of physical pain was higher than that before catheterization, and the differences were statistically significant (P＜0.05).The scores of overall health self-evaluation, vitality, social function, emotional function, mental health mental health in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).There were no significant difference in the scores of physiological function, physiological function, body pain physical health between the two groups (P＞0.05).There was no significant difference in the total incidence of catheter failure,catheter-related thrombus, puncture site infection, unplanned extubation and other complications between the two groups (P＞0.05).Conclusion VAP can significantly improve the quality of life of patients with breast cancer and has clinical application value.

Objective To explore the application effect of chronic obstructive pulmonary disease (COPD) nursing specialist clinics in pulmonary rehabilitation training for patients with COPD in stable period.Methods A total of 30 patients with COPD in stable period treated in Pingxiang People′s Hospital from June 2019 to October 2020 were selected and divided into the control group and the promotion group by random number table methods, with 30 cases in each group.The control group took routine outpatient nursing intervention, and the promotion group took the COPD nursing specialist outpatient nursing intervention on the basis of the control group.Both interventions were conducted for 12 weeks.The pulmonary function indexes, degree of disease condition and Beek depression inventory (BDI) scores were compared between the two groups before and 12 weeks after intervention.Results After 12 weeks of intervention, the ratio of forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) in the promotion group were higher than those in the control group,the differences were statistically significant (P＜0.05).After 12 weeks of intervention, the COPD assessment test (CAT)score of the promotion group was lower than that of the control group, and the difference was statistically significant (P＜0.05).After 12 weeks of intervention, the BDI score of the promotion group was lower than that of the control group, the difference was statistically significant (P＜0.05).Conclusion COPD nursing specialist clinic in pulmonary rehabilitation training for patients with COPD in stable period can effectively control the condition of patients′ disease, improve patients′ lung function and relieve depression.

Objective To explore application value of implementing special comprehensive nursing intervention for patients with macular degeneration.Methods From January 2018 to March 2020, 100 patients with macular degeneration admitted to Fuzhou First People′s Hospital, Jiangxi Province were selected as research subjects.They were divided into the control group and the observation group according to random number table method, 50 cases in each group.There were 152 affected eyes in total, 76 eyes in each group.In the control group, patients were implemented with conventional nursing, and in the observation group, special comprehensive nursing intervention was used.The anxiety situation, quality of life score, sleep quality, and complications of patients in the two groups were compared.Results The anxiety self-rating scale (SAS) scores of the two groups before the intervention, the difference had no statistical significance (P＞0.05).The SAS scores of the two groups after intervention were lower than those before the intervention, the SAS score in the observation group was lower than that of the control group, with statistical differences (P＜0.05).The scores of physical function, social function, emotional role, and mental health in the two groups before the intervention,the differences had no statistical significance (P＞0.05).After the intervention, the scores of physical function, social function, emotional role, and mental health in the two groups were higher than those before the intervention, the scores of physical function, social function, emotional role, and mental health in the observation group were higher than those of the control group, with statistical differences (P＜0.05).After the intervention, the scores of sleep quality, time to fall asleep, sleep time, sleep efficiency, sleep disorders, hypnotic drugs, and daytime dysfunction in the observation group were lower than those of the control group, with statistical differences (P＜0.05).After the intervention, the total incidence of complications in the observation group was 12.00%, lower than that in the control group accounting for 42.00%, with statistical difference (P＜0.05).Conclusion The implementation of special comprehensive nursing intervention for patients with macular degeneration has an important effect.It can decrease the anxiety score of patients, improve the quality of life, improve the sleep quality, and reduce the incidence of complications, which is worthy of widespread clinical application.

Objective To explore the influence of nursing intervention based on motivational interview (MI) in peritoneal dialysis (PD) patients.Methods A total of 152 patients who underwent PD treated in Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University from April 2018 to April 2020 were selected.They were divided into the control group (n=76) and the observation group (n=76) according to the random number table method.In the control group, routine intervention was used, and in the observation group, MI-based nursing on this basis was implemented.The scores of volume load, self-management ability including exercise of self-care agency scale (ESCA), and health behavior tested by health promotion lifestyle profile scale Ⅱ(HPLP-Ⅱ） were compared between the two groups before and at 3 months of intervention.Results There were no statistical differences between the two groups of volume control,ESCA or HPLP-Ⅱscore before intervention (P＞0.05).After intervention, the systolic blood pressure was (132.05±5.74)mmHg, diastolic blood pressure was (72.84±3.65) mmHg, body weight was (63.32±3.22) kg in the observation group,which were all lower than those of the control group of (139.26±6.53) mmHg, (79.36±3.25) mmHg, (65.01±3.26) kg; ultrafiltration volume was (615.88±45.67) mL and urine volume was (738.69±57.28) mL in the observation group, which were less than those of the control group of (678.09±45.16) and (826.54±60.53) mL; the scores of ESCA and HPLP-Ⅱwere (114.68±9.05) and (157.93±22.54) points in the observation, both higher than those of the control group of (90.18±8.73) and (126.84±20.19) points, with statistical differences (P＜0.05).Conclusion MI nursing can improve the volume load of PD patients, enhance the level of self-management, and promote the improvement of patients′ health behavior.

Objective To explore the effect of humanized nursing intervention on cognitive function and medication compliance of schizophrenic patients in rehabilitation period.Methods A total of 60 cases of convalescent schizophrenic patients admitted to Huizhou Demobilized Veterans′ Hospital and Huizhou Second People′s Hospital from December 2017 to June 2019 were selected as the research objects,and they were divided into the control group (30 cases)and the observation group (30 cases) according to the coin toss grouping method.The control group was given routine nursing,and the observation group was given nursing intervention based on humanistic nursing on the basis of routine nursing.The positive and negative symptom scale (PANSS), nurses observation scale for inpatient evaluation (NOSIE) score,Montreal cognitive assessment (MOCA) score, social disability screening schedule (SDSS) score and medication compliance were compared between the two groups.Results The PANSS and SDSS scores of the two groups before intervention were compared, and the differences were not statistically significant (P＞0.05).The PANSS and SDSS scores of the observation group after intervention were lower than those of the control group, the differences were statistically significant (P＜0.05).The NOSIE and MOCA scores of the two groups before intervention had no statistical significance (P＞0.05), and the NOSIE and MOCA scores of the observation group after the intervention were higher than those of the control group, the differences were statistically significant (P＜0.05).The medication total compliance of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).Conclusion Humanistic nursing can improve the mental symptoms, cognitive function, social function and satisfaction of patients with schizophrenia in rehabilitation period, which is worthy of further promotion and application.

Objective To explore the application of ″one disease one product″ in the nursing of acute cerebral infarction(ACI).Methods A total of 100 patients with ACI admitted to Jingdezhen Second People′s Hospital, Jiangxi Province from March 2019 to March 2020 were selected as the research objects.According to the random grouping method, they were divided into the control group (50 cases) and the observation group (50 cases).The control group adopted the conventional nursing method, while the observation group adopted the ″one disease one product″ nursing method.The satisfaction rate, length of stay, cost of treatment, quality of life and quality of nursing were compared between the two groups.Results There was no significant difference in the total satisfaction between the two groups (P＞0.05).The length of hospital stay in the observation group was (9.68±3.28) d, shorter than that in the control group of (18.52±2.23) d, and the difference was statistically significant (P＜0.05).The treatment cost of the observation group was (10.05±1.33) thousand yuan, lower than that in the control group of (14.22±2.02) thousand yuan, the difference was statistically significant (P＜0.05).The post-nursing quality of life score of the observation group was (60.11±5.08) points, higher than that of the control group of (56.03±5.59) points, and the difference was statistically significant (P＜0.05).The comparison of the pre-nursing quality of life scores of the two groups showed no statistically significant differences (P＞0.05).The observation group′s education and nursing quality was (46.13±2.17) points，psychological nursing quality was (45.66±2.33) points，thrombolytic nursing quality was (44.29±2.66) points, were higher than those of the control group of(40.09±3.29), (39.05±3.51), (38.22±3.48) points, the differences were statistically significant (P＜0.05).Conclusion ″One disease one product″ nursing for ACI nursing, can shorten the length of hospital stay, reduce the cost of treatment, improve the quality of life and nursing quality of patients.

Objective To observe the application effect of predictive nursing in children bronchiolitis.Methods From January 2018 to December 2019, 60 cases of children bronchiolitis admitted to the Fourth People′s Hospital of Nanhai District in the Foshan City were selected and divided into two groups according to random drawing method, 30 cases in each group.The control group was given routine nursing, and the study group was given predictive nursing.The nursing effect of the two groups was compared.Results The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05); the disappearance time of cough, shortness of breath and asthma symptoms in the study group were shorter than those in the control group, the differences were statistically significant (P＜0.05); the hospitalization time of the study group was shorter than that of the control group, the difference was statistically significant (P＜0.05).After nursing, the tidal volume, peak volume ratio and peak time ratio in the study group were higher than those in the control group, and the tidal breathing peak expiratory flow rate and respiratory frequency were lower than those in the control group, the differences were statistically significant (P＜0.05).The total incidence of respiratory tract infection, wheezing recurrence and other complications in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion The implementation of predictive nursing for children bronchiolitis can improve the nursing effect, promote the improvement of clinical symptoms, shorten the length of hospital stay, improve lung function and reduce the incidence of complications.

Objective To explore the application effect of fast track surgery (FTS) combined with traditional Chinese medicine nursing in the perioperative period of urology.Methods A total of 100 cases of patients in the perioperative period admitted to Weihai Second Hospital Affiliated to Qingdao University from October 2017 to October 2019 were selected and divided into the control group and the research group using random grouping by computer, 50 cases in each group.The control group was given FTS nursing path, the research group was given FTS nursing path with nursing of traditional Chinese medicine.The total satisfaction of nursing and the total incidence of complications in two groups were compared.Results The total satisfaction of nursing in research group was higher than that in the control group,and the total incidence of complications in research group was lower than that in control group, with significant differences (P＜0.05).Conclusion The application of the concept of FTS combined with traditional Chinese medicine nursing in the perioperative period of urology patients can reduce the incidence of complications, improve the total satisfaction of nursing.

Objective To explore the application effect of respiratory rehabilitation exercises in nursing of elderly patients with stable chronic obstructive pulmonary disease (COPD).Methods A total of 100 elderly patients with stable COPD admitted to Liaoyang Central Hospital, Liaoning Province from January 2018 to January 2020 were selected as research subjects.The patients were divided into the observation group and the control group by random number table method, 50 cases in each group.Conventional treatments including (oxygen support, and drugs for expectoration, antiinfection and asthma-relieving) were used in both groups.In the control group, patients received conventional nursing intervention on the basis of conventional treatment, and in the observation group, participants received respiratory rehabilitation training nursing based on the control group.Intervention lasted two months in both groups.The forced vital capacity(FVC),the first 1 second forced expiratory volume (FEV1), peak expiratory flow rate (PEF) and exercise tolerance(6 min walking distance) were compared between the two groups before and after 2-month intervention.Results After 2 months of intervention, the values of FEV1, PEF, and FVC of the two groups were higher than those before the intervention, and the values of FEV1, PEF and FVC of the observation group were higher than those of the control group,with statistical differences (P＜0.05).After 2 months of intervention, the results of 6 min walking distance test in the two groups were longer than those before the intervention, and the 6 min walking distance test result of the observation group was longer than that of the control group, with statistical differences (P＜0.05).Conclusion Respiratory rehabilitation exercises can effectively improve the lung function of the elderly patients with stable COPD, and is beneficial to improve the exercise tolerance of the patients.