Objective To explore the application of ″one disease one product″ in the nursing of acute cerebral infarction(ACI).Methods A total of 100 patients with ACI admitted to Jingdezhen Second People′s Hospital, Jiangxi Province from March 2019 to March 2020 were selected as the research objects.According to the random grouping method, they were divided into the control group (50 cases) and the observation group (50 cases).The control group adopted the conventional nursing method, while the observation group adopted the ″one disease one product″ nursing method.The satisfaction rate, length of stay, cost of treatment, quality of life and quality of nursing were compared between the two groups.Results There was no significant difference in the total satisfaction between the two groups (P＞0.05).The length of hospital stay in the observation group was (9.68±3.28) d, shorter than that in the control group of (18.52±2.23) d, and the difference was statistically significant (P＜0.05).The treatment cost of the observation group was (10.05±1.33) thousand yuan, lower than that in the control group of (14.22±2.02) thousand yuan, the difference was statistically significant (P＜0.05).The post-nursing quality of life score of the observation group was (60.11±5.08) points, higher than that of the control group of (56.03±5.59) points, and the difference was statistically significant (P＜0.05).The comparison of the pre-nursing quality of life scores of the two groups showed no statistically significant differences (P＞0.05).The observation group′s education and nursing quality was (46.13±2.17) points，psychological nursing quality was (45.66±2.33) points，thrombolytic nursing quality was (44.29±2.66) points, were higher than those of the control group of(40.09±3.29), (39.05±3.51), (38.22±3.48) points, the differences were statistically significant (P＜0.05).Conclusion ″One disease one product″ nursing for ACI nursing, can shorten the length of hospital stay, reduce the cost of treatment, improve the quality of life and nursing quality of patients.