Abstract：Objective To investigate the clinical effect of repetitive transcranial magnetic stimulation combined with Paroxetine Hydrochloride in the treatment of post-stroke depression. Methods A total of 80 patients with post-stroke depression treated in our hospital from April 2016 to April 2019 were selected as the research objects，and they were divided into the control group (40 cases) and the observation group (40 cases) according to the blind selection grouping method. The control group was treated with Paroxetine Hydrochloride. The observation group was treated with Paroxetine Hydrochloride combined with repeated transcranial magnetic stimulation. Depression scores and serum-related indexes were compared between the two groups before and after treatment. Results There were no significant difference in the scores of Hamilton depression scale (HAMD) and Montgomery depression scale (MARDS) before treatment between the two groups (P＞0.05). After treatment，the scores of HAMD and MARDS in the observation group were lower than those in the control group，the difference were statistically significant (P＜0.05). There were no significant difference in the levels of serum brain-derived neurotrophic factor (BDNF)，neuropeptide Y (NPY) and adrenocorticotropic hormone releasing factor (CRF) between the two groups before treatment (P＞0.05). After treatment，the levels of serum BDNF and NPY in the observation group were higher than those in the control group，and the CRF level in the observation group was lower than that in the control group，and the difference were statistically significant (P＜0.05). Conclusion Repetitive transcranial magnetic stimulation combined with Paroxetine Hydrochloride in treating post-stroke depression is more effective，it can significantly alleviate the depression of patients and significantly improve the level of nerve function in the body，which is worthy of promotion and application.
胡媚; 李满连; 陈毓茜; 易林; 邹云峰; 蒋莉莉. 重复经颅磁刺激联合盐酸帕罗西汀在卒中后抑郁症患者中的应用[J]. 中国当代医药, 2020, 27(18): 63-65.
HU Mei; LI Man-lian; CHEN Yu-qian; YI Lin; ZOU Yun-feng; JIANG Li-li. Application of repetitive transcranial magnetic stimulation combined with Paroxetine Hydrochloride in patients with post-stroke depression. 中国当代医药, 2020, 27(18): 63-65.
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