Clinical effect of Mecobalamin in the treatment of cerebral infarction patients with hyperhomocysteinemia
GAO Shan-yu DING Qi
Department of Neurology, the Fifth Clinical Medical College of Yangzhou University, Changshu No.2 People′s Hospital,Jiangsu Province, Changshu 215500, China
Abstract：Objective To investigate the clinical effect of Mecobalamin in the treatment of cerebral infarction patients with hyperhomocysteinemia. Methods Sixty-four cerebral infarction patients with hyperhomocysteinemia who were treated in our hospital from February 2018 to February 2019 were selected as research subjects. They were divided into the control group and the observation group according to the random number table method, with 32 cases in each group. The patients in the control group were given conventional cerebral infarction therapy, and the patients in the observation group were given Mecobalamin on the basis of the control group. The plasma homocysteine (Hcy) concentrations and national institutes of health stroke scale (NIHSS) scores before and after treatment were observed, and the clinical efficacy and incidence of adverse reactions during treatment were compared in the two groups. Results The total effective rate of treatment in the observation group was 93.75%, which was higher than that in the control group accounting for 78.13%, and the difference was statistically significant (P＜0.05). The plasma Hcy concentrations of the two groups of patients after treatment were lower than those before treatment, and the Hcy concentration of the observation group after treatment was lower than that of the control group, the differences were statistically significant (P＜0.05). The NIHSS scores of the two groups of patients after treatment were lower than those before treatment, and the NIHSS score of the observation group after treatment was lower than that of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence rate of adverse reactions between the two groups (P＞0.05). Conclusion Methylcobalamin can remarkably improve the clinical effect in the treatment of cerebral infarction patients with hyperhomocysteinemia, greatly reduce plasma Hcy concentration, and effectively improve the neurological function.
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