仿生物电刺激技术治疗围绝经期综合征的临床效果

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摘要目的探讨仿生物电刺激技术治疗围绝经期综合征的临床效果。方法选取2016年5月～2018年6月我院门诊诊治的90 例围绝经期综合征患者作为研究对象，按抽签分组法将其分为实验组、对照组和空白对照组三组，每组各30 例。实验组给予仿生物电刺激治疗，对照组采用激素替代治疗，空白对照组采取期待治疗。比较三组治疗前后卵泡刺激素（FSH）、雌二醇（E2）和抗米勒管激素（AMH）水平和临床疗效。结果治疗前，三组患者的激素水平（FSH、E2 和AMH）比较，差异均无统计学意义（P＞0.05）。治疗后，实验组、对照组患者的FSH 水平低于治疗前，E2 水平高于治疗前，差异均有统计学意义（P＜0.05）。治疗后，空白对照组患者的FSH、E2 水平与治疗前比较，差异均无统计学意义（P＞0.05）。实验组、对照组患者治疗后的AMH 水平与本组治疗前比较，差异均无统计学意义（P＞0.05）。空白对照组患者治疗后的AMH 低于本组治疗前，差异有统计学意义（P＜0.05）。实验组、对照组患者治疗后的FSH 水平低于空白对照组，E2、AMH 水平高于空白对照组，差异均有统计学意义（P＜0.05）。实验组患者治疗后的FSH、E2、AMH 与对照组比较，差异均无统计学意义（P＞0.05）。实验组、对照组患者的治疗总有效率均高于空白对照组，差异有统计学意义（P＜0.05）。实验组患者的治疗总有效率与对照组比较，差异无统计学意义（P＞0.05）。结论仿生物电刺激技术用于围绝经期综合征的治疗中，与激素替代治疗效果相当，该方法无创无痛，值得临床推广。由于本研究时间有限，长期疗效有待追踪。

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关键词 ：围绝经期综合征, 仿生物电刺激技术, 激素替代治疗, 疗效

Abstract：Objective To explore the clinical effect of biomimetic electrical stimulation technology in the treatment of perimenopausal syndrome. Methods Totally 90 patients with perimenopausal syndrome diagnosed and treated in our outpatient clinic from May 2016 to June 2018 were selected as research subjects.According to the method of drawing lots, they were divided into three groups：experimental group, control group and blank control group, with 30 cases in each group.The experimental group was treated with biomimetic electrical stimulation, the control group was treated with hormone replacement therapy, and the blank control group was treated with expectant treatment.The levels of follicle-stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) before and after treatment and the clinical efficacy were compared among the three groups. Results The hormone levels (FSH, E2 and AMH) of the three groups before treatment were compared, and the differences were not statistically significant (P ＞0.05).After treatment, the FSH levels in the experimental group and the control group were lower than those before treatment, while the E2 level was higher than that before treatment with statistical significances (P＜0.05).After treatment, the levels of FSH and E2 in patients of the blank control group were not significantly different from those before treatment (P＞0.05).The difference in the AMH level of the experimental group and the control group before and after treatment had no statistical significance (P＞0.05).In the blank control group, the AMH level after treatment was lower than that before treatment, and the difference was statistically significant (P＜0.05).After treatment, the FSH level in the experimental group and the control group was lower than that of the blank control group, and the levels of E2 and AMH were higher than those of the blank control group with statistical significances (P＜0.05).The differences in the FSH, E2, and AMH levels after treatment between the experimental group and the control group had no statistical significance (P＞0.05).The total therapeutic effectiveness rates in the experimental group and the control group were both higher than those of the blank control group, and the differences were statistically significant (P＜0.05).The difference in the total therapeutic effectiveness rate between the experimental group and the control group had no statistical significance (P＞0.05).Conclusion The biomimetic electrical stimulation technology used in the treatment of perimenopausal syndrome has the same effect as the hormone replacement therapy.It is non-invasive and painless, which is worthy of clinical promotion.Due to limited study time,long-term effect needs to be tracked.

Key words： Perimenopausal syndrome Biomimetic electrical stimulation technology Hormone replacement therapy;Efficacy

基金资助:江西省卫生计生委科技计划项目（20177015）

作者简介: 晏三华（1982-），男，硕士，主治医师，研究方向：妇科与内分泌

引用本文:

晏三华; 杨俊; 舒俊俊; 徐明; 姜欣; 熊贤海; 高军. 仿生物电刺激技术治疗围绝经期综合征的临床效果[J]. 中国当代医药, 2020, 27(15): 112-116.
YAN San-hua; YANG Jun; SHU Jun-jun; XU Ming; JIANG Xin; XIONG Xian-hai; GAO Jun. Clinical effect of biomimetic electrical stimulation technology in the treatment of perimenopausal syndrome. 中国当代医药, 2020, 27(15): 112-116.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I15/112

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