Abstract:Objective To investigate the predictive value of combined detection of albumin (ALB), cystatin C (CysC)and bilirubin (TB) in acute cerebral infarction complicated with acute kidney injury (AKI).Methods A total of 30 patients with acute cerebral infarction and AKI admitted to our hospital from January to December 2018 were selected as the acute cerebral infarction+AKI group, 30 patients with acute cerebral infarction without AKI were selected as the acute cerebral infarction group, and another 30 healthy subjects with healthy physical examinations were selected as the controls group.The serum biochemical indicators and the national institutes of health stroke scale (NIHSS) scores were compared among each group of subjects.Logistic regression analysis was performed on the indicators with differences,and the receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the indicators.Results The levels of ALB, CysC, and high-sensitivity C-reactive protein (hs-CRP) in the acute cerebral infarction+AKI group were higher than those in the acute cerebral infarction group and control group, the TB level was lower than that in the acute cerebral infarction group and control group, the NIHSS score in the acute cerebral infarction+AKI group was higher than that in the acute cerebral infarction group, and the differences were statistically significant (P<0.05).Multivariate Logistic regression analysis showed that ALB, CysC, and TB were risk factors for acute cerebral infarction with AKI (P<0.05).ROC curve analysis showed that the area under the curve (AUC) of the combined detection of ALB,CysC, and TB was larger than that of ALB, CysC, and TB detection alone, and the differences were statistically significant (P<0.05).Conclusion ALB, CysC and TB have high predictive value for acute cerebral infarction complicated with AKI, and combined detection can improve prediction sensitivity and specificity.
池锐锋; 林冰薇; 林喜春. 清蛋白、胱抑素C及胆红素联合检测在急性脑梗死合并急性肾损伤中的预测价值[J]. 中国当代医药, 2020, 27(8): 48-50转55.
CHI Rui-feng; LIN Bing-wei; LIN Xi-chun. Predictive value of combined detection of albumin, cystatin C and bilirubin in acute cerebral infarction complicated with acute kidney injury. 中国当代医药, 2020, 27(8): 48-50转55.