Meta analysis of the relationship between menopausal related hormone therapy and cognitive function
RAN Hai-long1 ZHAO Hong-qiong1 YANG Zhu1▲ LEI Xun2 LIU Xiao-feng3
1.College of Pharmacy,Chongqing Medical University,Chongqing 400016,China;2.Department of Epidemiology,School of Public Health and Management,Chongqing Medical University,Chongqing 400016,China;3.Department of Medical Insurance,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400021,China
Abstract：Objective To investigate the relationship between menopause hormone therapy (MHT)and cognitive function.Methods RCTs about MHT and cognition were published in databases PubMed,Embase,Cochrane library,CBM,CNKI,VIP and WANFANG DATA before November 2016 were searched.Meta-analysis was performed using STATA 12.0 software after quality assessment of the literature that met the inclusion and exclusion criteria.Results Eight studies,involving 17530 patients,were included.Meta-analysis suggested that:①The effects of MHT on increasing the risk of probable dementia(HR=1.78,95%CI[1.20-2.62],P=0.004)had significant difference.②The effects of MHT on increasing the risk of mild cognitive impairment(HR=1.21,95%CI[0.94-1.55],P=0.143)had no significant difference.③The effects of MHT on global cognitive function was negative(WMD=-0.21,95%CI[-0.33--0.09],P=0.001).④MHT had no significant effect on CVLT short delay free(WMD=0.14,95%CI[-0.11-0.38],P=0.277)and category fluency(WMD=-0.16,95%CI[-0.82-0.51],P=0.647).Conclusion The Meta-analysis has revealed that in postmenopausal women over 60 years of age MHT have an adverse impact on global cognitive function,increase the risk of dementia or mild cognitive impairment and have no significant difference in specific cognitive functions.
冉海龙;赵洪琼;杨竹; 雷迅;刘晓枫. 绝经相关激素治疗与认知功能关系的Meta分析[J]. 中国当代医药, 2018, 25(11): 11-15.
RAN Hai-long;ZHAO Hong-qiong;YANG Zhu; LEI Xun;LIU Xiao-feng. Meta analysis of the relationship between menopausal related hormone therapy and cognitive function. 中国当代医药, 2018, 25(11): 11-15.
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