Abstract：ObjectiveTo explore the application value of sentinel lymph node biopsy (SLNB)in axillary lymph node dissection (ALND)of radical mastectomy.Methods50 patients with breast cancer in our hospital from April 2012 to April 2016 were selected as the study subjects and were treated with selective radical mastectomy.The patients were divided into the observation group and the control group according to whether undergoing SLNB,25 cases in each group. The observation group was given SLNB,and the control group was treated with ALND.According to the clinical pathological results,the sensitivity,specificity,accuracy and false negative rate of SLNB in predicting axillary lymph node metastasis were evaluated.Six months after operation,the outer diameters of midpoint(MP)of upper arm at affected side and uninjured side,the change rate of perimeter at 15 cm above the olecranon (C-15)were compared between the two groups.The quality of life was evaluated by quality of life(QOL)scale,and the incidence rates of complications in 1 year after operation was recorded.ResultsThe sensitivity,specificity,accuracy and false negative rate of SLNB in predicting axillary lymph node metastasis were 93.18%,83.33%,92.00%and 6.82%respectively.Six months after operation,the reduction rates of MP,C-15 and QOL score in the observation group was higher than that in control group,with significant difference (P＜0.01).The incidence rate of complications in the observation group in 1 year after operation was 4.00%, which was lower than 24.00%in the control group,with significant difference(P＜0.05).ConclusionSLNB can accurately predict axillary lymph node metastasis of breast cancer,guide the process of radical mastectomy and reduce surgical trauma and complications,it is worthy of clinical promotion and application.
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