Abstract:Objective To investigate the influence of Levosimendan on left ventricular function and hemodynamics in elderly patients with chronic heart failure (CHF).Methods A total of 60 elderly CHF patients admitted to Fushun Petrochemical General Hospital from January 2017 to January 2020 were selected as the research subjects. They were divided into the control group (n=30) and the observation group (n=30) according to the random number table method. Patients in the control group were provided with conventional treatment and Tolvaptan, and patients in the observation group were added with Levosimendan Injection on the basis of the control group. The left ventricular functions including left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDD), B-type natriuretic peptide (BNP) and hemodynamic related indexes, such as pulmonary arterial mean pressure (PAMP), pulmonary capillary wedge pressure (PCWP) and systemic vascular resistance (SVR), were compared between the two groups after 7 days of treatment. Results In the observation group, the levels of LVEDD, BNP, PAMP, PCWP and SVR after 7 days of treatment were lower than those in the control group, the LVEF level was higher than that in the control group, with statistical significances (P<0.05). Conclusion Levosimendan therapy for elderly patients with CHF can effectively improve left ventricular function and hemodynamics, and it is worthy of promotion.
郑文祥;秦建斌;亢黎;高峡. 左西孟旦对老年慢性心力衰竭患者左心功能及血流动力学的影响[J]. 中国当代医药, 2021, 28(16): 69-71.
ZHENG Wen-xiang;QIN Jian-bin;KANG Li;GAO Xia. Influence of Levosimendan on left ventricular function and hemodynamics in elderly patients with chronic heart failure. 中国当代医药, 2021, 28(16): 69-71.
Jernberg T,Lindahl B,Alfredsson J,et al.Long-Term Effects of Oxygen Therapy on Death or Hospitalization for Heart Failure in Patients With Suspected Acute Myocardial Infarction[J].Circulation,2018,138(24):2754-2762.
Sumanaru D,Josseran L,Essid A,et al.Levosimendan as Rescue Therapy for Acute Heart Failure in a Patient with Duchenne Muscular Dystrophy[J].Pediatr Cardiol,2019,40(3):668-670.