Objective To study the clinical effect of Omeprazole combined with Octreotide in the treatment of senile cirrhosis with upper gastrointestinal bleeding.Methods A total of 80 elderly patients with cirrhosis and upper gastrointestinal bleeding treated in the Fourth People′s Hospital of Shenyang City from March 2018 to March 2020 were selected as study subjects,and were divided into the observation group and the control group by the randomized sortition grouping principle,with 40 patients in each group.Patients in the observation group were treated with Omeprazole combined with Octreotide,while patients in the control group were treated with conventional treatment.The lengths of hospital stay,hemostatic time,total incidence of adverse events,blood transfusion volumes,total effective rate,hematemesis disappearance time and melena disappearance time were compared between the two groups.Results The length of hospital stay and hemostatic time of the observation group were shorter than those of the control group,and the blood transfusion volume was less than that of the control group,the differences were statistically significant (P＜0.05).The total effective rate of the observation group was higher than that of the control group,with statistically significant difference (P＜0.05).The total incidence of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The hematemesis symptom disappearance time and melena symptom disappearance time in the observation group were shorter than those in the control group,with statistically significant differences (P＜0.05).Conclusion The combination of Omeprazole and Octreotide in elderly patients with cirrhosis and upper gastrointestinal bleeding has achieved a high effective rate.It is worthy of clinical promotion.