Abstract：Objective To investigate the clinical effect of Oxaliplatin combined with chemotherapy in the treatment of colorectal cancer.Methods A total of 120 patients with colorectal cancer admitted in our hospital from April 2018 to April 2019 were selected as subjects, and they were divided into the study group (n=78) and the control group (n=42).The patients in the control group were treated with chemotherapy and patients in the study group were treated with chemotherapy combined with Oxaliplatin.The treatment effect, adverse reactions, tumor necrosis factor-α (TNF-α), and interleukin-2 (IL-2) levels were compared between the two groups.Results The total effective rate of patients in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Before treatment, there was no significant difference in TNF-α and IL-2between the two groups (P＞0.05).After treatment, the TNF-α levels in both groups were lower than before treatment, and IL-2levels in both groups were higher than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, TNF-α in the study group was lower than that in the control group, and IL-2was higher than that in the control group, with statistically significant differences (P＜0.05).Conclusion The combined application of Oxaliplatin and chemotherapy in the treatment of colorectal cancer can obviously improve the therapeutic effect and reduce the incidence of adverse reactions, which is worthy of application and promotion in various hospitals.
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