摘要目的 探讨肝硬化并发上消化道出血患者应用奥曲肽治疗的临床效果。方法 选取2017年1月～2020年1月沈阳医学院附属第二医院收治的120例肝硬化并发上消化道出血患者作为研究对象。采用随机数字表法将其分为观察组与对照组，每组60例。对照组患者采用垂体后叶素治疗，观察组患者采用奥曲肽治疗。比较两组患者的临床效果、治疗后1、2、3 d 的止血率、止血时间、随访3个月再出血率、住院时间、输血量以及不良反应总发生率。结果 观察组的治疗总有效率高于对照组，差异有统计学意义（P＜0.05）；观察组治疗后1 d 的止血率高于对照组，差异有统计学意义（P＜0.05）；两组治疗后2、3 d 的止血率比较，差异无统计学意义（P>0.05）；观察组治疗后2 d 的止血率与治疗后1 d 比较，差异无统计学意义（P＞0.05）；观察组治疗后3 d 的止血率低于治疗后1 d，差异有统计学意义（P＜0.05）；对照组治疗后2、3 d 的止血率与治疗后1 d 比较，差异无统计学意义（P＞0.05）；观察组止血时间、住院时间短于对照组，输血量少于对照组，差异有统计学意义（P＜0.05）；两组随访3个月再出血率与不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论 肝硬化并发上消化道出血应用奥曲肽治疗，可提高效果，促进更快止血，缩短止血时间与住院时间，减少输血量。
Abstract：Objective To investigate the clinical effect of Octreotide in the treatment of patients with liver cirrhosis and upper gastrointestinal bleeding.Methods A total of 120 patients with liver cirrhosis and upper gastrointestinal hemorrhage admitted to the Second Affiliated Hospital of Shenyang Medical College from January 2017 to January 2020 were selected as the research subjects.These patients were divided into an observation group and a control group by random number table method,with 60 cases in each group.Patients in the control group were treated with Pituitrin,and in the observation group,they were treated with Octreotide.The clinical effect,the hemostasis rate of 1,2,3 days after treatment,hemostasis time,3 months follow-up rebleeding rate,hospital stay,blood transfusion volume and total incidence of adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group,and the difference was statistically significant (P＜0.05).The hemostatic rate of the observation group was higher than that of the control group at 1 day after treatment,and the difference was statistically significant(P＜0.05).There were no significant differences in the hemostatic rates at 2 and 3 days after treatment between the two groups (P＜0.05).The hemostatic rate of the observation group at 2 days after treatment was not significantly different from that of 1 day after treatment(P＞0.05).The hemostatic rate of the observation group at 3 days after treatment was lower than that of 1 day after treatment,and the difference was statistically significant (P＜0.05).The hemostatic rates of the control group at the 2 and 3 days after treatment were not significantly different from those of the 1 day after treatment (P＞0.05).The hemostasis time and hospitalization time in the observation group were shorter than those in the control group,and the blood transfusion amount was less than that in the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in the rebleeding rate within 3 months follow-up rebleeding rate between the two groups compared with the total incidence of adverse reactions (P＞0.05).Conclusion The application of Octreotide in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding can improve the effect,promote fast hemostasis,shorten hemostasis time and hospital stay and reduce blood transfusion.
丁百玲. 奥曲肽治疗肝硬化并发上消化道出血患者的临床效果[J]. 中国当代医药, 2021, 28(5): 61-64.
DING Bai-ling. Clinical effect of Octreotide in the treatment of 120 patients with liver cirrhosis and upper gastrointestinal bleeding. 中国当代医药, 2021, 28(5): 61-64.
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