急性缺血性卒中伴颅内外动脉粥样硬化性狭窄与碱性磷酸酶的关系

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摘要

目的探讨急性缺血性卒中伴颅内外动脉粥样硬化性狭窄与碱性磷酸酶（ALP）的关系。方法回顾性纳入2020年1～6月在安徽医科大学第二附属医院神经内科住院的急性缺血性脑卒中患者，根据头颈部计算机断层血管造影（CTA）检查分组，颅内外动脉狭窄率≥50%者为狭窄组（颅内/颅外动脉粥样硬化性狭窄），狭窄率＜50%或无血管狭窄者为对照组（非脑动脉粥样硬化性狭窄）。收集患者人口统计学及基线临床资料，并分析不同碱性磷酸酶水平与颅内外动脉粥样硬化性狭窄发生率的关系；应用多变量Logistic 回归分析明确颅内外动脉粥样硬化性狭窄的危险因素。结果共纳入163 例患者，其中狭窄组72 例，对照组91 例。狭窄组患者的年龄、糖尿病发生率、ALP、空腹血糖、三酰甘油、低密度脂蛋白胆固醇水平均高于对照组，差异有统计学意义（P＜0.05）。随着血清ALP 水平的升高，颅内外动脉粥样硬化性狭窄发生率增加（P＜0.05）。多变量Logistic 回归分析显示，ALP（OR=1.024，95%CI：1.009～1.039，P=0.002）是颅内外动脉粥样硬化性狭窄的危险因素之一。结论血清ALP 水平与缺血性卒中患者颅内外动脉粥样硬化性狭窄有相关性，ALP 在一定程度上可以反映颅内外血管狭窄程度。

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	杜艳群
	王微
	陈楠
	方传勤

关键词 ：卒中, 动脉粥样硬化, 动脉狭窄, 碱性磷酸酶, 危险因素

Abstract：

Objective To explore the relationship between acute ischemic stroke with intracranial/extracranial atherosclerotic stenosis and alkaline phosphatase (ALP).Methods Patients with acute schemic stroke admitted to the Department of Neurology, the Second Affiliated Hospital of Anhui Medical University from January to June 2020 were enrolled retrospectively.According to the head and neck computed tomography angiography (CTA) examination, those with a stenosis rate of intracranial/extracranial arteries ≥50% were classified as the stenosis group (intracranial/extracranial atherosclerotic stenosis), and those with a stenosis rate ＜50% or without vascular stenosis were classified as the control group (non-cerebral atherosclerosis stenosis).The demographic data and baseline clinical data were collected, and the correlation between different alkaline phosphatase levels and the incidence of intracranial/extracranial atherosclerotic stenosis was analyzed.The multivariate Logistic regression analysis was used to analyze the influencing factors of intracranial/extracranial atherosclerosis in patients with acute ischemic stroke.Results A total of 163 patients were enrolled, including 72 cases in the stenosis group, 91 cases in the control group.The age, incidence of diabetes,ALP, fasting blood glucose, triglycerides, and low-density lipoprotein cholesterol levels of the stenosis group were higher than those of the control group, the differences were statistically significant (P＜0.05).With the increase of serum ALP level, the incidence of intracranial/extracranial atherosclerotic stenosis gradually increased (P＜0.05).Multivariate Logistic regression analysis indicated that serum ALP level was one of the risk factors for intracranial/extracranial atherosclerotic stenosis in ischemic stroke patients (OR=1.024, 95%CI: 1.009-1.039, P=0.002).Conclusion The serum ALP level is associated with intracranial/extracranial atherosclerotic stenosis in patients with ischemic stroke, and ALP can reflect the degree of intracranial/extracranial atherosclerotic stenosis to some extent.

Key words： Stroke Atherosclerosis Arterial stenosis;Alkaline phosphatase Risk factors

作者简介: 杜艳群（1995-），女，汉族，安徽阜阳人，安徽医科大学2018 级在读硕士研究生，研究方向：脑血管病

引用本文:

杜艳群；王微；陈楠；方传勤. 急性缺血性卒中伴颅内外动脉粥样硬化性狭窄与碱性磷酸酶的关系[J]. 中国当代医药, 2021, 28(11): 8-11转16.
DU Yan-qun； WANG Wei； CHEN Nan； FANG Chuan-qin.

Relationship between acute ischemic stroke with intracranial/extracranial atherosclerotic stenosis and alkaline phosphatase

. 中国当代医药, 2021, 28(11): 8-11转16.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I11/8

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