Abstract：Objective To investigate the effect of Pregabalin combined with Mecobalamin on neuropathic pain and adverse reactions in patients with herpes zoster, and to provide a basis for the clinical application of this therapy.Methods The clinical data of 82 patients with herpes zoster admitted to Liaoyou Baoshihua Hospital in Panjin from February 2019 to June 2020 were retrospectively analyzed.According to different treatment methods, they were divided into the observation group and the control group, with 41 cases in each group.The control group was treated with Mecobalamine, and the observation group was treated with Mecobalamine combined with Pregabalin.Neuropathic pain (visual analogue scale [VAS]score), inflammatory markers (interleukin [IL]-6, IL-8, C-reactive protein [CRP]) levels before and 2 weeks after treatment, and adverse reactions (sleepiness, fatigue, dizziness, nausea) during treatment were compared between the two groups.Results There was no significant difference in VAS score between the two groups before treatment (P＞0.05).The VAS scores in the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the VAS score of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Before treatment, there were no significant differences in the levels of IL-6, IL-8 and CRP between the two groups (P＞0.05).After treatment, the levels of IL-6, IL-8 and CRP in the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the levels of IL-6, IL-8 and CRP in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Pregabalin combined with Mecobalamin has a significant effect on the treatment of herpes zoster, which can effectively reduce the degree of neuropathic pain and improve the inflammatory response of patients, and the medication is safer.
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