Effect of Sacubatril Valsartan Sodium Tablets combined with Spironolactone on oxidative stress and vascular endothelial function in patients with chronic heart failure
ZHENG Wen ZHANG Yuan-ya LI Dong-fang LIAO Ling LIU Fan
Department of General Medicine, Shangrao People′s Hospital, Jiangxi Province, Shangrao 334000, China
Abstract：Objective To investigate the effect of Sacubatril Valsartan Sodium Tablets combined with Spironolactone on chronic heart failure (CHF).Methods A total of 80 CHF patients who were treated in Shangrao People′s Hospital from April 2017 to November 2019 were selected as the research objects and divided into the control group and the observation group according to random number table method, with 40 cases in each group.The control group was treated with Spironolactone, and the observation group was treated with Sacubatril Valsartan Sodium Tablets combined with Spironolactone.The clinical effect, cardiac function, oxidative stress, vascular endothelial function and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).There were no significant differences in the levels of superoxide dismutase (SOD), propylene glycol (MDA), left ventricular ejection fraction(LVEF), resistin, endothelin-1 (ET-1) and calcitonin gene-related peptide (CGRP) between the two groups before treatment (P＞0.05).After treatment, SOD, LVEF and CGRP levels in the two groups were higher than those before treatment,and observation group was higher than control group,the differences were statistically significant(P＜0.05).After treatment,the levels of resistin,ET-1 and MDA in the two groups were lower than those before treatment,and the observation group was lower than the control group, the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The treatment of CHF patients with Sacubitril Valsartan Sodium Tablets combined with Spironolactone has relatively good efficacy, which can effectively improve cardiac function, vascular endothelial function and oxidative stress and with certain safety.
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