慢性心力衰竭患者血清氨基末端脑钠肽前体和心肌肌钙蛋白I联合检测的临床意义

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摘要目的探讨慢性心力衰竭患者血清氨基末端脑钠肽前体（NT-proBNP）和心肌肌钙蛋白I（cTnI）联合检测的临床意义。方法选取2018年3～12月我院收治的49 例慢性心力衰竭患者作为观察组，选择同期我院的49 例健康体检者作为对照组，进行回顾性分析。采用纽约心脏病协会（NYHA）心功能分级方法，将观察组进一步分为：NYHA Ⅱ级观察组（17 例）、NYHA Ⅲ级观察组（16 例）、NYHA Ⅳ级观察组（16 例）。观察组患者与对照组患者均接受胶乳增强免疫比浊法、对抗体夹心免疫法检测。比较两组患者的cTnI、NT-proBNP 浓度；比较NYHA Ⅱ、Ⅲ、Ⅳ级观察组患者的cTnI、NT-proBNP 浓度；比较cTnI、NT-proBNP 浓度联合检测与单一检测在观察组患者中的真阳性率差异。结果观察组患者的cTnI 与NT-proBNP 均高于对照组，差异有统计学意义（P＜0.05）；NYHA Ⅱ级观察组患者的cTnI、NT-proBNP 浓度均低于NYHA Ⅲ、Ⅳ级观察组，差异有统计学意义（P＜0.05）；NYHA Ⅳ级观察组患者的cTnI、NT-proBNP 浓度高于NYHA Ⅲ级观察组，差异有统计学意义（P＜0.05）；观察组患者cTnI+NT-proBNP 联合检测的真阳性率，高于cTnI、NT-proBNP 单一检测，差异有统计学意义（P＜0.05）。观察组患者cTnI 单一检测的真阳性率低于NT-proBNP 单一检测，差异有统计学意义（P＜0.05）。结论血清NT-proBNP 和cTnI 联合检测的方法，可有效提高慢性心力衰竭患者的检出率，值得推广使用。

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关键词 ：慢性心力衰竭, 联合检测, 心肌肌钙蛋白I, 血清氨基末端脑钠肽前体

Abstract：Objective To investigate the clinical significance of combined detection of serum aminoterminal brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) in patients with chronic heart failure. Methods Fortynine patients with chronic heart failure admitted to our hospital from March to December 2018 were selected as the observation group, and 49 healthy patients in our hospital during the same period were selected as the control group for retrospective analysis. The New York Heart Association (NYHA) cardiac function classification method was used to further divide the observation group into：NYHA Ⅱobservation group(17 cases),NYHA Ⅲobservation group(16 cases),NYHA Ⅳobservation group (16 cases). Both the observation group and the control group received latex-enhanced immunoturbidimetry and antibody sandwich immunoassay. The concentrations of cTnI and NT-proBNP were compared between the two groups. The concentrations of cTnI and NT-proBNP were compared in the NYHA Ⅱ, Ⅲ, and Ⅳobservation groups. The true positive rate of cTnI, NT-proBNP concentration combined detection and single detection in the observation group was compared. Results The cTnI and NT-proBNP in the observation group were higher than those in the control group, the differences were statistically significant (P ＜0.05). The cTnI and NT-proBNP concentrations in the NYHA Ⅱobservation group were lower than those in the NYHA Ⅲand Ⅳobservation group, the differences were statistically significant (P＜0.05). The concentration of cTnI and NT-proBNP in NYHA Ⅳobservation group were higher than those in NYHA Ⅲobservation group, the differences were statistically significant (P＜0.05). The true positive rate of cTnI+NT-proBNP combined detection was higher than that of cTnI and NT-proBNP single detection, and the differences were statistically significant (P＜0.05). In the observation group, the true positive rate of cTnI single detection was lower than that of NT-proBNP single detection, and the difference was statistically significant(P＜0.05). Conclusion The combined detection of serum NT-proBNP and cTnI can effectively improve the detection rate of patients with chronic heart failure, which is worthy of popularization.

Key words： Chronic heart failure Combined detection Cardiac troponin I Serum amino terminal brain natriuretic peptide precursor

引用本文:

刘颁. 慢性心力衰竭患者血清氨基末端脑钠肽前体和心肌肌钙蛋白I联合检测的临床意义[J]. 中国当代医药, 2020, 27(7): 51-54.
LIU Ban. Clinical significance of combined detection of serum amino terminal brain natriuretic peptide precursor and cardiac troponin I in patients with chronic heart failure. 中国当代医药, 2020, 27(7): 51-54.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I7/51

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