Abstract：]Objective To investigate the effect of Loratadine combined with Methylprednisolone in the treatment of children with henoch schonlein purpura.Methods A total of 50 children with henoch schonlein purpura treated in General Hospital of Pingxiang Mining Group Co.,Ltd.,Jiangxi Province from March 2018 to February 2020 were selected and divided into control group (25 cases) and observation group (25 cases) according to random number table method.The control group was treated with Loratadine,and the observation group was treated with Methylprednisolone.The efficacy,serum levels of inflammatory factors,improvement time of clinical symptoms and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05).C-reactive protein and IgA in observation group were lower than those before intervention and those in control group,the differences were statistically significant (P<0.05).The levels of complement C3 and C4 in the observation group were lower than those before intervention and in the control group,the differences were statistically significant (P<0.05).The improvement time of clinical symptoms in the observation group was shorter than that in the control group,the differences were statistically significant (P<0.05).No obvious adverse reactions occurred in both groups.Conclusion For children with henoch schonlein purpura,Loratadine combined with Methylprednisolone pulse therapy can improve the clinical efficacy of children,shorten the improvement time of clinical symptoms,improve the level of serum inflammatory factors,and does not increase adverse reactions,which has high application value.
朱橙；罗新福. 氯雷他定联合甲基强的松龙冲击治疗小儿过敏性紫癜的效果[J]. 中国当代医药, 2021, 28(4): 130-132转136.
ZHU Cheng； LUO Xin-fu. Effect of Loratadine combined with Methylprednisolone in the treatment of children with henoch chonlein purpura. 中国当代医药, 2021, 28(4): 130-132转136.
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