摘要目的 比较甲巯咪唑与丙硫氧嘧啶治疗甲状腺功能亢进症（简称甲亢）的临床应用效果。方法 选取2018年1月～2019年6月我院收治的114 例甲亢患者作为研究对象，采用随机数字表法将其分为常态组（57 例）和科研组（57 例）。常态组患者采用丙硫氧嘧啶治疗，科研组患者采用甲巯咪唑治疗。比较两组患者不同时间阶段（治疗前及治疗60、90 d 后）的甲状腺激素指标水平、用药后的不良反应总发生率、治疗时间、住院时间及症状改善时间等指标。结果 科研组患者治疗60、90 d 后的游离三碘甲状腺素（FT3）、游离甲状腺素（FT4）水平低于常态组，差异有统计学意义（P＜0.05）；科研组患者治疗60、90 d 后的促甲状腺素（TSH）水平高于常态组，差异有统计学意义（P＜0.05）。科研组患者的不良反应总发生率低于常态组，差异有统计学意义（P＜0.05）。两组患者的治疗时间比较，差异无统计学意义（P＞0.05）。科研组患者的住院时间及症状改善时间短于常态组，差异有统计学意义（P＜0.05）。结论 对甲巯咪唑与丙硫氧嘧啶治疗甲亢疾病的临床效果与安全性进行比较，发现甲巯咪唑药物的安全性较高，可明显降低患者的不良反应发生率。但在实际治疗过程中，仍应当结合患者的病情选取不同的药物，并对其血常规、肝功能变化进行仔细观察。
Abstract：Objective To compare the clinical application effect of Methimazole and Propylthiouracil in the treatment of thyroid glands syndrome (hereinafter referred to as hyperthyroidism).Methods A total of 114 patients with hyperthyroidism admitted to our hospital from January 2018 to June 2019 were selected as the study subjects.The patients were divided into normal group (57 cases) and scientific research group (57 cases) by random number table method.The patients in normal group were treated with Propylthiouracil.The patients in the scientific research group were treated with Methimazole.The thyroid hormone levels at different time stages (before treatment, 60 and 90 days after treatment), the total incidence of adverse reactions, the treatment time, the length of stay and the time of symptom improvement were compared between the two groups.Results After 60 and 90 days of treatment, the levels of free triiodothyronine (FT3)and free thyroxine (FT4) in the scientific research group were lower than those in the normal group, with statistically significant differences (P＜0.05).The levels of thyroid-stimulating hormone (TSH) in the scientific research group after 60 and 90 days of treatment were higher than those in the normal group, and the differences were statistically significant (P＜0.05).The overall incidence of adverse reactions in the scientific research group was lower than that in the normal group, and the difference between the two groups was statistically significant (P＜0.05).There was no significant difference in treatment time between the two groups (P＞0.05).The length of stay and symptom improvement time of patients in the scientific research group were shorter than those in the normal group, and the differences were statistically significant (P＜0.05).Conclusion After comparing the clinical effect and safety of Methimazole with that of Propylthiouracil in the treatment of hyperthyroidism, the safety of Methimazole is higher and the incidence of adverse reactions can be reduced obviously.But in the actual treatment process should still be combined with the patient′s condition to choose different drugs, its blood routine, liver function changes for careful observation.
王明. 甲巯咪唑与丙硫氧嘧啶治疗甲状腺功能亢进症的临床效果比较[J]. 中国当代医药, 2020, 27(13): 141-144.
WANG Ming. Clinical effect comparison of Methimazole and Propylthiouracil in the treatment of thyroid glands syndrome. 中国当代医药, 2020, 27(13): 141-144.
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