Abstract：Objective To explore the influence of intrauterine infection on the curative effect of respiratory distress syndrome in premature infants. Methods A total of 56 premature infants with respiratory distress syndrome hospitalized in our hospital from November 2015 to October 2018 were selected. All the infants needed antibiotic treatment. According to the diagnosis of intrauterine infection, 50 infants with intrauterine infection were selected as group A, and 6 infants without intrauterine infection were selected as group B. The curative effect was observed. Results Before treatment,there was no significant difference in the blood gas indexes such as pH value, partial pressure of carbon dioxide (Pa-CO2) and partial pressure of blood oxygen (PaO2) between the two groups (P＞0.05). After 12 hours of treatment, the blood gas indexes such as pH value, PaCO2 and PaO2 were improved, the pH value and PaO2 of group B were higher than those of group A, and the level of PaCO2 of group B was lower than that of group A, the difference was statistically significant (P＜0.05). The time of oxygen inhalation, ventilation, hospitalization and antibiotic use in group B were shorter than those in group A, and the difference was statistically significant (P＜0.05). The incidence of complications and the use rate of PS in group B were significantly lower than those in group A, with significant difference (P＜0.05). Conclusion Intrauterine infection has many adverse effects on the curative effect of respiratory distress syndrome in premature infants. It can prolong the treatment time, increase the incidence of complications and inhibit the improvement of blood gas and oxygenation function. Therefore, it is necessary to actively prevent and treat intrauterine infection in order to effectively improve the clinical efficacy of children.
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