早期微量喂养对早产儿肠道乳酸杆菌、双歧杆菌数量及喂养不耐受发生情况的影响

摘要
图/表
参考文献(15)
相关文章 (15)

全文: PDF (0 KB) HTML (35 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨早期微量喂养对早产儿肠道乳酸杆菌、双歧杆菌数量及喂养不耐受发生情况的影响。方法选取2016年8月1日～2018年2月1日我院收治的410例早产儿作为研究对象，按照随机信封法将其分为观察组（205例）与对照组（205例）。对照组早产儿采用常规方案进行干预，观察组早产儿采用早期微量喂养方案干预。比较两组早产儿的恢复出生体重时间、拔胃管时间、达全肠内营养时间、住院时间、乳酸杆菌和双歧杆菌水平及喂养不耐受发生情况。结果观察组早产儿的恢复出生体重时间、拔胃管时间、达全肠内营养时间及住院时间均显著短于对照组，差异有统计学意义（P＜0.05）。两组早产儿治疗后3 d的乳酸杆菌及双歧杆菌水平比较，差异无统计学意义（P＞0.05）；两组早产儿治疗后7、14 d的乳酸杆菌及双歧杆菌水平均显著高于治疗后3 d，差异有统计学意义（P＜0.05）；观察组早产儿治疗后7、14 d的乳酸杆菌及双歧杆菌水平均明显高于对照组，差异有统计学意义（P＜0.05）。观察组早产儿的喂养不耐受总发生率为19.02%，显著低于对照组的66.34%，差异有统计学意义（P＜0.05）。结论采用早期微量喂养对早产儿干预后，可有效改善患儿肠道乳酸杆菌和双歧杆菌数量，并降低喂养不耐受的发生率。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	江焘
	李玉琴
	黄文武
	李海燕

关键词 ：早期微量喂养, 早产儿, 肠道乳酸杆菌, 双歧杆菌, 喂养不耐受

Abstract：Objective To investigate the effect of early micro-feeding on the number of Intestinal Lactobacilli and Bifidobacteria and the incidence of feeding intolerance in premature infants.Methods A total of 410 premature infants admitted to our hospital from August 1,2016 to February 1,2018 were selected as the study subjects.According to the random envelope method,they were divided into the observation group(205 cases)and the control group(205 cases).In the control group,routine protocols as the intervention were used,while in the observation group,early micro-feeding protocols as the intervention were adopted.The time to recover birth weight,time of gastric tube removal,time of total enteral nutrition,hospitalization time,the levels of Intestinal Lactobacilli and Bifidobacteria,and incidence of feeding intolerance were compared between the two groups.Results The time to recover birth weight,time of gastric tube removal,time of total enteral nutrition,and hospitalization time of the premature infants in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in the levels of Intestinal Lactobacilli and Bifidobacteria between the two groups 3 days after treatment(P＞0.05).The levels of Intestinal Lactobacilli and Bifidobacteria at 7 and 14 days after treatment in the two groups were significantly higher than those at 3 days after treatment,and the differences were statistically significant(P＜0.05).The levels of Intestinal Lactobacilli and Bifidobacteria at 7 and 14 days after treatment in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence rate of feeding in-tolerance in the observation group was 19.02%,which was significantly lower than that in the control group (66.34%),and the difference was statistically significant(P＜0.05).Conclusion Early micro-feeding can effectively improve the number of Intestinal Lactobacilli and Bifidobacteria and reduce the incidence rate of feeding intolerance after intervention in premature infants.

Key words： Early micro-feeding Premature infants Intestinal Lactobacilli Bifidobacteria Feeding intolerance

基金资助:广东省惠州市科技计划项目（2018Y308）

作者简介: 江焘（1984-），男，广东韶关人，本科，主治医师，研究方向：儿科消化

引用本文:

江焘;李玉琴;黄文武;李海燕. 早期微量喂养对早产儿肠道乳酸杆菌、双歧杆菌数量及喂养不耐受发生情况的影响[J]. 中国当代医药, 2019, 26(5): 101-104.
JIANG Tao;LI Yu-qin;HUANG Wen-wu;LI Hai-yan. Effect of early micro-feeding on the number of Intestinal Lactobacilli and Bifidobacteria and the incidence of feeding intolerance in premature infants. 中国当代医药, 2019, 26(5): 101-104.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2019/V26/I5/101

[3]	毛爽，罗莎.孕妇妊娠期肝内胆汁淤积症危险因素的病例对照研究[J].解放军预防医学杂志，2017，35（4）：371-373.
[5]	吕红艳，杨李红，马岩，等.益生菌联合早期微量喂养对早产儿营养及肠道菌群的影响[J].中国妇幼保健，2017，32（22）：5608-5610.
[7]	马喜华，胡蓉.早期持续微量配方奶喂养在极低体质量早产儿肠道营养中的应用研究[J].医学临床研究，2017，34（7）：1369-1371.
[1]	Bottacini F，Morrissey R，Roberts RJ，et al.Comparative genome and methylome analysis reveals restriction/modification system diversity in the gut commensal Bifidobacterium breve[J].Nucleic Acids Res，2018，2017（4）：1-18.
[2]	Gandhi A，Shah N P.Effect of salt stress on morphology and membrane composition of Lactobacillus acidophilus，Lactobacillus casei，and Bifidobacterium bifidum，and their adhesion to human intestinal epithelial-like Caco-2 cells[J].J Dairy Sci，2016，99（4）：2594-2605.
[4]	Bian X，Wang TT，Xu M，et al.Effect of Lactobacillus strains on intestinal microflora and mucosa immunity in Escherichia coli O157：H7-induced diarrhea in mice[J].Curr Microbiol，2016，73（1）：65-70.
[6]	Hamet MF，Medrano M，Pérez PF，et al.Oral administration of kefiran exerts a bifidogenic effect on BALB/c mice intestinal microbiota[J].Benef Microbes，2016，7（2）：1-10.
[8]	Martín-Peláez S，Mosele JI，Pizarro N，et al.Effect of virgin olive oil and thyme phenolic compounds on blood lipid profile：implications of human gut microbiota[J].Eur J Nutr，2017，56（1）：119-131.
[9]	Schoster A，Guardabassi L，Staempfli H R，et al.The longitudinal effect of a multi-strain probiotic on the intestinal bacterial microbiota of neonatal foals[J].Equine Vet J，2016，48（6）：689-696.
[10]	白雪，王娟，范文娟.早期间歇持续微量喂养在早产低出生体质量儿中的应用[J].实用临床医药杂志，2017，21（18）：97-99.
[11]	Xu J，Chen X，Yu S，et al.Effects of early intervention with sodium butyrate on gut microbiota and the expression of inflammatorycytokinesinneonatalpiglets[J].PLoSOne，2016，11（9）：e0162461.
[12]	吕红艳，杨李红，任朋顺，等.喂养不耐受对极低出生体重儿肠道菌群的影响[J].中国医药导刊，2017，19（8）：757-760.
[13]	Sharma BC，Singh J.Probiotics in management of hepatic encephalopathy[J].Metab Brain Dis，2016，31（6）：1295-1301.
[14]	Lyte M，Chapel A，Lyte JM，et al.Resistant starch alters the microbiota-gut brain axis：implications for dietary modulation of behavior[J].PLoS One，2016，11（1）：e0146 406.
[15]	Matias R，Emanuel F，Abeijón-Mukdsi MC，et al.Lactobacillus fermentum CRL1446 ameliorates oxidative and metabolic parameters by increasing intestinal feruloyl esterase activity and modulating microbiota in caloric-restricted mice[J].Nutrients，2016，8（7）：415.